Introduction. Therapeutic dental manipulations in smaller children are usually done under general anesthesia and sedation using inhalation anesthetics due to their high psychoemotional lability. Xenon (inert gas) is of particular interest among inhalation anesthetic agents due to its unique pharmacological properties such as hypnotic and analgesic effect, lack of toxicity, organ protective properties, etc. Purpose is to estimate adequacy, safety and comfort with anesthesia in pediatric dentistry. Materials and methods. 30 children (18 boys and 12 girls) were involved in an open, prospective, randomized study. They obtained dental treatment for caries and pulpitis. Sevoflurane 8% and concentration of 60–70% xenon with О2 was given to induce anesthesia. Anesthesia adequacy, safety and comfort were estimated based on hemodynamics data, BIS index, concentrations of sevoflurane and xenon in the anesthetic gas, recovery time, rate of agitation, nausea and vomiting. Results. The study demonstrated safety of xenon gas anesthesia in pediatric dentistry. The estimated values were within the reference range. Following anesthesia, recovery occurred after 30 minutes, no single case of postanesthesia agitation, nausea and vomiting was noted. Conclusion. Xenon provides for high effectiveness and safety of anesthesia in pediatric dentistry. The results show that further studies are reasonable.

Abstract. The choice of optimal anesthetic in outpatient dental practice is an important stage in treatment plan preparation for children who need oral sanitation under general anesthesia. Few works were devoted to the comparative characterization of sevoflurane and xenon, especially in conditions of outpatient dental practice. Aim. This study aimed to compare the characteristics of xenon and sevoflurane inhalation anesthesia at the stage of maintaining anesthesia in outpatient dental practice. Materials and methods. This is an open, comparative, and randomized study, in parallel groups with random sampling. A total of 103 patients of both sexes aged 212 years were included. Children were divided into 2 groups: group 1 (35 children), with sevoflurane anesthesia and group 2 (68 children), with xenon anesthesia. In each and between groups at stages of anesthesia, data from the bispectral (BIS) index, heart rate, blood pressure, lung ventilation, glucose, acid-base status, and ionic composition of venous blood were monitored. Results. Significant differences between groups were observed in the BIS-index values at the end of anesthesia, indicating a faster awakening of patients under xenon anesthesia. Blood pressure and heart rate indicators in the xenon group at the beginning and end of the study are not statistically significant compared to the sevoflurane group. Remaining indicators did not show significant differences between groups. Conclusion. The use of sevoflurane and xenon during general anesthesia in outpatient dental practice characterized by the stability of the acid-base state, ion composition, and glucose concentration allows adequate conditions for spontaneous ventilation with pressure support. However, a faster awakening of the patient at the end was observed when using xenon. Diastolic blood pressure and heart rate in the xenon group after the end of anesthesia are close to baseline values.