Xenobiotic Metabolizing Genes, Meat-Related Exposures, and Risk of Advanced Colorectal Adenoma

Ferrucci, Lea M; Cross, Amanda J.; Gunter, Marc J.; Ahn, Jiyoung; Mayne, Susan T.; Ma, Xiaomei; Chanock, Stephen J.; Yeager, Meredith; Graubard, Barry I.; Berndt, Sonja I.; Huang, Wen Yi; Hayes, Richard B.; Sinha, Rashmi

doi:10.1159/000324351

Cited by 4 publications

(4 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Positive associations have been reported to be due to genetic differences. Specific genetic polymorphisms [ 8 ], xenobiotic metabolizing genes [ 9 ] and genetic susceptibility [ 10 ] have all been implicated in the pathogenesis of CRC. Finally, colorectal adenomashave been deemed to be a significant risk factor of CRC [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Red and processed meat consumption and colorectal cancer risk: a systematic review and meta-analysis

et al. 2017

View full text Add to dashboard Cite

The associations between red and processed meat consumption and the risk of colorectal cancer types have not been conclusively defined. We performed a systematic review and meta-analysis to analyze these associations. We searched PubMed and EMBASE to identify studies published from inception through September 2016. Dose-response, subgroup and subtype analyses of colorectal cancer (colon cancer, proximal colon cancer, distal colon cancer and rectal cancer) were performed. We ultimately selected 60 eligible studies. Positive associations were observed for colorectal cancer in case-control studies (red meat, P<0.01; processed meat, P<0.01) and cohort studies (red meat, P<0.01; processed meat, P<0.01). However, subtype analyses yielded null results for distal colon cancer in case-control studies (P=0.41) and cohort studies (P=0.18) for red meat and null results for proximal colon cancer in case-control studies (P=0.13) and cohort studies (P=0.39) for processed meat. Additionally, although the results of case-control studies were positive (red meat, P<0.01; processed meat, P=0.04) for rectal cancer, there were no positive associations between red (P=0.34) and processed meat (P=0.06) consumption and the risk in cohort studies. In a systematic review and meta-analysis, we found consumption of red and processed meat was associated with the risk of overall colorectal cancer but not rectal cancer. Additionally, there were no associations between the consumption of red meat and distal colon cancer risk and between the consumption of processed meat and proximal colon cancer risk.

show abstract

Section: Discussionmentioning

confidence: 99%

Red and processed meat consumption and colorectal cancer risk: a systematic review and meta-analysis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Single nucleotide polymorphisms (SNPs) in the genes encoding these XMEs may modify the ability to activate or detoxify carcinogens. Previous studies examining interactions between XME polymorphisms, meat consumption and the risk of colorectal adenomas or carcinomas have reported mixed results (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). In addition, most previous studies had a small number of cases or examined only a small set of SNPs from a limited number of candidate genes.…”

Section: Introductionmentioning

confidence: 99%

Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer

et al. 2012

Self Cite

View full text Add to dashboard Cite

Meat mutagens, including heterocyclic amines (HCAs), polycyclic aromatic hydrocarbons (PAHs) and N-nitroso compounds (NOCs), may be involved in colorectal carcinogenesis depending on their activation or detoxification by phase I and II xenobiotic metabolizing enzymes (XME). Using unconditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI), we examined the intake of five meat mutagens and >300 single nucleotide polymorphisms (SNPs) in 18 XME genes in relation to advanced colorectal adenoma (1205 cases and 1387 controls) and colorectal cancer (370 cases and 401 controls) within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Dietary intake of meat mutagens was assessed using a food frequency questionnaire with a detailed meat-cooking module. An interaction was observed between 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) intake and the NAT1 polymorphism rs6586714 in the adenoma study (P(interaction) = 0.001). Among individuals carrying a GG genotype, high MeIQx intake was associated with a 43% increased risk of adenoma (95% CI 1.11-1.85, P(trend) = 0.07), whereas the reverse was observed among carriers of the A variant (OR = 0.50, 95% CI 0.30-0.84, P(trend) = 0.01). In addition, we observed some suggestive (P < 0.05) modifying effects for SNPs in other XME genes (UGT1A, CYP2E1, EPHX1, AHR and GSTM3), but these were not significant after adjustment for multiple testing. This large and comprehensive study of XME genes, meat mutagens and the risk of colorectal tumours found that a NAT1 polymorphism modified the association between MeIQx intake and colorectal adenoma risk.

show abstract

“…However, in certain events, the metabolism of xenobiotic compounds may produce reactive or carcinogenic intermediates that are harmful to the cells. HCAs, PAHs and NOCs are meat-derived procarcinogenic agents that require metabolic activation and conjugation by wide range of xenobiotic metabolism enzymes (XMEs) of Phase I and II to turn into genotoxic-carcinogens [17,18]. Genotoxic carcinogens are agents capable of inducing DNA lesions.…”

Section: Role Of Xenobiotic Metabolism Pathwaymentioning

confidence: 99%

“…Supplementary Table 1 summarizes some of the polymorphic variations in the xenobiotic metabolizing genes that may play role in cancers susceptibility. In general, there is little consensus in the literature for XME gene-meat interactions in relation to cancer susceptibility for CYP1A1, CYP1A2, CYP1B1 [18,[30][31][32], CYP2E1 [18,30,31], EPHX1 [18,30,[32][33][34], NAT1 and NAT2 [18,30,32,35,36] or SULT1A1 [30,35] phenotypes. In addition, there are limited data on AMACR [37], SULT2A1 [33] and RAPTOR [38].…”

Section: Genetic Polymorphisms Of Xenobiotic Metabolizing Genesmentioning

confidence: 99%

Review on Variants in Genes Associated with Cancer Risk and Red Meat Metabolism

Àlex¹

2013

J. Nutr. Ther.

View full text Add to dashboard Cite

With the advent of human genome sequencing project, came the wave of personalized genomics. Scientists have now gone beyond scanning of individual genes and epigenetic variations that might alter an individual's predisposition to developing complex diseases. Nutritional genomics is a science which is fast catching up. Efforts to explain the diet-gene interactions often recapitulate the effects of genetic makeup in determining the exact fate of the meal we ate last.Diet-gene interactions play a major role in the metabolism and detoxification of food-derived mutagens and carcinogens. Heterocyclic amines (HCAs), polycyclic aromatic hydrocarbons (PAHs), and N-nitroso compounds (NOCs) are a class of mutagens or carcinogens found in red and processed meat that can lead to various types of cancers. Harboring unfavourable mutations or single nucleotide polymorphisms (SNPs) involved in metabolism of HCAs, PAHs, and NOCs can promote cancers. Increasing risks of several types of cancers, such as cancer of the colorectum, breast, prostate, esophagus, and lung, have been associated with high intake of red and processed meat. We attempt to compile some of the variants based on reports published during the past five years on variations involved in red meat metabolism which aims to provide useful insight in aiding us to regulate our red meat intake to avoid spurring of cancer.

show abstract

Xenobiotic Metabolizing Genes, Meat-Related Exposures, and Risk of Advanced Colorectal Adenoma

Cited by 4 publications

References 55 publications

Red and processed meat consumption and colorectal cancer risk: a systematic review and meta-analysis

Red and processed meat consumption and colorectal cancer risk: a systematic review and meta-analysis

Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer

Review on Variants in Genes Associated with Cancer Risk and Red Meat Metabolism

Contact Info

Product

Resources

About