X -ray measurement of the diameters of the living eye

Deller, J. F. P.; O'Connor, A. D.; Sorsby, Arnold

doi:10.1098/rspb.1947.0025

Cited by 34 publications

(1 citation statement)

References 2 publications

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“…Device size is practically constrained to a length of ≤10 mm and a cross-sectional geometry that minimizes tissue damage during insertion. Furthermore, given an ocular diameter of approximately 20 mm, 37,38 an implant in excess of 10 mm is likely to cross the central visual axis and inhibit vision. Hence a maximum device size of 8-10 mm was selected as a starting point for device design and tolerability.…”

Section: Devices Were Implanted Onmentioning

confidence: 99%

Device design methodology and formulation of a protein therapeutic for sustained release intraocular delivery

Schlesinger

Bernards

Chen

et al. 2018

Bioengineering & Transla Med

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Despite years of effort, sustained delivery of protein therapeutics remains an unmet need due to three primary challenges – dose, duration, and stability. The work presented here provides a design methodology for polycaprolactone reservoir‐based thin film devices suitable for long‐acting protein delivery to the back of the eye. First, the challenge of formulating highly concentrated protein in a device reservoir was addressed by improving stability with solubility‐reducing excipients. Next, predictive correlations between design parameters and device performance were developed to provide a methodology to achieve a target product profile. Prototype devices were designed using this methodology to achieve desired device size, release rate, therapeutic payload, and protein stability, assessed by in vitro studies. Finally, prototype tolerability was established in a non‐human primate model. The design methodology presented here is widely applicable to reservoir‐based sustained delivery devices for proteins and provides a general device design framework.

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Section: Devices Were Implanted Onmentioning

confidence: 99%