Xanthan gum enhances humoral immune response elicited by a DNA vaccine against leptospirosis in mice

Silveira, Marcelle Moura; Vargas, Samantha; Mendonça, Marcelo; Cunha, C. E.; Hartwig, Daine; Seixas, Amilton; Bampi, Suely Ribeiro; Rodrigues, Amanda Ávila; Conceição, Fabrício Rochedo; Moreira, Ângela Nunes

doi:10.1186/1753-6561-8-s4-p153

Cited by 2 publications

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“…For example, researchers studied various P. multocida vaccines providing protective immunity against progressive atrophic rhinitis in swine [16,31,32]. Traditional vaccines have played vital roles in controlling and eradicating infectious diseases for a long time [33]. Currently, the most widely used and marketed P. multocida vaccines in China are a whole-cell formalin-killed P. multocida C44-1 bacterin emulsified with aluminum-hydroxide-gel, and a live EO630 vaccine.…”

Section: Discussionmentioning

confidence: 99%

Immune Protective Efficacy of China’s Traditional Inactivated and Attenuated Vaccines against the Prevalent Strains of Pasteurella multocida in Mice

et al. 2021

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Capsular type A and D strains of Pasteurella multocida are the main epidemic serogroups in pigs in China. In this study, we preliminarily evaluated the immune protective efficacy of the two traditional vaccines, an inactivated C44-1 aluminum-hydroxide-gel-adjuvanted (Alh–C44-1) vaccine and a live EO630 vaccine, against currently circulating strains of P. multocida in a mouse model. Mice immunized twice with conventional vaccines generated higher antibody titers, and significantly higher levels of IgG were observed in the mice inoculated with the inactivated Alh–C44-1 vaccine on day 35 (p < 0.05) than those with the live EO630 vaccine. The mice immune protection test showed that the vaccination groups had a 57% or 71% protection effect against the serogroup B strain, but had no protective effect against epidemic strains. In conclusion, our study found that the widely used traditional P. multocida vaccines in China provide good protection against homologous strains, but could not provide cross-protection against heterologous strains in a mouse model.

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