Xenon Anesthesia in Pediatric Dental Interventions

Abstract

Introduction. Therapeutic dental manipulations in smaller children are usually done under general anesthesia and sedation using inhalation anesthetics due to their high psychoemotional lability. Xenon (inert gas) is of particular interest among inhalation anesthetic agents due to its unique pharmacological properties such as hypnotic and analgesic effect, lack of toxicity, organ protective properties, etc. Purpose is to estimate adequacy, safety and comfort with anesthesia in pediatric dentistry. Materials and methods. 30 children (18 boys and 12 girls) were involved in an open, prospective, randomized study. They obtained dental treatment for caries and pulpitis. Sevoflurane 8% and concentration of 60–70% xenon with О2 was given to induce anesthesia. Anesthesia adequacy, safety and comfort were estimated based on hemodynamics data, BIS index, concentrations of sevoflurane and xenon in the anesthetic gas, recovery time, rate of agitation, nausea and vomiting. Results. The study demonstrated safety of xenon gas anesthesia in pediatric dentistry. The estimated values were within the reference range. Following anesthesia, recovery occurred after 30 minutes, no single case of postanesthesia agitation, nausea and vomiting was noted. Conclusion. Xenon provides for high effectiveness and safety of anesthesia in pediatric dentistry. The results show that further studies are reasonable.

Inhalation anesthesia in children in outpatient dentistry: xenon or sevoflurane?

“…Применение ксенона в амбулаторной стоматологии у детей практически не изучено, хотя имеются данные о положительных результатах. Продемонстрированы стабильные показатели гемодинамики, вентиляции, кислотно-щелочного состояния, динамики BIS-индекса при стоматологическом лечении детей [13]. Имеются данные по безопасному применению ксенона у детей с различными хирургическими заболевания [14].…”