Xanthomatous pseudotumor of lung. A case report with electron microscope and lipid studies

Wentworth, Paul; Lynch, Matthew; Fallis, J. C.; Turner, James A.; Lowden, J. A.; Conen, Patrick E.

doi:10.1002/1097-0142(196808)22:2<345::aid-cncr2820220211>3.0.co;2-0

Cited by 60 publications

(9 citation statements)

References 27 publications

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“…The prognosis of patients who undergo complete resection of endobronchial inflammatory pseudotumors is favorable; 8 however, an inflammatory pseudotumor compressing the mediastinum has been reported. 14 While these tumors may invade the mediastinum, 6,13 diaphragm, 13,15 and chest wall, 16 metastasis has never been reported. Although recurrence after surgical excision is unusual, long-term follow-up is required because recurrence as late as 9-11 years after surgery has been reported.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of a bronchial inflammatory pseudotumor by bronchoplasty in an 8-year-old boy: Report of a case

et al. 2000

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We report herein the rare case of an 8-year-old boy in whom an inflammatory pseudotumor of the upper lobe bronchus of the right lung was successfully treated by bronchoplasty. A bronchoscopy was initially performed to investigate the cause of pulmonary atelectasis in the right upper lobe, which revealed a tumor in the right main bronchus. Thus, a thoracotomy followed by bronchotomy of the right main bronchus was carried out. The tumor was seen to have polypoid protrusion into the right main bronchus at the orifice of the upper lobe. A bronchoplasty with a wedge resection of the right main bronchus and right upper lobectomy was carried out, effectively preserving right pulmonary function. Histological examination confirmed the diagnosis of an inflammatory pseudotumor. The patient had an uneventful postoperative course and has been free of recurrence for 3 years since his operation.

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Section: Discussionmentioning

confidence: 99%

Successful treatment of a bronchial inflammatory pseudotumor by bronchoplasty in an 8-year-old boy: Report of a case

et al. 2000

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“…The electron microscopical features of seven cases of pulmonary and extrapulmonary plasma cell granulomas have previously been described (Wentworth et al 1968, Kuzela 1975, Buell et al 1976.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary plasma cell granuloma—an electron microscopic and tissue culture study

Álvarez-Fernández¹,

Escalona-Zapata²

1983

Histopathology

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A case of pulmonary plasma cell granuloma studied by electron microscopy and tissue culture is reported. Ultrastructurally, it showed a polymorphic composition in which a variety of inflammatory cells, collagen fibres and capillary vessels were identified. In vitro there was an initial emigration of inflammatory cells, followed by a predominance of fibroblasts and histiocytes. This pattern of growth is similar to that obtained from explants of granulation tissue and gives support to the previously suggested view that these lesions are inflammatory pseudotumours.

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“…Wentworth and his colleagues (Wentworth Lynch, Fallis, Turner, Lowden, and Conen, 1968), described a xanthomatous pseudotumour of the lung in which they found large amounts of phospholipid and cholesterol. They considered that the composition of the lipids was quite unlike that of the xanthomata of the skin and suggested that the lipid may have originated from neuronal elements.…”

Section: Discussionmentioning

confidence: 99%

“…There may however, be examples where the lipid component is so great that the suggested epithelial origin of the lipid is obscured. This group includes the cases of Edwards and Taylor (1938), Scott, Morrow, and Payne (1948), Umiker and Iverson (1954), Titus, Harrison, Clagett, Anderson, and Knaff (1962), Sherwin, Kern, and Jones (1965), Wentworth et al (1968), Dubilier, Bryant, and Danielson (1968), Kaufman, Goldberg, and Tyagi (1968), and Long, Nutt, and MacArthur (1970). These authors make no mention of a papillary element in their cases which is such a feature of the cases of Goorwitch and Madoff (1955), Liebow and Hubbell (1956), Hill and Eggleston (1972), and the present two cases.…”

Section: Discussionmentioning

confidence: 99%

`Sclerosing haemangioma' of the lung: an alternative view of its development

Kennedy

1973

J Clin Pathol

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SYNOPSIS 'Sclerosing haemangioma' is a name which has been applied to a group of uncommon benign pulmonary lesions characterized by their papillary nature, a sclerotic stroma containing lipid, and, in some cases, evidence of haemorrhage. There is little evidence that these lesions are really angiomatous. Studies of two examples removed surgically after being discovered as incidental radiographic findings, show that the cells lining the papillae have large vacuoles which contain whorled, electron-dense inclusions. These epithelial cells have the features of granular pneumonocytes, cells known to contain phospholipid. Both lipid and cholesterol are abundant in the stroma of both tumours and the lipid is distributed in a nodular fashion. Histochemically the lipid gives a strong reaction to stains for phospholipid and it is suggested that the lipid is derived, not from the haemorrhage, but is produced by the epithelial element of the tumour.

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Xanthomatous pseudotumor of lung. A case report with electron microscope and lipid studies

Cited by 60 publications

References 27 publications

Successful treatment of a bronchial inflammatory pseudotumor by bronchoplasty in an 8-year-old boy: Report of a case

Successful treatment of a bronchial inflammatory pseudotumor by bronchoplasty in an 8-year-old boy: Report of a case

Pulmonary plasma cell granuloma—an electron microscopic and tissue culture study

`Sclerosing haemangioma' of the lung: an alternative view of its development

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