X-Ray Diffraction Studies of Human Aortic Elastin Residues*

Weissmann, Gerald; Weissmann, S.

doi:10.1172/jci104189

Cited by 43 publications

(9 citation statements)

References 14 publications

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“…An analysis of this material revealed that, despite its fluorescence, it is comprised predominantly of calcium phosphate and calcium carbonate with residua of protein, lipid, and, more important, iron. Enriched hydroxyapatite in isolated ceroid may associate with elastin residues, as described in a much earlier study of aortas from young and older individuals using X‐ray diffraction (25). The implications of such an association in plaque stability require further investigation.…”

Section: Discussionmentioning

confidence: 85%

Cytocidal effects of atheromatous plaque components: the death zone revisited

Östblom

et al. 2006

FASEB j.

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Section: Discussionmentioning

confidence: 85%

Cytocidal effects of atheromatous plaque components: the death zone revisited

Östblom

et al. 2006

FASEB j.

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“…Another ageassociated change that has been studied is the calcification of elastic tissue. The concentration of hydroxyapatite crystals within the elastic fibres in arteries has been shown to increase with age (Weissman & Weissman, 1960). However, there is little sign of calcification in the elastic fibres in normal lungs at any age.…”

mentioning

confidence: 99%

Chemical compositions of elastins isolated from aortas and pulmonary tissues of humans of different ages

John¹,

Thomas²

1972

Biochemical Journal

137

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1. Elastins were isolated from the visceral pleuras and parenchymas of lungs of humans of different ages. 2. The elastin content of pleuras increased whereas that of parenchymas remained constant with increasing age. 3. The amino acid compositions and carbohydrate contents of elastins isolated from both pulmonary tissues changed in the same way with increasing age of the subjects. These changes were similar to those observed in elastins isolated from the aorta. 4. Similar glycoproteins were isolated from pleuras and aortas, and were more difficult to extract from the elastins of older subjects. Contamination with these glycoproteins was responsible for the changes in composition of elastin, as the age of the tissue from which it was extracted increased. 5. The amount of the cross-linking amino acids desmosine and isodesmosine was lower in elastins isolated from both aorta and pulmonary tissues of senile subjects than those from younger subjects.

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“…Zwar lassen sich Befunde von Art zu Art nicht kritiklos ubertragen (VASTESAEGER, 1968), doch wurde beobachtet, dafl es sich im Initialstadium um ein blofles Intima-Udem handelt (HOFMANN, 1971;JORGENSEN et al, 1972), und zellige Proliferationen (LEE et al, 1970DAOUD et al, 1970), Cholesterin-und Lipideinlagerungen sowie Verkalkungen erst spater erfolgen (GIERTSEN, 1964;DAHME, 1968;WEISSMAN and WEISSMAN, 1960;MEYER u. STELZIG, 1967).…”

Section: Moglicherweise Durch Die Elektrobetaubung Oder Den Transportunclassified

Statistik, Erblichkeit und korrelative Bindung einiger Merkmale des Kreislaufsystems bei weiblichen Mastschweinen der Deutschen Landrasse*

Wegner

Feder

Reetz

2010

Zentralblatt Für Veterinärmedizin Reihe A

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Zusammenfassung An 1007 weiblichen Mastschweinen der Deutschen Landrasse im mittleren Gewicht von 100 kg, identisch gehaltene und gefütterte Nachkommengruppen aus einer Mastprüfungsanstalt, wurden folgende Merkmale des Kreislauf‐systems ermittelt: Im Schlachtblut Hämoglobingehalt, Hämatokrit, Ceruloplasminaktivität, Plasma‐Hämoglobin, ‐Cholesterin, ‐Cu, ‐Fe, ‐K, ‐Ca, ‐Mg und ‐Cl, sowie Fe, Zn, Na, K und Mg in den Erythrozyten; an den frischen Herzen und großen Gefäßen: absolutes und relatives Herzgewicht, Gewicht der Vorkammern, des linken und rechten Ventrikels und der Ventrikelquotient, Durchmesser und Umfang der Aorta und A. pulmonalis, Stärke der Intima und Media, Elastin‐ und Aschegehalt der Aorta sowie die Ascheinhaltsstoffe Cu, Fe, Ca, Na, Zn, K, Mg und P. Alle Mittelwerte der Blutdaten bewegten sich in den aus der Literatur bekannten Bereichen, wie sie von Blut aus der Venenpunktion berichtet werden. Dennoch erfolgte eine Hämolyse‐Korrektur anhand der Plasma‐Hämoglobinwerte, obwohl krasse Hämolyseeffekte nur auf den Plasma‐Eisengehalt bestanden. Der Hämolysegrad zeigte eine negative Bindung an den Elastingehalt der Aorta und einen Gipfel im Frühjahr. Die geringen Stallendgewichtsschwankungen beeinflußten die Kreislaufmerkmale nur wenig. Mit steigendem Alter nahmen besonders Hämatokrit und Cp‐Aktivität im Plasma zu, der Elastingehalt der Aorta aber ab. Hochsignifikante jahreszeitliche Effekte waren bei fast allen untersuchten Merkmalen zu verzeichnen, insbesondere beim Plasma‐Cholesterin, mit einem Tiefpunkt im Sommer und einem Höhepunkt im Winter, bei den Gefäßintimastärken, mit einem Gipfel im Frühjahr und einem Tief im Winter, sowie bei den analog reagierenden Kupfer‐ und Eisengehalten der Aorta. Die vergleichend‐medizinische Bedeutung dieser Befunde wird diskutiert. Summary Statistics, heredity and correlation between some features of the circulatory system in female German Landrace pigs I. Means and environmental effects Using 1007 female fattening pigs of the German Landrace breed, of 100 kg. mean weight, maintained and fed identically and forming progeny groups in a pig testing station, the following circulatory system parameters were studied: Hb content of slaughter blood, haematocrit, ceruloplasmin activity, plasma levels of Hb, cholesterol, Cu, Fe, K, Ca, Mg and Cl, as well as the Fe, Zn, Na, K and Mg content of erythrocytes; for the fresh heart and large vessels measurements of absolute and relative heart weight, atrial weights and left and right ventricles and ventricular quotient, diameter and circumference of the aorta and pulmonary artery, thickness of intima and media, elastin and ash content of the aorta and the amount in the ash of Cu, Fe, Ca, Na, Zn, K, Mg, and P. All the parameters gave measurements in conformity with those recorded for blood samples taken from veins. A correction for haemolysis was required for the plasma Hb value although gross effects of haemolysis were seen only with the plasma Fe content. The degree of haemolysis showed a negative correlation with the elastin conte...

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X-Ray Diffraction Studies of Human Aortic Elastin Residues*

Cited by 43 publications

References 14 publications

Cytocidal effects of atheromatous plaque components: the death zone revisited

Cytocidal effects of atheromatous plaque components: the death zone revisited

Chemical compositions of elastins isolated from aortas and pulmonary tissues of humans of different ages

Statistik, Erblichkeit und korrelative Bindung einiger Merkmale des Kreislaufsystems bei weiblichen Mastschweinen der Deutschen Landrasse*

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