Xanthenes in Medicinal Chemistry – Synthetic strategies and biological activities

Maia, Mariana; Resende, Diana I. S. P.; Durães, Fernando; Pinto, Madalena; Sousa, Emília

doi:10.1016/j.ejmech.2020.113085

Cited by 70 publications

(28 citation statements)

References 109 publications

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“…The development of drugs involves the assessment of absorption, distribution, metabolism and excretion (ADME), parameters that must be evaluated as early as possible that process. In this context, computational models are very good approaches, to provide access to a set of rapid, yet robust predictive models, for physical-chemical, pharmacokinetic, pharmacokinetic properties and compatibility with medicinal chemistry requirements [ 58 ]. To complement the information disclosed, the pharmacokinetic parameters were evaluated in this document using the SWISSADME platform [ 59 ].…”

Section: Adme Propertiesmentioning

confidence: 99%

Small Molecules of Marine Origin as Potential Anti-Glioma Agents

et al. 2021

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Marine organisms are able to produce a plethora of small molecules with novel chemical structures and potent biological properties, being a fertile source for discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Glioma is classified by the WHO as the most common and aggressive form of tumor on CNS. Currently, Temozolomide is the only chemotherapeutic option approved by the FDA even though having some limitations. This review presents, for the first time, a comprehensive overview of marine compounds described as anti-glioma agents in the last decade. Nearly fifty compounds were compiled in this document and organized accordingly to their marine sources. Highlights on the mechanism of action and ADME properties were included. Some of these marine compounds could be promising leads for the discovery of new therapeutic alternatives for glioma treatment.

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Section: Adme Propertiesmentioning

confidence: 99%

Small Molecules of Marine Origin as Potential Anti-Glioma Agents

et al. 2021

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“…It is worth mentioning that the experiment analyzed the variables based on PCA, being this responsible for correlating those with the Kd (equilibrium) values. Source : Maia, et al, (2021).…”

Section: Xanthenementioning

confidence: 99%

Dyes and pigments used in foods: an integrative literature review

Oliveira

Silva

Alves

et al. 2021

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The food colors are, in many countries, widely used to give food increased visual sensory quality, aiming, thus, the growth of the consumer market. Aware of this, the present work aimed to reevaluate the general properties of synthetic food dyes and natural pigments, the latter being generally used to replace the former. Then, the current analysis was based on the search for the strategy, selection of articles (with inclusion and exclusion criteria), eligibility, and data extraction. Thus, it was observed in studies that synthetic food dyes may cause several harmful effects to human health, among them, genetic damage and carcinogenicity. On the other hand, the use of natural pigments as an alternative to replace food dyes has been increasingly present in studies, presenting qualities that, previously, were not known, as is the case of anthocyanins, which have important physiological and ecological functions. It is also important to point out that the use of natural pigments goes beyond the limits of food, and are also found as sensitizers for solar cells, tissues, and medicines. Selected articles (47) leaded to a total of 72 distinct pieces of information, focused mainly on the biological activities and involving natural dyes and pigments. In short, the gradual replacement of dyes, currently used, still in large scale in some locations, by natural pigments, is already part of our present, allowing the creation of a future perspective with the production of processed foods without the damage that most of synthetic dyes produce to the human body.

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“…The inhibitors reported here are a subset of the xanthen-3-ones tested, whereas other xanthen-3-ones and related compounds do not have inhibitory activity. Xanthene derivatives have been shown to have a range of medicinal properties, such as potential neuroprotective, antitumor, and antibacterial activities, among others ( Ghahsare et al., 2019 ; Maia et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%