X-ray observations of tungsten wire array<i>Z</i>-pinch implosions on QiangGuang-1 facility

Zhang, Faqiang; Li, Zhenghong; Zhang, Xu; Xu, Rongkun; Yang, Jiankun; Guo, Chen; Guang-Xin, Xia; Chen, Jinchuan; Fengjun, Song; Jiamin, Ning; Wang, Zhen; Xue, Feibiao; Li, Linbo; Qin, Yi; Ying, Chun; Liu, Guangjun

doi:10.1088/1009-1963/15/9/028

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Hydatid cyst treatment is primarily done by surgery unless there is a reason. In such cases, medications are used, such as benzimidazole, albendazole, and meben- dazole (8,21). Drug treatment can only be effective for small, inactive cysts, while large and active cysts inevitably fall into surgical treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Today, leakage of cysts or leaks of their fillings during surgery is the most critical upset for surgeons (7,8). The use of scolicidal agents, e.g., hypertonic salt 20% and silver nitrate (Ag-nitrate), has been considered for reducing the risk of protoscoleces spread and relapse of the disease (9), but some complications (fibrosis of biliary ducts and liver cirrhosis) have been reported with these agents (10).…”

Section: Introductionmentioning

confidence: 99%

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Antiparasitic Effects and Cellular Mechanisms of Formononetin (a Natural Isoflavone) Against Hydatid Cyst Protoscoleces

Haghighi

Khalaf

Mahmoudvand

et al. 2023

Jundishapur J Nat Pharm Prod

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Background: The chemical agents applied to reduce the complications of hydatid cyst surgery are not free of side effects. Formononetin (FMN), as a natural isoflavone, has been shown to have various therapeutic benefits. Objectives: We studied the in vitro and ex vivo protoscolicidal activity and cellular mechanisms of FMN against hydatid cyst protoscoleces. Methods: Formononetin at 75, 150, and 300 μg/mL was mixed with hydatid cyst protoscoleces (103/mL), and the viability was determined in 5 to 60 min through eosin staining assay. The effect of FMN on caspase-3 activity was tested through a commercial colorimetric protease kit. In addition, the penetrability of the plasma membrane of protoscoleces after exposure to FMN was also determined by the SYTOX assay. Results: Formononetin at 300 μg/mL completely destroyed hydatid cyst protoscoleces after 30 minutes. While at 150 μg/mL, after 60 minutes of contact, 100% of protoscoleces were eliminated. By ex vivo assay, FMN showed its antiparasitic effect for longer periods. Based on these results, FMN at 300 μg/mL concentration completely eliminated hydatid cyst protoscoleces after 60 minutes of exposure. While at a concentration of 150 μg/mL after 60 minutes, 89.6% of protoscoleces were destroyed. Formononetin noticeably increased (P < 0.001) the activity of caspase-3 and the permeability of protoscoleces dose-dependently. Conclusions: Formononetin as a natural product showed promising effects on the protoscoleces of hydatid cysts, indicating that it can be considered a valuable scolicidal agent. However, additional investigations are necessary to evaluate its efficacy in animal models and human subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antiparasitic Effects and Cellular Mechanisms of Formononetin (a Natural Isoflavone) Against Hydatid Cyst Protoscoleces

Haghighi

Khalaf

Mahmoudvand

et al. 2023

Jundishapur J Nat Pharm Prod

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Experimental investigation of Z-pinch radiation source for indirect drive inertial confinement fusion

Wang

et al. 2019

Matter and Radiation at Extremes

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Z-pinch dynamic hohlraums (ZPDHs) could potentially be used to drive inertial confinement fusion targets. Double- or multishell capsules using the technique of volume ignition could exploit the advantages of ZPDHs while tolerating their radiation asymmetry, which would be unacceptable for a central ignition target. In this paper, we review research on Z-pinch implosions and ZPDHs for indirect drive targets at the Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics. The characteristics of double-shell targets and the associated technical requirements are analyzed through a one-dimensional computer code developed from MULTI-IFE. Some key issues regarding the establishment of suitable sources for dynamic hohlraums are introduced, such as soft X-ray power optimization, novel methods for plasma profile modulation, and the use of thin-shell liner implosions to inhibit the generation of prior-stagnated plasma. Finally, shock propagation and radiation characteristics in a ZPDH are presented and discussed, together with some plans for future work.

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X-ray observations of tungsten wire arrayZ-pinch implosions on QiangGuang-1 facility

Cited by 2 publications

References 18 publications

Antiparasitic Effects and Cellular Mechanisms of Formononetin (a Natural Isoflavone) Against Hydatid Cyst Protoscoleces

Antiparasitic Effects and Cellular Mechanisms of Formononetin (a Natural Isoflavone) Against Hydatid Cyst Protoscoleces

Experimental investigation of Z-pinch radiation source for indirect drive inertial confinement fusion

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