Xanthine oxidase and lens oxidative stress markers in diabetic and senile cataract patients

Mirić, Dijana; Kisic, Bojana; Zoric, Lepsa; Mitic, Radoslav; Miric, B.; Dragojević, Ilija

doi:10.1016/j.jdiacomp.2012.09.005

Cited by 32 publications

(23 citation statements)

References 35 publications

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“…Hyperglycemia is proposed to contribute to lens oxidative damage through the enhancement of ocular and systemic XO activity (Miric et al, 2013). This study reported lens XO activity was increased in diabetic cataract patients.…”

Section: Discussionmentioning

confidence: 79%

“…High cell turnover is also prominent in the case of high serum uric acid concentrations (Higgins, 2009). Increased XO activity is reported to be associated with oxidative stress in many diseases such as cardiovascular disease, diabetes, cataracts, and metabolic syndrome (MS) (Furukawa et al, 2004;Galassetti, 2012;Feoli et al, 2014;Miric et al, 2013). However, to our knowledge, there has been no data concerning the associations between XO activity and PCOS.…”

Section: Introductionmentioning

confidence: 99%

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Is Xanthine oxidase activity in polycystic ovary syndrome associated with inflammatory and cardiovascular risk factors?

Işık

Aynıoğlu

Tımur

et al. 2016

Journal of Reproductive Immunology

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Is Xanthine oxidase activity in polycystic ovary syndrome associated with inflammatory and cardiovascular risk factors?

Işık

Aynıoğlu

Tımur

et al. 2016

Journal of Reproductive Immunology

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“…Serum XOD activity was measured according to the method of Roussos [18], as described earlier [8]. XOD activity was calculated after correction for preexisting uric acid, using molar absorbance of uric acid at λ = 293 nm, of ε = 1.26 × 10 4 L × M −1 × cm −1 .…”

Section: Methodsmentioning

confidence: 99%

“…In diabetic patients, hyperglycemia-induced endothelial dysfunction is chronic and not limited solely to the blood vessels irrigating nerve tissue but to variable extent occurs throughout the body. Moreover, XOD has been previously linked to oxidative damage in diabetes [6, 7] and diabetic cataract [8], as well as metabolic syndrome and its cardiovascular complications [9], and the role of XOD was also proposed in an experimental model of diabetic neuropathy [10]. …”

Section: Introductionmentioning

confidence: 99%

Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy

Mirić¹,

Kisić²,

Filipović-Danić³

et al. 2016

Journal of Diabetes Research

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This study investigated the relationship between serum xanthine oxidase (XOD) activity and the occurrence of diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients. Serum XOD activity, ischemia-modified albumin (IMA), uric acid (UA), albumin, glycated hemoglobin (HbA1c), advanced glycation end products (AGE), total free thiols, atherogenic index of plasma (AIP), and body mass index (BMI) were measured in 80 T2DM patients (29 with and 51 without DPN), and 30 nondiabetic control subjects. Duration of diabetes, hypertension, medication, and microalbuminuria was recorded. Serum XOD activities in controls, non-DPN, and DPN were 5.7 ± 2.4 U/L, 20.3 ± 8.6 U/L, and 27.5 ± 10.6 U/L (p < 0.01), respectively. XOD activity was directly correlated to IMA, UA, BMI, HbA1c, and AGE, while inversely correlated to serum total free thiols. A multivariable logistic regression model, which included duration of diabetes, hypertension, AIP, HbA1c, UA, and XOD activity, revealed HbA1c [OR = 1.03 (1.00–1.05); p = 0.034] and XOD activity [OR = 1.07 (1.00–1.14); p = 0.036] as independent predictors of DPN. Serum XOD activity was well correlated to several other risk factors. These results indicate the role of XOD in the development of DPN among T2DM patients.

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“…Recently, studies have demonstrated that intense inflammatory responses (Dickerson & Findly, ) and oxidative stress (Garcia et al., ) contribute directly to disease pathogenesis. However, the effects of disease on enzymes belonging to the purinergic system, through the activities of adenosine deaminase (ADA) and xanthine oxidase (XO), which are considered novel markers of the inflammatory response (Tonin et al., ) and oxidative damage (Miric et al., ), respectively, remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status

Baldissera

Souza

Doleski

et al. 2017

Journal of Fish Diseases

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Adenosine deaminase (ADA) activity, through adenosine (Ado) levels, as well as xanthine oxidase (XO) activity through uric acid levels exerts an essential role on immune and inflammatory responses during infectious diseases. Thus, the aim of this study was to evaluate the involvement of seric ADA and XO activities in the inflammatory and oxidative status of silver catfish naturally infected with Ichthyophthirius multifiliis. Seric ADA activity decreased, while Ado levels increased in infected animals compared to uninfected animals. Moreover, the seric XO activity increased in infected animals compared to uninfected animals, alongside the seric levels of uric acid, metabolites of nitric oxide (NOx) and reactive oxygen species (ROS). Based on this evidence, the downregulation of seric ADA activity exerts an anti-inflammatory profile, contributing to restricting the inflammatory process. The most important finding is that upregulation of seric XO activity leads to an excessive formation of uric acid, which contributes to oxidative and inflammatory processes. Moreover, uric acid induces the release of pro-inflammatory and pro-oxidative mediators, such NOx and ROS, which contribute directly to disease pathogenesis. In summary, the upregulation of XO activity may be considered a pathway involved in NOx and ROS production in silver catfish infected with I. multifiliis.

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Xanthine oxidase and lens oxidative stress markers in diabetic and senile cataract patients

Cited by 32 publications

References 35 publications

Is Xanthine oxidase activity in polycystic ovary syndrome associated with inflammatory and cardiovascular risk factors?

Is Xanthine oxidase activity in polycystic ovary syndrome associated with inflammatory and cardiovascular risk factors?

Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy

Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status

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