Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana

Ryu, Hyung Won; Long, Marcus J. C.; Jung, Sunin; Jin, Young Min; Cho, Jung Keun; Ryu, Young Bae; Lee, Woo Song; Park, Ki Hun

doi:10.1016/j.bmc.2010.07.033

Cited by 55 publications

(34 citation statements)

References 25 publications

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“…Swertia species have also been investigated for the presence of essential elements [105][106][107]. Xanthones have been reported to display hepatoprotective, antimicrobial, anticarcinogenic, antileprosy, antioxidant, anticholinergic, mutagenicity [108,109], and radioprotective effect [110], immunomodulatory effect [111], antibone resorption [112], and antiparasitic effects [113], neuraminidase inhibitory [114], antimalarial [115], anticomplement [116], antifungal and algicidal [117], and anti-HIV activity [118], and cardioprotective, antitumoral, antibacterial, antidiabetes, antihyperlipidemic, antiatherogenic, immunomodulator, anti-inflammatory, antiulcer, antiviral, antifungal [119], antidiabetic, hypolipidemic [120], analgesic, antiasthmatic, antihistaminic, antiamoebic, diuretic, antidiarrheal, larvicidal, ovicidal, antiprotozoal, antileptospiral, anti-TMV, and anticancer activities [121][122][123][124]. Xanthones from S. mussotii were evaluated for their anti-hepatitis B virus activity on HepG 2.2.15 cells line; they exhibited significant activity inhibiting hepatitis B virus DNA replication with IC 50 values from 0.01 mM to 0.13 mM [125].…”

Section: Biological Activities Of Xanthonesmentioning

confidence: 99%

Naturally Occurring Xanthones: Chemistry and Biology

Negi

Bisht

Singh

et al. 2013

Journal of Applied Chemistry

164

120

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Xanthones are one of the biggest classes of compounds in natural product chemistry. A number of xanthones have been isolated from natural sources of higher plants, fungi, ferns, and lichens. They have gradually risen to great importance because of their medicinal properties. This review focuses on the types, isolation, characterization, biological applications, and biosynthesis of naturally occurring xanthones isolated so far. Different physicochemical and instrumental methods such as liquid-solid and liquid-liquid extraction, TLC, flash chromatography, column chromatography, IR,1H NMR and13C NMR spectroscopy, GLC, HPLC, GC, and LCMS have been widely used for isolation and structural elucidation of xanthones. Hepatoprotective, anticarcinogenic, antileprosy, antimalarial, antioxidant, anticholinergic, mutagenicity, radioprotective, immunomodulatory, antibone resorption, antiparasitic, neuraminidase inhibitory, anticomplement, antibacterial, antifungal, algicidal, anti-HIV, cardioprotective, antitumoral, antidiabetes, antihyperlipidemic, antiatherogenic, anti-inflammatory, antiulcer, antidiabetic, hypolipidemic, analgesic, antiasthmatic, antihistaminic, antiamoebic, diuretic, antidiarrheal, larvicidal, and ovicidal activities have been reported for natural occurring xanthones. To a certain extent, this review provides necessary foundation for further research and development of new medicines.

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Section: Biological Activities Of Xanthonesmentioning

confidence: 99%

Naturally Occurring Xanthones: Chemistry and Biology

Negi

Bisht

Singh

et al. 2013

Journal of Applied Chemistry

164

120

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“…469.2590). The IR spectrum indicated the presence of carbonyl (1728 cm -1 ) and hydroxy (3433 cm -1 ) functionalities, while the UV spectrum showed absorption maxima at 243, 274, 321 and 368 nm, indicating a typical xanthone chromophore [22][23][24]. The 1 H NMR spectroscopic data (Table 1) The location of the hydrated geranyl unit at C-2 was confirmed by HMBC correlations from H-1' (δ H 2.80) to C-1 (δ C 159.1), C-2 (δ C 111.6) and C-3 (δ C 161.1), while a phenolic resonance at δ H 13.21 (OH-1) also showed HMBC correlations with C-1 (δ C 159.1), C-2 (δ C 111.6) and C-9a (δ C 103.2).…”

Section: Cochinchinone M (1) [] Dmentioning

confidence: 99%

Bioactive Xanthones from Cratoxylum cochinchinense

Raksat

Sripisut

Maneerat

2015

Natural Product Communications

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“…Some xanthone compounds were isolated from the leaves of mangosteen (Garcinia mangostana L.), which were collected in Vietnam and provided by Dr Duy Hoang Le (Kobe Pharmaceutical University). The chemical structures were determined by spectroscopic analyses and comparison with reported data (27)(28)(29)(30). The identified eight compounds are α-mangostin (1), β-mangostin (2), 3,6-di-O-methyl-γ-mangostin (3), fuscaxanthone C (4), gartanin (5), 8-deoxygartanin (6), mangostanin (7) and morusignin I (8) (Fig.…”

Section: Methodsmentioning

confidence: 99%

Screening of mammalian DNA polymerase and topoisomerase inhibitors from Garcinia mangostana L. and analysis of human cancer cell proliferation and apoptosis

Onodera¹,

Takenaka²,

Kozaki³

et al. 2016

International Journal of Oncology

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Abstract. We purified and identified eight xanthones from mangosteen (Garcinia mangostana L.) and investigated whether these compounds inhibited the activities of mammalian DNA polymerases (Pols) and human DNA topoisomerases (Topos). β-Mangostin was the strongest inhibitor of both mammalian Pols and human Topos among the isolated xanthones, with 50% inhibitory concentration (IC 50 ) values of 6.4-39.6 and 8.5-10 µM, respectively. Thermal transition analysis indicated that β-mangostin did not directly bind to double-stranded DNA, suggesting that this compound directly bound the enzyme protein rather than the DNA substrate. β-Mangostin showed the strongest suppression of human cervical cancer HeLa cell proliferation among the eight compounds tested, with a 50% lethal dose (LD 50 ) of 27.2 µM. This compound halted cell cycle in S phase at 12-h treatment and induced apoptosis. These results suggest that decreased proliferation by β-mangostin may be a result of the inhibition of cellular Pols rather than Topos, and β-mangostin might be an anticancer chemotherapeutic agent.

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Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana

Cited by 55 publications

References 25 publications

Naturally Occurring Xanthones: Chemistry and Biology

Naturally Occurring Xanthones: Chemistry and Biology

Bioactive Xanthones from Cratoxylum cochinchinense

Screening of mammalian DNA polymerase and topoisomerase inhibitors from Garcinia mangostana L. and analysis of human cancer cell proliferation and apoptosis

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