X-ray phase imaging: from synchrotron to hospital

Momose, Atsushi; Yashiro, Wataru; Kido, Kazuhiro; Kiyohara, Junko; Makifuchi, Chiho; Ito, Tsukasa; Nagatsuka, Sumiya; Honda, Chika; Noda, Daiji; Hattori, Tadashi; Endo, Tokiko; Nagashima, Masato; Tanaka, Junji

doi:10.1098/rsta.2013.0023

Cited by 89 publications

(65 citation statements)

References 13 publications

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“…Application of SAXS and WAXS in vivo is also very difficult due to the high X-ray dose required for signal detection, because the primary X-ray beam is blocked and the signal is only generated from the scattered X-ray photons, which are several orders of magnitude less than the transmitted ones. However, X-ray phase-contrast methods based on gratingbased dark-field imaging [164,288] could be more easily adopted to be used in vivo in animals [221,289] and eventually in humans [290,291], whereas they can also be combined with standard X-ray absorption methods [223,292]. Their use in providing information on ultrastructure organization [161,169], by exploiting ultrastructure orientation-dependent signal modulations [168,293], is expected to rise in the future, as these methods have not been adequately explored to date [169].…”

Section: In Vivo Assessmentmentioning

confidence: 99%

Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils

Georgiadis

Müller

Schneider

2016

J. R. Soc. Interface.

113

100

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Bone's remarkable mechanical properties are a result of its hierarchical structure. The mineralized collagen fibrils, made up of collagen fibrils and crystal platelets, are bone's building blocks at an ultrastructural level. The organization of bone's ultrastructure with respect to the orientation and arrangement of mineralized collagen fibrils has been the matter of numerous studies based on a variety of imaging techniques in the past decades. These techniques either exploit physical principles, such as polarization, diffraction or scattering to examine bone ultrastructure orientation and arrangement, or directly image the fibrils at the sub-micrometre scale. They make use of diverse probes such as visible light, X-rays and electrons at different scales, from centimetres down to nanometres. They allow imaging of bone sections or surfaces in two dimensions or investigating bone tissue truly in three dimensions, in vivo or ex vivo, and sometimes in combination with in situ mechanical experiments. The purpose of this review is to summarize and discuss this broad range of imaging techniques and the different modalities of their use, in order to discuss their advantages and limitations for the assessment of bone ultrastructure organization with respect to the orientation and arrangement of mineralized collagen fibrils.

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Section: In Vivo Assessmentmentioning

confidence: 99%

Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils

Georgiadis

Müller

Schneider

2016

J. R. Soc. Interface.

113

100

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“…(The reverse scenario is also possible.) Although research is underway, phase-contrast CT technology currently is limited to very small imaging fields of view, does not operate at clinical CT energies (up to 140 keV), and requires additional acquisitions to obtain the requisite data, which may increase dose and/or extend the data collection time [79, 81]. …”

Section: Ct Technologymentioning

confidence: 99%

Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral CT technologies

Yeh

Fitzgerald

Edic

et al. 2017

Advanced Drug Delivery Reviews

165

144

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The introduction of spectral CT imaging in the form of fast clinical dual-energy CT enabled contrast material to be differentiated from other radiodense materials, improved lesion detection in contrast-enhanced scans, and changed the way that existing iodine and barium contrast materials are used in clinical practice. More profoundly, spectral CT can differentiate between individual contrast materials that have different reporter elements such that high-resolution CT imaging of multiple contrast agents can be obtained in a single pass of the CT scanner. These spectral CT capabilities would be even more impactful with the development of contrast materials designed to complement the existing clinical iodine- and barium-based agents. New biocompatible high-atomic number contrast materials with different biodistribution and X-ray attenuation properties than existing agents will expand the diagnostic power of spectral CT imaging without penalties in radiation dose or scan time.

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“…It has demonstrated superior contrast and visibility compared to conventional absorption xray imaging and has shown potential in many applications from biomedicine to materials science. 4 Among different XPCI methods, [5][6][7][8][9][10][11][12] we focus on the edge illumination (EI) technique, 13 which could extend the capability of extracting phase information to common laboratory x-ray sources. 14 This extension, sometimes referred to as coded-aperture (CA) XPCI, has a non-interferometric nature with a simple setup.…”

Section: Introductionmentioning

confidence: 99%

Edge-illumination x-ray phase contrast imaging with Pt-based metallic glass masks

Saghamanesh

Aghamiri

Olivo

et al. 2017

Review of Scientific Instruments

Self Cite

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Edge-illumination x-ray phase contrast imaging (EI XPCI) is a non-interferometric phase-sensitive method where two absorption masks are employed. These masks are fabricated through a photolithography process followed by electroplating which is challenging in terms of yield as well as time-and cost-effectiveness. We report on the first implementation of EI XPCI with Pt-based metallic glass masks fabricated by an imprinting method. The new tested alloy exhibits good characteristics including high workability beside high x-ray attenuation. The fabrication process is easy and cheap, and can produce large-size masks for high x-ray energies within minutes. Imaging experiments show a good quality phase image, which confirms the potential of these masks to make the EI XPCI technique widely available and affordable. Published by AIP Publishing. [http://dx

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X-ray phase imaging: from synchrotron to hospital

Cited by 89 publications

References 13 publications

Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils

Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils

Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral CT technologies

Edge-illumination x-ray phase contrast imaging with Pt-based metallic glass masks

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