Xenobiotic reduction and clinical improvements in capacitor workers: A feasible method

Tretjak, Ziga; Root, David E.; Tretjak, Ana; Slivnik, R.; Edmondson, Elijah F.; Graves, Reed A.; Beckmann, ShelleyL.

doi:10.1080/10934529009375594

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…Ideally, a future study would include biomarkers of GWI case status, such as serum autoantibodies [38], or other objective measures such as longer term follow-up changes in hippocampal microstructure [132]. Additionally, biomarkers should be obtained that would represent, in real time, the enhanced detoxification process such as changes in adipose, serum or skin lipids xenobiotic burden [51,52,133,134,135]. Another potential tool is measurement of concentrations of small molecular weight compounds in both serum and sweat before, during and after the regimen [136,137,138].…”

Section: Discussionmentioning

confidence: 99%

A Detoxification Intervention for Gulf War Illness: A Pilot Randomized Controlled Trial

Kerr

Morse

Graves

et al. 2019

IJERPH

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Approximately 30% of the 700,000 US veterans of the 1990–1991 Persian Gulf War developed multiple persistent symptoms called Gulf War illness. While the etiology is uncertain, several toxic exposures including pesticides and chemical warfare agents have shown associations. There is no effective medical treatment. An intervention to enhance detoxification developed by Hubbard has improved quality of life and/or reduced body burdens in other cohorts. We evaluated its feasibility and efficacy in ill Gulf War (GW) veterans in a randomized, waitlist-controlled, pilot study at a community-based rehabilitation facility in the United States. Eligible participants (n = 32) were randomly assigned to the intervention (n = 22) or a four-week waitlist control (n = 10). The daily 4–6 week intervention consisted of exercise, sauna-induced sweating, crystalline nicotinic acid and other supplements. Primary outcomes included recruitment, retention and safety; and efficacy was measured via Veteran’s Short Form-36 (SF-36) quality of life, McGill pain, multidimensional fatigue inventory questionnaires and neuropsychological batteries. Scoring of outcomes was blinded. All 32 completed the trial and 21 completed 3-month follow-up. Mean SF-36 physical component summary score after the intervention was 6.9 (95% CI; −0.3, 14.2) points higher compared to waitlist control and 11 of 16 quality of life, pain and fatigue measures improved, with no serious adverse events. Most improvements were retained after 3 months. The Hubbard regimen was feasible, safe and might offer relief for symptoms of GW illness.

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Section: Discussionmentioning

confidence: 99%

A Detoxification Intervention for Gulf War Illness: A Pilot Randomized Controlled Trial

Kerr

Morse

Graves

et al. 2019

IJERPH

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“…Although further study is required to determine the clinical usefulness of induced depuration through thermal techniques, several studies thus far have confirmed that induced perspiration through sauna therapy can diminish the body burden of assorted bioaccumulated toxicants including persistent polychlorinated biphenyls (PCBs), polybrominated biphenyls, chlorinated pesticides, hexachlorobenzene, and various other toxicants in exposed individuals. [73][74][75][76][77][78][79][80] Another recognized intervention to diminish the body burden of some bioaccumulated toxicants is the Recognized treatment for some types of heavy metal poisoning. 40,41 No evidence in the literature for removal of other types of toxicants Plasmapheresis…”

Section: Interventions To Facilitate Excretion Of Xenobioticsmentioning

confidence: 99%

Elimination of persistent toxicants from the human body

Genuis

2010

Hum Exp Toxicol

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There is compelling evidence that various chemical agents are important determinants of myriad health afflictions — several xenobiotics have the potential to disrupt reproductive, developmental, and neurological processes and some agents in common use have carcinogenic, epigenetic, endocrine-disrupting, and immune-altering action. Some toxicants appear to have biological effect at miniscule levels and certain chemical compounds are persistent and bioaccumulative within the human body. Despite escalating public health measures to preclude further exposures, many people throughout the world have already accrued a significant body burden of toxicants, placing them at potential health risk. As a result, increasing discussion is underway about possible interventions to facilitate elimination of persistent toxicants from the human organism in order to obviate health affliction and to potentially ameliorate chronic degenerative illness. An overview of the clinical aspects of detoxification is presented with discussion of established and emerging interventions for the elimination of persistent xenobiotics. Potential therapies to circumvent enterohepatic recirculation and a case report highlighting a clinical outcome associated with detoxification are also presented for consideration.

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“…In nearly 40 years of application of this regimen to occupational or environmental exposures, studies have shown statistically significant reductions in human chemical pollutants, including polychlorinated biphenyls (PCBs) and dioxins, 22,23 and subsequent improvements in health. 24,25 Kilburn et al 26 measured improvements in long-term memory, cognitive dysfunction and peripheral neuropathy among firefighters who completed sauna detoxification 6 months after PCB exposure from burning transformers. Tsyb et al 27 described the safety and long-term health improvements in clean-up workers after the Chernobyl disaster.…”

Section: Introductionmentioning

confidence: 99%

Safety and tolerability of sauna detoxification for the protracted withdrawal symptoms of substance abuse

Lennox

Cecchini-Sternquist

2018

J Int Med Res

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ObjectiveProtracted drug withdrawal symptoms can last months or years after drug cessation, often precipitating a return to substance misuse. We evaluated the safety and preliminary health benefits of a unique chemical exposure regimen based on exercise, sauna and therapeutic nutrients.MethodsThis was a prospective evaluation of 109 individuals sequentially enrolled into a sauna detoxification component of a multi-modal, long-term residential substance abuse treatment centre.ResultsData from medical charts, client self-reports and Short Form Health Survey (SF-36) responses indicated that the Hubbard sauna detoxification method was well tolerated, with a 99% completion rate, including one human immunodeficiency virus and nine hepatitis C positive clients. There were no cases of dehydration, overhydration or heat illness. Statistically significant improvements were seen in both mental and physical SF-36 scores at regimen completion, as well as in Addiction Severity Index and Global Appraisal of Individual Needs Short Screener change scores at rehabilitation program discharge, compared with enrolment.ConclusionsThe regimen lacked serious adverse events, had a very low discontinuation rate and high client-reported satisfaction. The SF-36 data indicated improved physical and emotional symptoms. Therefore, broader investigation of this sauna-based treatment regimen is warranted.

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Xenobiotic reduction and clinical improvements in capacitor workers: A feasible method

Cited by 5 publications

References 33 publications

A Detoxification Intervention for Gulf War Illness: A Pilot Randomized Controlled Trial

A Detoxification Intervention for Gulf War Illness: A Pilot Randomized Controlled Trial

Elimination of persistent toxicants from the human body

Safety and tolerability of sauna detoxification for the protracted withdrawal symptoms of substance abuse

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