X-ray diffraction structure of a ternary copper(II) peptide complex (benzimidazole) (glycylglycinato) copper(II) trihydrate

Complexes of N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid with group 12 metals and vanadium—Synthesis, structure and bioactivity of the vanadium complex

“…The concentration of PTP1B was 60 nm, with fixed substrate concentration of 2.0 mM and the concentrations of oxovanadium complex (II) ranging between 1 nM and 10 mM.3. Results and discussionNIR spectra of all complexes in the 650-150 cm −1 region were measured and assigned according to data of analogous complexes found in the literature[16,[40][41][42][43]. The Cd-N frequencies were assigned to 431 and 456 cm −1 , respectively (aliphatic N atoms), and 278 cm −1 (N from benzimidazole); the Cd-O stretching frequency to 226 cm −1 .…”

Synthesis and characterization of a dipeptide–copper(II)– 2-aminomethylbenzimidazole ternary complex

“…1. Selected bond distances and angles are given in Table III Usually the peptide is coordinated to a metal through a deprotonated amide nitrogen in ternary Cu(II) peptide complexes [11][12][13][14][15][16].…”

“…Some copper ternary complexes coordinated by chelating ligands containing imidazole groups have been described as model compounds for hemocyanin and other copper proteins [10]. An understanding of the stereochemical effect of bound ligands on ternary peptide complexes is of great importance and the study of model compounds has led to several structural studies in recent years [11][12][13][14][15][16]. However, to the best of our knowledge, only one X-ray crystallographic structure of a ternary complex peptide-Cu(II)-benzimidazole or benzimidazole derivative, [Cu(glygly)(benzimidazole)]Á3H 2 O, has been reported [12].…”

“…An understanding of the stereochemical effect of bound ligands on ternary peptide complexes is of great importance and the study of model compounds has led to several structural studies in recent years [11][12][13][14][15][16]. However, to the best of our knowledge, only one X-ray crystallographic structure of a ternary complex peptide-Cu(II)-benzimidazole or benzimidazole derivative, [Cu(glygly)(benzimidazole)]Á3H 2 O, has been reported [12]. In this work we report the synthesis, spectroscopic characterization and X-ray structure of the ternary peptide complex [Cu(glygly)(AMBZ)(H 2 O)]ClÁH 2 O (1) (glygly ¼ glycylglycine anion, AMBZ ¼ 2-aminomethylbenzimidazole).…”

Spontaneous resolution of binary copper(II) complexes with racemic dipeptides: Crystal structures of glycyl-l-α-amino-n-butyrato copper(II) monohydrate, glycyl-d-valinato copper(II) hemihydrate, and glycyl-l-valinato copper(II) hemihydrate

“…In K 2 [Cu(glygly) 2 ] AE 6H 2 O the copper atom is ligated by the amino and peptide nitrogen atoms but not by the carboxyl oxygen atoms [1]. However, in [Cu(glygly)(H 2 O)(creat)] AE 1.5H 2 O (crea:creatinine) [2], [Cu(glygly)(bzim)] AE 3H 2 O (bzim: benzimidazole) [3], [Cu(glygly)(H 2 O) 2 ] (H 2 gly-L-gly: glycylglycine) [4], [Cu(gly-L-ala)] AE H 2 O (H 2 gly-L-ala:glycyl-L-alanine) [5], [Cu(gly-L-met)] (H 2 gly-L-met:glycyl-Lmethionine) [6], and [Cu(gly-L-trypto)(H 2 O)] AE 2H 2 O (H 2 gly-L-trypto:glycyl-L-tryptophan) [7], the copper atom is ligated by the amino and peptide nitrogen atoms, and by the carboxyl oxygen atoms. It is interesting to consider the coordinating atoms of dipeptides in more detail.…”