X-ray Structure of (NH4)6(Gly-Gly)2V10O28.cntdot.4H2O: Model Studies for Polyoxometalate-Protein Interactions

Crans, Debbie C.; Mahroof-Tahir, Mohammad; Anderson, Oren P.; Miller, Matthew J.

doi:10.1021/ic00102a036

Cited by 141 publications

(82 citation statements)

References 2 publications

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“…[8] Recently, hybrid materials, [9] organic decavanadates, have been synthesized with the aim to understand their biological, [10] magnetic, [11] and optical properties. [12] Organic ligands such as tetra-Nalkylammonium, [13,14] tetra-N-butylammonium, [15,16] imidazole, [17] 1,2,4-triazole, [17] 1,10-phenanthroline, [18] cytosine, [19] the dipeptide glycylglycine, [20] and biguanide derivatives have been employed. [8] The organic ligands allow the vicinity of the latter, as a result of the strong Coulombic forces that arise from the ionic charges.…”

Section: Introductionmentioning

confidence: 99%

“…Although 2 and 3 crystallize in the same centrosymmetric space group as 1, a remarkable difference for 2 and 3 is that the [V 10 O 28 ] 6-anion is placed on an inversion center, which is not the case for 1. modulation of the structures and properties of the new hybrid materials on the basis of electrostatic and hydrogenbond interactions. [9] Interestingly, inorganic and organic decavanadates have been used as building blocks [21] to generate supramolecular frameworks that exhibit wide structural diversity in one, two, or three dimensions (e.g., chains, [13,20,22] layers, [14,16,23] channels, [24] or 3D networks). [10,14,17,18] The formation of the supramolecular structure is strongly dependent on the solvent, [25] pH value, ionic strength, temperature, and nature of the counterions [13][14][15][16][17][18][19][20][21]26] used in the synthesis.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of Metforminium(2+) Decavanadates – Crystal Structures and Solid‐State Characterization

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis of Metforminium(2+) Decavanadates – Crystal Structures and Solid‐State Characterization

et al. 2014

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“…The use of a single compound containing vanadium and small amine organic molecule is required from a pharmaceutical point of view. The preparation of these types of salts have been previously reported [3][4][5][6]. Our group is interested in preparing arylalkylamine decavanadate(V) salts and to test them as insulinomimetic agents.…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of hexakis(4-fluorophenylethylammonium)decavanadate( V) tetrahydrate, (C8H11FN)6[V10O28] · 4H2O

Yraola¹,

Alberício²,

Royo³

et al. 2008

Zeitschrift Für Kristallographie - New Crystal Structures

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Source of materialSodium vanadate (1.120 g, 10 mol) was dissolved in water (30 ml) and pH was adjusted at 7.4 by addition of 1NHCl. Then 4-fluorophenylethylammonium (1.053 g, 6mol) hydrochloride was added, which induced the precipitation of a solid. This solid was filtered under vacuum and dried over P2O5 in a vacuum oven at 30°C to obtain the title compound. Afterwards, a saturated solution of the title compound in water or H2O was prepared, and evaporated at room temperature to obtain orange needles. V NMR data are available in the CIF. Experimental details21 H atoms were located from a difference synthesis and refined with overall isotropic temperature factors and 16 H atoms were not found, from which 14 were computed and refined using a riding model, with isotropic displacement parameters equal to 1.2 times the equivalent temperature factors of the atoms which are linked. The two Hatoms attached to water O15 were not analyzed. DiscussionA combination formed by vanadium compounds and amines of the semicarbazide-sensitive amine oxidase (SSAO) substrate group has been described [1,2] to show a potent synergic insulin effect. The use of a single compound containing vanadium and small amine organic molecule is required from a pharmaceutical point of view. The preparation of these types of salts have been previously reported [3][4][5][6]. Our group is interested in preparing arylalkylamine decavanadate(V) salts and to test them as insulinomimetic agents. As example, the salt hexaquabis(benzylammonium) decavanadate(V) dihydrate (C7NH10)6[V10O28] · 2H2O was recently synthesized and characterized chemically and biologically [7]. The crystal structure of the title compound reveals the presence of two water molecules, three (4-fluorophenyl)ethylammonium cations (C 8 H 11 FN) + and one half of the decavanadate anion V10O28 6-in the asymmetric unit ( figure, top). The bond angles and distances for the V10O28 6-unit shows that the geometry is quite similar to that of decavanadate salts reported in other studies. In the V10O28 6-, each VO6 octahedron is considerably dis-Z. Kristallogr.

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“…These compounds are interesting precursors for hybrid organic-inorganic materials which could provide a variety of interesting properties such as anti-viral, antineoplastic, catalytic and anti-carcinogenic properties [13][14][15][16][17][18][19]. Amino acids are the basic units ____________________ of many biological molecules and their incorporation into large polyatomic structures may illuminate key interactions of great importance in bioinorganic chemistry [19][20][21]. In the frame of this strategy, our group is primarily concerned with biological activities of these hybrids [5,6], we were interested in the synthesis of a new derivative with potentially promising biological activity.…”

Section: Introductionmentioning

confidence: 99%

“…It is found that the polyoxoanions may act as a molecular acceptor which attracts nitrogen and oxygen atoms of the organic donor, L-proline, in this novel molecular assembly [20,21].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of tetraprolinium silicotungstic acid tetra‐hydrate, a new organic‐inorganic hybrid based on polyoxometallates

Alizadeh¹,

Tayebee

Mirzaei

2008

Cryst. Res. Technol.

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A new solvated polyoxometallate bearing an amino acid, (I), has been prepared for the first time by the reaction of 0.16 mmol α-H 4 SiW 12 O 40 .15H 2 O with 0.78 mmol of L-proline in hydrochloric acid at pH 3. The structure of (I) was substantially characterized by some physical approaches, such as elemental analysis, infrared spectroscopy, and 1 H-NMR. Our findings proved that (I) could be formulated as [L-It is believed that the electrostatic attractions and hydrogen bonding between tungstosilisic acid and the prolinium cation affected the structure of (I). It is evident that the polyoxometallates moieties were arranged in good order to form large holes in the structural backbone. These cavities were occupied by the prolinium cations and water molecules.

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X-ray Structure of (NH4)6(Gly-Gly)2V10O28.cntdot.4H2O: Model Studies for Polyoxometalate-Protein Interactions

Cited by 141 publications

References 2 publications

Synthesis of Metforminium(2+) Decavanadates – Crystal Structures and Solid‐State Characterization

Synthesis of Metforminium(2+) Decavanadates – Crystal Structures and Solid‐State Characterization

Crystal structure of hexakis(4-fluorophenylethylammonium)decavanadate( V) tetrahydrate, (C8H11FN)6[V10O28] · 4H2O

Synthesis and characterization of tetraprolinium silicotungstic acid tetra‐hydrate, a new organic‐inorganic hybrid based on polyoxometallates

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