Xanthogranulomas associated with hematologic malignancy in adulthood

Shoo, Brenda A.; Shinkai, Kanade; McCalmont, Timothy H.; Fox, Lindy P.

doi:10.1016/j.jaad.2008.03.046

Cited by 57 publications

(45 citation statements)

References 31 publications

(28 reference statements)

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“…In contrast, our patient's negative B symptoms, normal SPEP and lab values, and chest X‐ray do not favor an underlying malignancy. In addition to monoclonal gammopathies, other forms of hematologic abnormality or malignancy have also been reported in adults with XG, including essential thrombocytosis, large B‐cell lymphoma and adult T‐cell lymphoma/leukemia . Treatment for most cases of XG is observation, but in adults, spontaneous involution is slower, in which case, surgery may be considered .…”

Section: Discussionmentioning

confidence: 99%

“…Rarely, XG can exhibit numerous skin lesions sometimes presenting in an eruptive fashion. Eruptive XG is most commonly idiopathic, but has been reported in some cases to be a cutaneous manifestation of hematologic malignancy . The association remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

“…Eruptive XG is most commonly idiopathic, but has been reported in some cases to be a cutaneous manifestation of hematologic malignancy. 2 The association remains to be elucidated. We present a rare case of eruptive xanthogranuloma in an otherwise healthy adult man.…”

Section: Introductionmentioning

confidence: 99%

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Eruptive xanthogranuloma in a healthy adult male

2017

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Xanthogranuloma is a benign, non-Langerhans cell histiocytosis primarily diagnosed in infants and children, although a subset occurs in adults. Multifocal eruptive presentation of xanthogranuloma is very rare with only 4 previous cases reported in the literature to our knowledge. We describe a case of eruptive xanthogranuloma in a 49-year-old man who presented with sudden onset of numerous asymptomatic, red-yellow to orange papules on the face, scalp, axilla, flank and scrotum. Histologic features were consistent with xanthogranuloma with diffuse mixed infiltrate of foamy histiocytes, Touton giant cells and lymphocytes. Other than temporarily elevated non-fasting triglycerides, lab values have been unremarkable including serum plasma electrophoresis; however, the patient will continue to be monitored for ocular and other extracutaneous involvement and hematologic malignancies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Eruptive xanthogranuloma in a healthy adult male

2017

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“…[12][13][14][15][16][17][18][19][20][21][22] Eighteen patients had more than 10 lesions. [14][15][16][17][18][19][20][21][22] In four cases, MAXG occurred in an eruptive manner, 13,[15][16][17] , and three cases were associated with hematological malignancy, lymphocytic leukemia, and monoclonal gammopathy. 15,19 Association with noninsulin-dependent diabetes appears to be significant but is present only in 23% of MAXG cases.…”

Section: Discussionmentioning

confidence: 99%

A histiocytic disorder that does not easily fit into the classification of the juvenile xanthogranuloma family

et al. 2013

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“…Rare but well‐documented associated conditions of the disease include neurofibromatosis and leukemia, most commonly juvenile chronic myelogenous leukemia . Multiple lesions in adulthood may also be associated with hematologic malignancy …”

Section: Non‐langerhans Cell Histiocytosesmentioning

confidence: 99%

The clinical spectrum of xanthomatous lesions of the eyelids

et al. 2017

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Yellowish papules, nodules, or plaques, namely "xanthomatous" lesions, may be seen on the eyelids in the course of various disorders. The prototype is "xanthelasma palpebrarum" (XP) that is localized only to the eyelids and may be associated with hyperlipidemia. On the other hand, different types of normolipemic disorders may also cause xanthomatous eyelid lesions. Among these, Langerhans cell histiocytosis, diffuse normolipemic xanthoma, and non-Langerhans cell histiocytoses (papular xanthoma, juvenile xanthogranuloma, xanthoma disseminatum, adult-onset xanthogranuloma, adult-onset asthma and periocular xanthogranuloma, necrobiotic xanthogranuloma, Erdheim-Chester disease, Rosai-Dorfman disease, and reticulohistiocytosis) can be listed. The eyelid findings of this heterogeneous group of disorders are challenging to differentiate from each other due to common clinical aspects that may even sometimes mimic XP. Nodularity, induration, ulceration, diffuse eyelid involvement, and extension from eyelids to the neighboring skin may represent the clinical features of xanthomatous lesions other than XP. It is necessary to obtain a thorough history and exclude XP and then perform detailed dermatological and systemic examination, biopsy for histopathologic confirmation, and appropriate specific imaging screens. As some of the conditions may be associated with other systemic disorders, especially malignancies, the differentiation of xanthomatous eyelid lesions has a critical importance, and clinical signs can be guiding.

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Xanthogranulomas associated with hematologic malignancy in adulthood

Cited by 57 publications

References 31 publications

Eruptive xanthogranuloma in a healthy adult male

Eruptive xanthogranuloma in a healthy adult male

A histiocytic disorder that does not easily fit into the classification of the juvenile xanthogranuloma family

The clinical spectrum of xanthomatous lesions of the eyelids

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