The storage of supercritical CO2 in deep saline aquifers is essential for reducing carbon emissions, and selecting an appropriate reservoir is a primary task for carbon sequestration. To investigate the impact of reservoir physical properties on the CO2 storage capacity of saline aquifers, this study establishes a numerical simulation model of CO2 storage in deep saline aquifers anuses the MRST toolbox to solve it by the finite volume method. This research analyzes in detail the influence of reservoir physical properties on the CO2 migration process and CO2 storage capacity of the saline aquifers layer. The results show that CO2 injection for a long time is a process of first suppressing the pressure and then slowly diffusing it to the surroundings. Furthermore, the physical properties of the reservoir and the reservoir pressure significantly influence CO2 burial in deep saline aquifers. Higher reservoir permeability and deeper burial depth lead to more excellent CO2 storage and faster CO2 plume migration. However, the porosity and temperature of the reservoir have little impact on CO2 storage. Our research work provides a precise understanding of the selection of suitable layers for CO2 storage in deep saline aquifers, which offers strong support for early predictions of carbon capture, utilization, and storage (CCUS).