XAGE-1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma

Pan, Ze‐Ya; Tang, Bo; Hou, Zhenyu; Zhang, Jin; Liu, Hui; Yang, Yuan; Huang, Gang; Yang, Yun; Zhou, Weiping

doi:10.3892/mco.2014.336

Cited by 8 publications

(9 citation statements)

References 20 publications

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“…The current study found that XAGE1-positive ovarian cancer patients had considerably greater levels of XAGE1 gene expression than benign tumor patients, indicating that the XAGE1 gene has a high specificity as a diagnostic marker for distinguishing malignant from benign ovarian cancer. Our findings were consistent with a recent study that found elevation of XAGE 1b mRNA expression in 64.4 percent of hepatocellular carcinoma tissue samples, but not in any benign liver tumors [ 21 ]. Gjerstorff et al discovered significant levels of expression of numerous cancer-testis antigens (CTAs) in Tumorigenicity human mesenchymal stem cells, including XAGE-1 [ 22 ].…”

Section: Discussionsupporting

confidence: 94%

“…The statistically significant difference in expression levels in connection to stage III has been shown compared with stage I. Similar results were found in earlier research, including Pan et al , who reported that XAGE 1b mRNA levels were raised in patients with hepatocellular carcinoma with higher stages of tumor node metastasis [II~IV][ 21 ]. Men et al have discovered the pulmonary metastatic capacity of XAGE-1b in nude mice [ 28 ], but no association between CT expression and clinical variables like tumor history and histology has been observed in lung cancer patients [ 26 ].…”

Section: Discussionsupporting

confidence: 86%

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Cancer testis antigen XAGE-1 is a promising marker for the diagnosis and treatment of ovarian cancer

https://orcid.org¹,

https://orcid.org²

2021

JMedLife

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Cancer testis antigens have been discovered in various cancers, and several studies have suggested that since they exhibit such distinct patterns of expression, these antigens might be attractive targets for cancer detection and immunotherapy. Our work attempted to clarify the function played by cancer-testis antigens in ovarian cancers, notably in the XAGE1 gene. The investigation was conducted on 74 tissue samples from newly diagnosed patients with ovarian cancer. The control group included twenty-eight benign ovarian tumors. The expression of XAGE1 mRNA was assessed using RT-PCR. Compared to benign tumors, cancer samples exhibited higher levels of XAGE1 gene expression, which was statistically significant (P0.01). There were no statistically significant differences between menopausal status and family history. Gene expression was substantially connected with age groups as the higher level of gene expression in patients 50–74 years of age (P 0.01) was seen. Mucinous tumors exhibited significant correlations (P0.01) across histopathological tumor types. In correlation with tumor stages, stage III was substantially linked compared to stage I (P0.01). In conclusion, we referred to the potential to use XAGE1 to discriminate malignant ovarian tumors as a diagnostic biomarker. The connection of high XAGE 1 level with advanced ovarian cancer stages has also been established, supporting XAGE 1’s proposed role in poor prognosis. Finally, finding the specific involvement of this gene in ovarian cancer and other kinds of malignancies may require further investigations.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 86%

Cancer testis antigen XAGE-1 is a promising marker for the diagnosis and treatment of ovarian cancer

https://orcid.org¹,

https://orcid.org²

2021

JMedLife

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“…The expression of the CTA family XAGE-1b is significantly higher in liver cancer tissues and peripheral blood than in a non-liver cancer group. Because the expression level of XAGE-1b is closely associated with the 1-year recurrence rate of patients 27 , it can be useful for early diagnosis and prognosis. The expression levels of the CTA family members MAGE-3 and MAGE-4 mRNA are significantly higher in the peripheral blood of metastatic hepatocellular carcinoma patients than in a non-metastasis group, and they can be used to determine whether hepatoma cells undergo blood vessel metastasis 28 .…”

Section: Discussionmentioning

confidence: 99%

Overexpression of TMEFF1 in Endometrial Carcinoma and the Mechanism Underlying its Promotion of Malignant Behavior in Cancer Cells

et al. 2021

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Background: Although tomoregulin-1 (TMEFF1) is involved in embryonic development and central nervous system regulation and is a cancer suppressor gene in brain cancers, its role in endometrial carcinoma remains unclear. Methods: The expression and prognostic value of TMEFF1 were analyzed by bioinformatics methods and immunohistochemistry. An endometrial carcinoma cell line with low expression of TMEFF1 was constructed. Scratch and Transwell assays were used to determine the effect of TMEFF1 on cell invasion and migration. Changes in key proteins in the MAPK and PI3K/AKT signaling pathways and in epithelial-mesenchymal transition (EMT)-related proteins were analyzed using western blot. Chromatin immunoprecipitation assay (ChIP) was performed to identify whether the TMEFF1 promoter region binds to the transcription factor p53. Results: TMEFF1 was significantly upregulated in endometrial carcinoma, was closely associated with FIGO stage ( P =0.021) and lymph node metastasis ( P =0.029), and was an independent risk factor for prognosis ( P =0.044). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses showed that TMEFF1 and its related genes are involved in the cell cycle, regulation of mitosis, epigenetics, neural development, cell biological signal transduction and some key signal pathways. We also identified kinases, microRNAs and a transcription factor network related to TMEFF1 and the effect of TMEFF1 mutation on prognosis. In vitro knockdown of TMEFF1 significantly inhibited cell invasion and migration. Knockdown of TMEFF1 inhibited Epithelial-mesenchymal transition (EMT) and activation of the MAPK and PI3K/AKT pathways. However, the transcription factor p53 was not found to regulate the TMEFF1 gene. Conclusion: TMEFF1 plays an important role in endometrial carcinoma and may thus be a potential anticancer therapeutic target for endometrial carcinoma.

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“…XAGE-1b is considered as a tumor serological marker which assisted clinical diagnosis [7,14] . Moreover, signi cant dysregulated levels of XAGE-1b were observed in several tumors [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]21] . However, XAGE-1b expression in GC and its role in the prognosis of GC patients remain unclear.…”

Section: Discussionmentioning

confidence: 99%

“…XAGE-1b is characterized as wide expression spectrum, high expression rate and strong immunogenicity, which also leads to a variety of transcription variations. It has been reported that XAGE-1b was highly expressed in melanoma [5,6] , lung cancer [7][8][9][10][11][12][13] , prostate cancer [14,15] and hepatocellular carcinoma [16,17] , and was correlated with the tumor poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

XAGE-1b Promotes the Proliferation, Invasion and Metastasis of Gastric Cancer

Zhang

Tan

et al. 2020

Preprint

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Background X antigen family member 1B (XAGE-1b), a member of XAGE subfamily and GAGE family, is upregulated in some malignant tumors and has been associated with the proliferation, invasion and metastasis of tumors. However, the biological roles of XAGE-1b in gastric cancer (GC) still remain unclear. Methods We detected the expression of XAGE-1b in 60 paired fresh tissues of GC patients by real-time RT-PCR. Kaplan-Meier survival curve was explored to analyze 5-year survival time of GC patients. Function experiments were performed to estimate the role of XAGE-1b on the proliferation, invasion and metastasis of GC cells. Informatic analysis was applied to investigate the potential mechanisms. Results XAGE-1b was obviously upregulated in GC tissues. XAGE-1b was correlated significantly with poor prognosis of GC patients. XAGE-1b markedly promoted the proliferation and invasion in GC cell lines in vitro. Knockdown of XAGE-1b promoted the pulmonary metastatic ability in nude mice. Moreover, XAGE-1b was positively or negatively correlated with the expression of CLDN6 and CHGA, which regulated the progression of GC. Conclusions XAGE-1b could act as an oncogene in GC, which provides a potential biological marker or treatment target for GC.

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XAGE-1b expression is associated with the diagnosis and early recurrence of hepatocellular carcinoma

Cited by 8 publications

References 20 publications

Cancer testis antigen XAGE-1 is a promising marker for the diagnosis and treatment of ovarian cancer

Cancer testis antigen XAGE-1 is a promising marker for the diagnosis and treatment of ovarian cancer

Overexpression of TMEFF1 in Endometrial Carcinoma and the Mechanism Underlying its Promotion of Malignant Behavior in Cancer Cells

XAGE-1b Promotes the Proliferation, Invasion and Metastasis of Gastric Cancer

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