X-ray biomedical imaging beamline at SSRF

Xie, Honglan; Deng, Bangming; Du, Guohao; Fu, Yanan; He, Yeping; Guo, Han; Peng, Guang; Xue, Ye; Zhou, Gongfu; Ren, Yifei; Wang, Y.; Chen, R.; Tong, Yali; Xiao, Tiqiao

doi:10.1088/1748-0221/8/08/c08003

Cited by 26 publications

(10 citation statements)

References 18 publications

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“…The PCCT scans were performed at BL13W1 beamline of the Shanghai Synchrotron Radiation Facility (SSRF), Shanghai, China. A schematic of the experimental setup is shown in Figure .…”

Section: Methodsmentioning

confidence: 99%

High‐resolution 3D imaging of microvascular architecture in human glioma tissues using X‐ray phase‐contrast computed tomography as a potential adjunct to histopathology

Zhang

Jian

Sun

et al. 2020

Int J Imaging Syst Tech

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Gliomas are rich in blood vessels, and the generation of tumor-associated vessels plays an important role in glioma growth and transfer. Histology can directly depict microvascular architecture in the tumor, but it just provides two-dimensional (2D) images obtained by destroying three-dimensional (3D) tissue specimens. There is a lack of high-resolution 3D imaging methods for observing the microvasculature throughout the entire specimens. X-ray phase-contrast computed tomography (PCCT) which is an emerging imaging method has demonstrated its outstanding potential in imaging soft tissues.Thus, this study aims to evaluate the potential of PCCT as an adjunct to histopathology in nondestructive and 3D visualization of the microvascular architecture in human glioma tissues. In this study, seven resected glioma tissues were scanned via PCCT and then processed histologically. The obtained PCCT data was analyzed and compared with corresponding histological results. Significant anatomical structures of the glioma such as microvessels, thrombi inside the microvessels, and areas of vascular proliferation could be clearly presented via PCCT, confirmed by the histological findings. Moreover, PCCT data also provided additional 3D information such as morphological alterations of the microvasculature, 3D distribution of the thrombi and stenosis severity of the vessels in glioma tissues, which cannot be fully analyzed in 2D histological slices. In conclusion, this study demonstrated that PCCT can offer excellent images at a near-histological level and additional valuable information in screening gliomas, without impeding further histological investigations.Thus, this technique could be potentially used as an adjunct to conventional histopathology in 3D nondestructive characterization of glioma vasculature. K E Y W O R D S glioma, microthrombi, microvascular architecture, X-ray phase-contrast computed tomography Wenxue Zhang and Jianbo Jian contributed equally to this study.

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“…The PCCT scans were performed at BL13W1 beamline of the Shanghai Synchrotron Radiation Facility (SSRF), Shanghai, China. A schematic of the experimental setup is shown in Figure .…”

Section: Methodsmentioning

confidence: 99%

High‐resolution 3D imaging of microvascular architecture in human glioma tissues using X‐ray phase‐contrast computed tomography as a potential adjunct to histopathology

Zhang

Jian

Sun

et al. 2020

Int J Imaging Syst Tech

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“…The experiment was performed on X-ray imaging and biomedical application beamline (BL13W1) at Shanghai Synchrotron Radiation Facility (SSRF) [19,20]. The schematic diagram of the in-line phase contrast microscopy system is shown in Figure 1.…”

Section: Methodsmentioning

confidence: 99%

Noninvasive 3D Structural Analysis of Arthropod by Synchrotron X‐Ray Phase Contrast Tomography

Yao

Zong

Fan

et al. 2015

Journal of Nanomaterials

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X-ray imaging techniques significantly advanced our understanding of materials and biology, among which phase contrast X-ray microscopy has obvious advantages in imaging biological specimens which have low contrast by conventional absorption contrast microscopy. In this paper, three-dimensional microstructure of arthropod with high contrast has been demonstrated by synchrotron X-ray in-line phase contrast tomography. The external morphology and internal structures of an earthworm were analyzed based upon tomographic reconstructions with and without phase retrieval. We also identified and characterized various fine structural details such as the musculature system, the digestive system, the nervous system, and the circulatory system. This work exhibited the high efficiency, high precision, and wide potential applications of synchrotron X-ray phase contrast tomography in nondestructive investigation of low-density materials and biology.

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“…where dC dh represents the Cu concentration gradient at the solder/Cu 6 Sn 5 interface in the direction vertically from Cu substrate to the solder surface, as shown in Fig. 21 Therefore, the net Cu flux from Cu substrate to the liquid solder bulk can be expressed as:…”

Section: Imc Grain Size Size and Thicknessmentioning

confidence: 99%

“…A very slow cooling rate is applied by conducting furnace cooling after reflow experiment. Considering the utmost significance of non-destructive experiments [21], especially for cooling experiment, in-situ visualizations results are provided by performing synchrotron radiation imaging experiments on air cooling and furnace cooling procedures, for a Sn/Cu interface, with solder height around or less than 100 µm.…”

Section: Introductionmentioning

confidence: 99%

Growth behavior of preferentially scalloped intermetallic compounds at extremely thin peripheral Sn/Cu interface

Shang

Kunwar

Wang

et al. 2019

J Mater Sci: Mater Electron

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The growth behaviour of Cu 6 Sn 5 intermetallic compound (IMC) at the solder height controlled post-spread Sn/Cu interface is investigated for different initial solder ball volumes, reflow temperatures and cooling rates. Because of the limited solder thickness at the periphery, the IMC retains a preferential scalloped morphology, even after cooling. For solder balls of initial diameters of 500, 1000 and 1700 µm, with the maximum solder height at the peripheral regime not exceeding 150 µm, reflowed at 250 ℃ and undergoing air cooling, it has been revealed that IMC characterized with larger layer thickness and grain diameter, correspond to the sample of smaller ball size. The increase in reflow temperature for a solder of initial size of 500 µm, is characterized by the increase in IMC thickness, developments of few but quite large faceted planes over the original scalloped morphology and non-uniformity in the grain diameter. In contrary the to air cooling (cooling rate 4.0 K/s), the IMCs obtained at the thin film zone, for furnace cooling (cooling rate = 0.037 K/s), are very larger, both in grain size and layer thickness. Moreover, the scalloped Cu 6 Sn 5 surface in furnace cooled specimens, bear many but tiny

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X-ray biomedical imaging beamline at SSRF

Cited by 26 publications

References 18 publications

High‐resolution 3D imaging of microvascular architecture in human glioma tissues using X‐ray phase‐contrast computed tomography as a potential adjunct to histopathology

High‐resolution 3D imaging of microvascular architecture in human glioma tissues using X‐ray phase‐contrast computed tomography as a potential adjunct to histopathology

Noninvasive 3D Structural Analysis of Arthropod by Synchrotron X‐Ray Phase Contrast Tomography

Growth behavior of preferentially scalloped intermetallic compounds at extremely thin peripheral Sn/Cu interface

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