Xanthorrhizol contents, α-glucosidase inhibition, and cytotoxic activities in ethyl acetate fraction of Curcuma zanthorrhiza accessions from Indonesia

Nurcholis, Waras; Munshif, Ahmad Ajruddin; Ambarsari, Laksmi

doi:10.1016/j.bjp.2017.11.001

Cited by 34 publications

(30 citation statements)

References 31 publications

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“…All extracts were found to be toxic with LC 50 < 1000 mg/ml (Supraja et al, 2018). These results indicated the presence of potent cytotoxicity as anticancer on the RCA extracts (Nurcholis et al, 2016a) (Nurcholis et al, 2018). Ethanol extract (EE, LC 50 of 140.00 µg/ml) showed a signi icant cytotoxic effect compared with other extracts (Figure 8 and Figure 9) except with the acetone extract (AE, LC 50 of 199.63 µg/ml) at p < 0.05.…”

Section: Cytotoxic Activitymentioning

confidence: 84%

Optimization of extraction process for extract yields, total flavonoid content, radical scavenging activity and cytotoxicity of Curcuma aeruginosa RoxB. rhizome

Qomaliyah¹,

Artika²,

Nurcholis³

2019

ijrps

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The rhizome of Curcuma aeruginosa RoxB. (RCA) is used traditionally for several diseases. The flavonoid compounds contained in the RCA that responsible for biological activities. In this study, ethanol, water, and acetone had been used as solvent extraction of RCA and applied the simplex-centroid design to optimize the extraction process. The radical scavenging activity and total flavonoid content were investigated using in vitro assays, while cytotoxicity was evaluated by brine shrimp lethality test. ANOVA suggested a linear model for all responses. The ethanol: acetone extract had the highest extract yield with a value of 25.15%, and this result showed no significant with acetone extract at p < 0.05 (22.86%). The ethanol extracts confirmed the higher degree of total flavonoid content and cytotoxicity with a value of 17.97 mg QE/g and 140 μg/ml, respectively. The ethanol: water extract, ethanol extract, and water extract (IC50, 100-500 μg/ml) showed moderate radical scavenging activity compared with ascorbic acid (IC50, 7.19 μg/ml). Regarding the correlation analysis, the negative correlation was weakly observed between flavonoid content and IC50 of free radical scavenging activity, which indicates that the flavonoid in RCA contributes not significantly to the antioxidant activity. Introductory studies on the extraction process of the advanced flavonoid extracts exhibited a scavenging and cytotoxic effect of the ethanol extract on C. aeruginosa rhizome.

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Section: Cytotoxic Activitymentioning

confidence: 84%

Optimization of extraction process for extract yields, total flavonoid content, radical scavenging activity and cytotoxicity of Curcuma aeruginosa RoxB. rhizome

Qomaliyah¹,

Artika²,

Nurcholis³

2019

ijrps

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“…The ethyl acetate fractions of samples C. xanthorrhiza exhibited the highest cytotoxic activities, and all samples in cytotoxic activities were showed not significantly with the others in p≤0.05. The cytotoxicity of the ethyl acetate fractions in different sample rhizomes of C. zanthorrhiza was evaluated using the brine shrimp lethality test for potency in preliminary screening for cytotoxins as anticancer [47].…”

Section: Cytotoxicity Activitymentioning

confidence: 99%

An Overview of Medicinal Value of Curcuma Species

Kanase¹,

Khan²

2018

Asian J Pharm Clin Res

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Curcuma is a genus of about 100 accepted species in the family Zingiberaceae that contains such species as turmeric and Siam tulip. They are native to Southeast Asia, southern China, ISSN (Online): 2319-7064 ISSN (Online): 2319-7064 naturalized in other warm parts of the world such as Tropical Africa, Central America, Florida, and various islands of the Pacific, Indian, and Atlantic Oceans. Few known species of Curcuma with reported pharmacological activity are Curcuma longa, Curcuma aeruginosa, Curcuma pseudomontana, Curcuma aromatica, Curcuma xanthorrhiza, Curcuma zedoaria, Curcuma angustifolia. Among them, C. longa is the one species extensively studied and has ancient traditional medicinal uses. These Curcuma species have been used in traditional medicine as a household remedy for various diseases, including biliary disorders, anorexia, cough, diabetic wounds, hepatic disorders, rheumatism, and sinusitis. For the past few decades, extensive work has been done to establish the biological activities and pharmacological actions of Curcuma species and its extracts. This review article is created with an intention to give an overview on the reported research carried out on the Curcuma species such as anticancer activity, antitumor, antitubercular, antibacterial, antimicrobial, toxicity activity, and wound healing. And also, these Curcuma species can be considered as herbal medicinal plant having a plethora of research opportunities based on its traditional use and biological activity.

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“…FTIR (KBr) υmax cm −1 : 3482 (O-H), 2932, 2971 (CH aliphatic), 1762 (C=O ester), 1710 (C=O ketone), 1217 (C-O ester) [14]. 1 Supplementary Materials: The following are available online, Figure S1: FTIR of the title compound 2, Figure S2:…”

Section: Synthesis Of the Title Compoundmentioning

confidence: 99%

“…Xanthorrhizol, 2-methyl-5-[(2R)-6-methylhept-5-en-2-yl]phenol, is a major component extracted from Curcuma xanthorrhiza Roxb (Java turmeric) rhizomes. It has been established to have a variety of biological activities such as anticancer, anti-inflammatory, anticandidal, anti-hyperglycaemic, antibacterial, antioxidant, and anti-hypertensive [1][2][3][4][5][6][7][8][9]. Several xanthorrizol derivatives have been synthesized such as by esterification of the hydroxyl group, bromination of the phenyl ring, and epoxidation, asymmetric dihydroxylation, or hydrogenation of the carbon-carbon double bond of the compound [10,11].…”

Section: Introductionmentioning

confidence: 99%

5-(6-Hydroxy-6-methyl-5-oxoheptan-2-yl)-2-methyl Phenyl Acetate

Rahayu

Kusumaningrum²,

Hayun

2018

Molbank

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We synthesized a novel compound, 5-(6-hydroxy-6-methyl-5-oxoheptan-2-yl)-2-methylphenyl acetate, in a good yield by oxidation of 1-O-acetyl-xanthorrizol using potassium permanganate in acidic condition. The structure was elucidated by Fourier Transform Infrared (FTIR), 1H-Nuclear Magnetic Resonance (NMR) and 13C-NMR, two-dimensional (2D)-HSQC, Distortionless Enhancement by Polarization Transfer (DEPT), 2D-Heteronuclear Multiple Bond Correlation (HMBC), and High-Resolution Mass Spectra (HRMS) spectral data.

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Xanthorrhizol contents, α-glucosidase inhibition, and cytotoxic activities in ethyl acetate fraction of Curcuma zanthorrhiza accessions from Indonesia

Cited by 34 publications

References 31 publications

Optimization of extraction process for extract yields, total flavonoid content, radical scavenging activity and cytotoxicity of Curcuma aeruginosa RoxB. rhizome

Optimization of extraction process for extract yields, total flavonoid content, radical scavenging activity and cytotoxicity of Curcuma aeruginosa RoxB. rhizome

An Overview of Medicinal Value of Curcuma Species

5-(6-Hydroxy-6-methyl-5-oxoheptan-2-yl)-2-methyl Phenyl Acetate

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