2001
DOI: 10.1021/la0009285
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X-ray Scattering Studies of Maquette Peptide Monolayers. 2. Interferometry at the Vapor/Solid Interface

Abstract: We apply X-ray interferometry to study the profile structure of Langmuir-Blodgett (LB) monolayers containing maquette peptides, de novo di-R-helical synthetic peptides designed as model systems for studying biological electron transfer. The results demonstrate that it is possible to create monolayers with the peptide vectorially oriented with its helical axis (the direction of electron transfer within the holopeptide) approximately normal to the surface of the solid support. This orientation can even be achiev… Show more

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Cited by 10 publications
(8 citation statements)
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“…BBC16 monolayers were already characterized by chemical [12] and x-ray reflectivity methods [7,13], making them good systems for further structural investigation by neutron reflectivity. Key aspects of the peptide design and x-ray reflectivity results are summarized in Figs.…”
Section: Resultsmentioning
confidence: 99%
“…BBC16 monolayers were already characterized by chemical [12] and x-ray reflectivity methods [7,13], making them good systems for further structural investigation by neutron reflectivity. Key aspects of the peptide design and x-ray reflectivity results are summarized in Figs.…”
Section: Resultsmentioning
confidence: 99%
“…In studies of a monolayer plus protein system ( Fig. 2), other authors have described the protein as an additional slab of uniform electron density (8,29,(36)(37)(38)(39)(40). However, a protein like PKCa-C2 has a robust structure with a well-defined arrangement of atoms and, therefore, a specific electron density profile for a given orientation.…”
Section: Discussionmentioning
confidence: 99%
“…Previously, the dihelices of a representative 4-helix bundle, whose sequence was designated “BB”, were made amphiphilic via attachment of C16 hydrocarbon chains to their N-termini This vectorial orientation could be maintained upon the Langmuir−Blodgett deposition of these monolayers onto the nonpolar soft alkylated surface of a solid inorganic substrate . Furthermore, electron transfer was demonstrated between the peptide's prosthetic group(s) and the solid substrate …”
Section: Introductionmentioning
confidence: 99%
“…[8][9][10] This vectorial orientation could be maintained upon the Langmuir-Blodgett deposition of these monolayers onto the nonpolar soft alkylated surface of a solid inorganic substrate. 11 Furthermore, electron transfer was demonstrated between the peptide's prosthetic group(s) and the solid substrate. 12 However, the amphiphilic BBC16 had certain limitations.…”
Section: Introductionmentioning
confidence: 99%