Xanthine oxidase inhibitory activity of Arcangelisia flava

Abstract

Background: Uric acid is generated from xanthine and hypoxanthine through the action of xanthine oxidase. Yellow wood contains flavonoids that inhibit xanthine oxidase activity.
 Objective: This study aims to determine the effectiveness of ethanol extracts of the leaves and stems of yellow wood in inhibiting xanthine oxidase.
 Methods: The leaves and stems of yellow wood were extracted with 96% ethanol. Xanthine oxidase activity was measured using UV Vis spectrophotometry at 293 nm at various doses of extracts, and inhibition was represented as the IC50 value. Control was performed with allopurinol.
 Results: Leaves and stems of yellow wood extract inhibited xanthine oxidase by 17.56% and 96.85% at 50 ppm, with IC50 values of 174.62 and 30.85, respectively.
 Conclusion: It demonstrates that stem extracts of yellow wood are more effective than leaves at inhibiting xanthine oxidase, lowering uric acid levels.