Is Xanthine oxidase activity in polycystic ovary syndrome associated with inflammatory and cardiovascular risk factors?

Işık, Hatice; Aynıoğlu, Öner; Tımur, Hakan; Şahbaz, Ahmet; Harma, Müge; Çan, Murat; Güven, Berrak; Alptekın, Husnu; Köktürk, Fürüzan

doi:10.1016/j.jri.2016.06.002

Cited by 29 publications

(16 citation statements)

References 27 publications

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“…The observed elevations in LH, LH/FSH ratio, estrogen, and testosterone among women with PCOS in the present study, together with decreased levels of progesterone and SHBG, were in agreement with previous studies . The non‐significant change in FSH levels found in the present study might be attributed to negative feedback by elevated levels of 17β‐estradiol .…”

Section: Discussionmentioning

confidence: 60%

Evaluation of biochemical, endocrine, and metabolic biomarkers for the early diagnosis of polycystic ovary syndrome among non‐obese Saudi women

Daghestani

2018

Intl J Gynecology & Obste

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Section: Discussionmentioning

confidence: 60%

Evaluation of biochemical, endocrine, and metabolic biomarkers for the early diagnosis of polycystic ovary syndrome among non‐obese Saudi women

Daghestani

2018

Intl J Gynecology & Obste

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“…Although no consensus has been reached the formation of oxidative stress, one theory is related to the increased number of mononuclear cells that develop secondarily to hyperglycaemia in PCOS patients. Increased amounts of mononuclear cells cause enhanced production of inflammatory cytokines and free oxygen radicals [25]. Molecular damage due to free oxygen radicals has been suggested to play an important role in the aetiopathogenesis of PCOS [26].…”

Section: Discussionmentioning

confidence: 99%

Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Sak

Uyanıkoğlu

Incebiyik

et al. 2018

Clin Exp Reprod Med

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ObjectiveThe aim of this study was to compare serum fetuin-A levels and oxidative stress markers, as indicators of insulin resistance, in women with polycystic ovary syndrome (PCOS) and in healthy controls.MethodsThis prospective case-control study included 46 patients with PCOS and 48 age- and body mass index–matched control women. Levels of serum hormones, fetuin-A, and oxidative stress markers were measured in blood samples taken during the early follicular period from each participant.ResultsFollicle-stimulating hormone (FSH), luteinising hormone (LH), total testosterone levels, and the LH/FSH ratio were found to be significantly higher in women with PCOS than in controls. Serum total antioxidant status, total oxidant status, and oxidative stress index parameters all indicated significantly higher levels of oxidative stress in PCOS patients than in controls. Serum fetuin-A levels, which were analyzed as an indicator of insulin resistance, were higher in the PCOS group than in the control group (210.26±65.06 µg/mL and 182.68±51.20 µg/mL, respectively; p=0.024).ConclusionThe data obtained from the present study suggest that higher levels of both serum fetuin-A and oxidative stress markers might be related with PCOS.

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“…In the present study, upregulation of seric XO activity may be interpreted as the inflammatory and pro-oxidant profiles possibly contributing to intense cellular injury, due to augmentation of uric acid and ROS levels, molecules with pro-inflammatory and pro-oxidant effects, respectively (Kang & Ha, 2014;Zhao, Vanhoutte, & Leung, 2015). Novaes et al (2015) demonstrated that upregulation Recently, Isik et al (2016) has suggested that an increase in XO activity, through excessive formation of uric acid, induces the release of pro-inflammatory and pro-oxidative mediators, such as NOx and ROS. In the present study, an increase in ROS formation observed in the serum of infected animals may be considered a host defence against I. multifiliis, but the excessive ROS directly damages the surrounding tissue or cells, promoting oxidative and inflammatory processes (Ritter et al, 2017).…”

Section: Seric Xo Activity and Uric Acid Levelsmentioning

confidence: 54%

“…Recently, Isik et al. () has suggested that an increase in XO activity, through excessive formation of uric acid, induces the release of pro‐inflammatory and pro‐oxidative mediators, such as NOx and ROS. In the present study, an increase in ROS formation observed in the serum of infected animals may be considered a host defence against I. multifiliis, but the excessive ROS directly damages the surrounding tissue or cells, promoting oxidative and inflammatory processes (Ritter et al., ).…”

Section: Discussionmentioning

confidence: 99%

Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status

Baldissera

Souza

Doleski

et al. 2017

Journal of Fish Diseases

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Adenosine deaminase (ADA) activity, through adenosine (Ado) levels, as well as xanthine oxidase (XO) activity through uric acid levels exerts an essential role on immune and inflammatory responses during infectious diseases. Thus, the aim of this study was to evaluate the involvement of seric ADA and XO activities in the inflammatory and oxidative status of silver catfish naturally infected with Ichthyophthirius multifiliis. Seric ADA activity decreased, while Ado levels increased in infected animals compared to uninfected animals. Moreover, the seric XO activity increased in infected animals compared to uninfected animals, alongside the seric levels of uric acid, metabolites of nitric oxide (NOx) and reactive oxygen species (ROS). Based on this evidence, the downregulation of seric ADA activity exerts an anti-inflammatory profile, contributing to restricting the inflammatory process. The most important finding is that upregulation of seric XO activity leads to an excessive formation of uric acid, which contributes to oxidative and inflammatory processes. Moreover, uric acid induces the release of pro-inflammatory and pro-oxidative mediators, such NOx and ROS, which contribute directly to disease pathogenesis. In summary, the upregulation of XO activity may be considered a pathway involved in NOx and ROS production in silver catfish infected with I. multifiliis.

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Is Xanthine oxidase activity in polycystic ovary syndrome associated with inflammatory and cardiovascular risk factors?

Cited by 29 publications

References 27 publications

Evaluation of biochemical, endocrine, and metabolic biomarkers for the early diagnosis of polycystic ovary syndrome among non‐obese Saudi women

Evaluation of biochemical, endocrine, and metabolic biomarkers for the early diagnosis of polycystic ovary syndrome among non‐obese Saudi women

Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status

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