Xanthine oxidase inhibitory activity of selected Australian native plants

Sweeney, Adam; Wyllie, S. Grant; Shalliker, R. Andrew; Markham, Julie L.

doi:10.1016/s0378-8741(01)00176-3

Cited by 124 publications

(93 citation statements)

References 12 publications

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“…The assay was conducted based on previously reported procedure (Sweeney et al, 2001) with slight modifications. The samples were tested at the concentrations of 200, 100, 50, 25, and 12.5 g/ml.…”

Section: Xanthine Oxidase Inhibitory (Xoi) Activitymentioning

confidence: 99%

Chemical characterization and antioxidant activity of three medicinal Apiaceae species

Maulidiani

Abas

Khatib

et al. 2014

Industrial Crops and Products

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a b s t r a c tCentella asiatica ('Pegaga' = Malaysia) is well known plant that has been used as one of the ingredients in pharmaceutical and cosmetic industries. Using liquid chromatography with diode array and electrospray ionization/mass spectrometry (LC-DAD-ESI/MS) analysis, chemical profiling of three different Pegaga extracts (C. asiatica, H. bonariensis and H. sibthorpioides) revealed variations in their metabolite profile. Our findings showed that triterpenes of C. asiatica were characterized by the ursane-type triterpenes (madecassoside, asiaticoside, madecassic acid, and asiatic acid), while the two Hydrocotyle species consisted of oleanane-type triterpenes (barrigenol derivatives). Other variations are due to the difference in phenolic and flavonoid constituents. The three Pegaga extracts were also evaluated for their total phenolic content (TPC), 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals, and xanthine oxidase inhibition (XOI) activities. The results showed that C. asiatica has the most potent antioxidant activity (TPC = 72.09 mg/100 g DW; DPPH = 72.99 g/ml; XOI = 87.68 g/ml) as compared to H. bonariensis (TPC = 28.55 mg/100 g DW; DPPH = 22.43 g/ml; XOI = 32.23 g/ml) and H. sibthorpioides (TPC = 56.23 mg/100 g DW; DPPH = 37.86 g/ml; XOI = 14.73. g/ml).

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Section: Xanthine Oxidase Inhibitory (Xoi) Activitymentioning

confidence: 99%

Chemical characterization and antioxidant activity of three medicinal Apiaceae species

Maulidiani

Abas

Khatib

et al. 2014

Industrial Crops and Products

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“…The xanthine oxidase inhibitory activity was quantitated as previously described (Chiang et al, 1994;Kong et al, 2001;Sweeney et al, 2001). The substrate and the enzyme solutions were prepared immediately before use.…”

Section: Xanthine Oxidase Activitymentioning

confidence: 99%

“…To find such inhibitor, botanical sources were relentlessly investigated to fish out any clinically applicable XO inhibitors (Kong et al, 2000;Sweeney et al, 2001;Zhu et al, 2004;Zhao et al, 2006;Wang et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, antihyperuricemic and xanthine oxidase inhibitory activities ofHyoscyamus reticulatus

Mohammad¹,

Almasri²,

Tawaha³

et al. 2010

Pharmaceutical Biology

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“…7 The inhibitors of XO may be used for the treatment of gout or other XO induced diseases. 8 Several works have shown that phenolic compounds and flavonoids play a role as antioxidants including: inhibition of oxidative enzymes such as XO, 9 and scavenging of free radicals. 10 Plants are a rich source of antioxidants such as phenolic compounds, anthocyanins and flavonoïds.…”

Section: Introductionmentioning

confidence: 99%

Study of the Antioxidant Property and Xanthine Oxidase Inhibitory Activity of Various Extracts from the Algerian Medicinal Plant Paronychia argentea L.

Adjadj¹,

Djarmouni²

2018

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Introduction: Paronychia argentea L. is used in traditional medicine to treat various diseases in Algeria especially kidney stones. This study was focused on the antioxidant and xanthine oxidase inhibitory activities of these plant extracts. Methods: The different extracts were prepared using solvents of increasing polarity, and their total polyphenols and flavonoids contents were determined using spectrophotomet ric methods. The antioxidant activities of Paronychia argentea extracts (PAE) were assessed by their inhibitory effect on xanthine oxidase (XO) and their scavenger ability on superoxide radical (O 2•-) generated by this enzyme. Results: The analysis PAE showed that ethyl-acetate extract (EaE) has the highest concentration of total phenolics and flavonoids compared with the chloroform extract (ChE) and the crude extract (CE). Results revealed that all PAE were effective in both XO inhibiting and superoxide radical scavenging, with the following order for the two assays: ChE > EaE > CE. Conclusion: This study provided evidence that PAE had interesting antioxidant potential which was confirmed using two enzymatic methods. Therefore, this plant could be used to treat gout and lot of diseases, where inhibition of XO and scavenging of superoxide radical are necessary.

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Xanthine oxidase inhibitory activity of selected Australian native plants

Cited by 124 publications

References 12 publications

Chemical characterization and antioxidant activity of three medicinal Apiaceae species

Chemical characterization and antioxidant activity of three medicinal Apiaceae species

Antioxidant, antihyperuricemic and xanthine oxidase inhibitory activities ofHyoscyamus reticulatus

Study of the Antioxidant Property and Xanthine Oxidase Inhibitory Activity of Various Extracts from the Algerian Medicinal Plant Paronychia argentea L.

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