Xeno-oestrogens and phyto-oestrogens induce the synthesis of leukaemia inhibitory factor by human and bovine oviduct cells

Reinhart, Karin C.; Dubey, Raghvendra K.; Keller, Paul J.; Lauper, Urs; Rosselli, Marinella

doi:10.1093/molehr/5.10.899

Cited by 29 publications

(9 citation statements)

References 61 publications

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“…The earliest evidence that naturally occurring phytoestrogens could cause reproductive disturbances in mammals was reported in 1946 by Bennetts et al [10] indicating that ingestion of clover pasture rich in plant estrogens caused infertility in sheep. About 20 years later, a similar observations had been noted in cows that had fertility disturbances resulting from periods of feeding with red clover [11, 12]. Similarly, abnormalities in reproductive health due to high intake of soy products have been reported in women [13–16].…”

Section: Introductionsupporting

confidence: 54%

Diverse Effects of Phytoestrogens on the Reproductive Performance: Cow as a Model

Wocławek-Potocka

Mannelli

Boruszewska

et al. 2013

International Journal of Endocrinology

106

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Phytoestrogens, polyphenolic compounds derived from plants, are more and more common constituents of human and animal diets. In most of the cases, these chemicals are much less potent than endogenous estrogens but exert their biological effects via similar mechanisms of action. The most common source of phytoestrogen exposure to humans as well as ruminants is soybean-derived foods that are rich in the isoflavones genistein and daidzein being metabolized in the digestive tract to even more potent metabolites—para-ethyl-phenol and equol. Phytoestrogens have recently come into considerable interest due to the increasing information on their adverse effects in human and animal reproduction, increasing the number of people substituting animal proteins with plant-derived proteins. Finally, the soybean becomes the main source of protein in animal fodder because of an absolute prohibition of bone meal use for animal feeding in 1995 in Europe. The review describes how exposure of soybean-derived phytoestrogens can have adverse effects on reproductive performance in female adults.

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Section: Introductionsupporting

confidence: 54%

Diverse Effects of Phytoestrogens on the Reproductive Performance: Cow as a Model

Wocławek-Potocka

Mannelli

Boruszewska

et al. 2013

International Journal of Endocrinology

106

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“…ER-affinity ERa-affinity ERb-affinity AhR-affinity Oestradiol +++++ +++++ +++++ nda (Kuiper et al, 1998) (Kuiper et al, 1998) Kuiper et al, 1998 Xeno-oestrogens TCDD ± ± ± ++++ (Lu et al, 1996) PCBs +/++ nda nda +++ (209 possible congeners) (Kafafi et al, 1993;Reinhart et al, 1999) Safe, 1994; Rowlands and Mekenyan, 1996;) 4-OH-PCB ++ + + nda (Korach et al, 1988;(Kuiper et al, 1998) (Kuiper et al, 1998) Kuiper et al, 1998Kramer and Giesy, 1999;Reinhart et al, 1999) Phyto-oestrogens Genistein +++ +++ +++ nda (Miksicek, 1993;(Kuiper et al, 1998) (Kuiper et al, 1998Reinhart et al, 1999) Equol ++ nda nda nda (Petit et al, 1997; Daidzein ++ ++ ++ nda (Markiewicz et al, 1993;(Kuiper et al, 1998) (Kuiper et al, 1998) Miksicek, 1995Hopert et al, 1998) Quercetin + + + +++ (Kuiper et al, 1998) ( Kuiper et al, 1998) (Kuiper et al, 1998) (Kuiper et al, 1998 Data from various cell types. nda = no data available; PCB = polychlorinated biphenyls; TCDD = 2,3,7,8-tetrachlorodibenzo-p-dioxin.…”

Section: Compoundmentioning

confidence: 99%

“…Moreover, the stimulatory effects of both phyto-oestrogens and xeno-oestrogens were completely blocked by the presence of ICI182780, suggesting that xeno-oestrogens can, under these in-vitro conditions, induce their effects on LIF synthesis via the ER. In contrast to oestradiol and xenooestrogens, tamoxifen (an ER ligand) also induces LIF synthesis in the oviduct cells; moreover, these effects are enhanced by oestradiol, suggesting that these effects are not ER-mediated but rather occur via an alternative mechanism (Reinhart et al, 1999). LIF is a glycoprotein essential for embryo implantation, development and differentiation.…”

Section: Xeno-oestrogensmentioning

confidence: 99%

Cellular and biochemical mechanisms by which environmental oestrogens influence reproductive function

Rosselli

Reinhart

Imthurn³

et al. 2000

Human Reproduction Update

100

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The biology and physiology of the male as well as female reproductive system is hormonally regulated. Abnormalities in the dynamics of hormone production, metabolism and elimination, as well as their binding to certain target tissues, has been associated with pathophysiological conditions of the reproductive system. Although oestrogens are known to be one of the major hormone groups in regulating the reproductive function and the fertilization process, the cellular and biochemical mechanism or mechanism(s) via which oestrogens induce their effects are still not fully defined. Moreover, in a modern environment we are also exposed to a wide battery of environmental agents which are structurally similar to oestrogens, and termed 'environmental oestrogens'. Because environmental oestrogens have been shown to mimic some of the effects of oestradiol, it has been postulated that these exogenous chemicals may influence or interfere with the oestrogen-dependent reproductive processes, and may be associated with beneficial as well as deleterious effects on the reproductive system. In this regard, two classes of environmental oestrogens have been widely studied, i.e. phyto-oestrogens (plant-derived dietary oestrogens) and xeno-oestrogens (industrial chemicals, including polychlorinated biphenyls, DDT, TCDD, dioxins, etc.). The main focus of this review is to provide an overview on the cellular and biochemical mechanism(s) by which xeno-oestrogens and phyto-oestrogens influence the oestrogen-dependent reproductive functions and induce their deleterious or protective effects on the reproductive system.

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“…1995). Phytoestrogens or their metabolites decrease the release of LH (Reinhart et al. 1999), and inhibit the response of granulosa cells on influence of gonadotropins (Zdunczyk et al.…”

Section: Introductionmentioning

confidence: 99%

The Adverse Effect of Phytoestrogens on the Synthesis and Secretion of Ovarian Oxytocin in Cattle

Mlynarczuk

Wróbel

Kotwica

2011

Reprod Domestic Animals

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The current investigations were undertaken to study the mechanism of the adverse effect of phytoestrogens on the function of bovine granulosa (follicles >1< cm in diameter) and luteal cells from day 1-5, 6-10, 11-15, 16-19 of the oestrous cycle. The cells were incubated with genistein, daidzein or coumestrol (each at the dose of 1 × 10(-6) m). The viability and secretion of estradiol (E2), progesterone (P4) and oxytocin (OT) were measured after 72 h of incubation. Moreover, the expression of mRNA for neurophysin-I/OT (NP-I/OT; precursor of OT) and peptidyl-glycine-α-amidating monooxygenase (PGA, an enzyme responsible for post-translational OT synthesis) was determined after 8 h of treatment. None of the phytoestrogens used affected the viability of cells except for coumestrol. The increased secretion of E2 and P4 was only obtained by coumestrol (p<0.05) from granulosa cells from follicles <1cm in diameter and decreased from luteal cells on days 11-15 of the oestrous cycle, respectively. All three phytoestrogens stimulated (p<0.05) OT secretion from granulosa and luteal cells in all stages of the oestrous cycle and the expression of NP-I/OT mRNA in the both types of cells. The expression of mRNA for PGA was stimulated (p<0.05) by daidzein and coumestrol in granulosa cells, and by genistein and coumestrol in luteal cells. In conclusion, our results demonstrate that these phytoestrogens can impair the ovary function in cattle by adversely affecting the synthesis of OT in follicles and in corpus luteum. However, their influence on the ovarian steroids secretion was less evident.

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Xeno-oestrogens and phyto-oestrogens induce the synthesis of leukaemia inhibitory factor by human and bovine oviduct cells

Cited by 29 publications

References 61 publications

Diverse Effects of Phytoestrogens on the Reproductive Performance: Cow as a Model

Diverse Effects of Phytoestrogens on the Reproductive Performance: Cow as a Model

Cellular and biochemical mechanisms by which environmental oestrogens influence reproductive function

The Adverse Effect of Phytoestrogens on the Synthesis and Secretion of Ovarian Oxytocin in Cattle

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