X‐ray Radiation‐Controlled NO‐Release for On‐Demand Depth‐Independent Hypoxic Radiosensitization

Fan, Wenpei; Bu, Wenbo; Zhang, Zhen; Shen, Bo; Zhang, Hui; He, Qianjun; Ni, Dalong; Cui, Zhaowen; Zhao, Kuaile; Bu, Jiwen; Du, Jiulin; Liu, Jianan; Shi, Jianlin

doi:10.1002/anie.201504536

Cited by 261 publications

(151 citation statements)

References 37 publications

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“…Thus, our group further developed nano-droplets of PFC stabilized by albumin as an oxygen shuttle for tumor-specific delivery of oxygen with the help of tumor-focused low-intensity ultrasound (Figure 13). 2017, 29,1700996 Hemoglobin-based oxygen carrier [230,237] Perfluorocarbon (PFC) emulsions; BSA coated PFC emulsion; PFC loaded hollow Bi 2 Se 3 ; TaOx decorated with PFC nanodroplets [238][239][240][241] Mild hyperthermia [39,71,73] Increase tumor oxygenation by catalysis of endogenic H 2 O 2 MnO 2 nanopartilces; MnO 2 nanosheets@ upconversion; Au@MnO 2 core-shell [242][243][244][245][246][247] Polymer micelles encapsulating catalase and TaOx@catalase [248][249][250] Hypoxia-specific therapy accompany hypoxia-specific cytotoxicity of tirapazamine [58,251] X-ray controlled NO releasing [56] Radioprotection to reduce side effects Free radical scavengers CeO 2 nanoparticles [252,253] Melanin nanoparticles [254,255] MoS 2 dots [256] Oxygen-loaded nanoparticles were able to enhance tumor oxygenation triggered by the NIR laser. injected into tumorbearing mice under hyperoxic breathing.…”

Section: Increase Of Tumor Oxygenation By Oxygen Deliverymentioning

confidence: 99%

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

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Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However, owing to the low radiation absorption of tumors, high doses of ionizing radiations are often needed during RT, leading to severe damages to normal tissues adjacent to tumors. Meanwhile, the RT efficacies are limited by different mechanisms, among which the tumor hypoxia-associated radiation resistance is a well-known one, as there exists hypoxia inside most solid tumors while oxygen is essential to enhance radiation-induced DNA damages. With the development in nanotechnology, there have been great interests in using nanomedicine strategies to enhance radiation responses of tumors. Nanomaterials containing high-Z elements to absorb radiation rays (e.g. X-ray) can act as radio-sensitizers to deposit radiation energy within tumors and promote treatment efficacy. Nanoscale carriers are able to deliver therapeutic radioisotopes into tumors for internal RIT, or chemotherapeutic drugs for synergistically combined chemo-radiotherapy. As uncovered in recent studies, the tumor microenvironment could be modulated by various nanomedicine approaches to overcome hypoxia-associated radiation resistance. Herein, the authors will summarize the applications of nanomedicine for RT cancer treatment, and pay particular attention to the latest development of 'advanced materials' for enhanced cancer RT.

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Section: Increase Of Tumor Oxygenation By Oxygen Deliverymentioning

confidence: 99%

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

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“…[2] Especially in the field of cancer therapy, NO not only directly kills cancerous cells at high concentrations (> 1 mm) through the nitrosation of mitochondria and DNA, [3] but also cooperatively enhances the efficacy of photodynamic therapy or radiotherapy. [4] Of particular interest of NO gas therapy is to…”

Section: Asanalternativetochemotherapytheemerginggastherapymentioning

confidence: 99%

Glucose‐Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving‐Like/Gas Therapy

et al. 2016

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Glucose is a key energy supplier and nutrient for tumor growth. Herein, inspired by the glucose oxidase (GOx)-assisted conversion of glucose into gluconic acid and toxic H O , a novel treatment paradigm of starving-like therapy is developed for significant tumor-killing effects, more effective than conventional starving therapy by only cutting off the energy supply. Furthermore, the generated acidic H O can oxidize l-Arginine (l-Arg) into NO for enhanced gas therapy. By using hollow mesoporous organosilica nanoparticle (HMON) as a biocompatible/biodegradable nanocarrier for the co-delivery of GOx and l-Arg, a novel glucose-responsive nanomedicine (l-Arg-HMON-GOx) has been for the first time constructed for synergistic cancer starving-like/gas therapy without the need of external excitation, which yields a remarkable H O -NO cooperative anticancer effect with minimal adverse effect.

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“…However, the use of X-ray irradiation as an external stimulus to trigger drug release in chemoradiation therapy is rarely studied. [12] It is conceivable that integrating ROS responsive materials may provide a mechanistic way of X-ray triggered drug release, yet this strategy needs careful consideration on the limited lifetime and short diffusion distance of ROS generated upon irradiation. [13] …”

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confidence: 99%

Synchronous Chemoradiation Nanovesicles by X‐Ray Triggered Cascade of Drug Release

et al. 2018

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The approach of concurrent-to-synchronous chemoradiation has now been advanced by well-designed nanovesicles that permit X-ray irradiation-triggered instant drug release. The nanovesicles consist of Au nanoparticles tethered with irradiation labile linoleic acid hydroperoxide (LAHP) molecules and oxidation-responsive poly(propylene sulfide)-poly(ethylene glycol) (PPS-PEG) polymers, where DOX were loaded in the inner core of the vesicles (Au-LAHP-vDOX). Upon irradiation, the in situ formation of hydroxyl radicals from LAHP molecules triggers the internal oxidation of PPS from being hydrophobic to hydrophilic, leading to degradation of the vesicles and burst release of cargo drugs. In this manner, synchronous chemoradiation showed impressive anticancer efficacy both in vitro and in a subcutaneous mouse tumor model by one-dose injection and one-time irradiation.

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X‐ray Radiation‐Controlled NO‐Release for On‐Demand Depth‐Independent Hypoxic Radiosensitization

Cited by 261 publications

References 37 publications

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Glucose‐Responsive Sequential Generation of Hydrogen Peroxide and Nitric Oxide for Synergistic Cancer Starving‐Like/Gas Therapy

Synchronous Chemoradiation Nanovesicles by X‐Ray Triggered Cascade of Drug Release

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