Xenotransplantation's benefits outweigh risks

González, Rocío López

doi:10.1038/420268a

Cited by 8 publications

(2 citation statements)

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“…Each patient received a mean of three cellular infusions, with a total of 68. This study was conducted following protocol approved by the Investigation, Ethics and Biosafety Committees of both Mexico Children's Hospital Federico Gomez and the National Autonomous University of Mexico School of Medicine [22]. Patients were counselled on the procedure, the potential risks and possible benefits were fully discussed and, subsequently, a detailed signed Declaration of Helsinki compliant informed consent was obtained.…”

Section: Methodsmentioning

confidence: 99%

Correlation between insulin requirements and anti-galactose antibodies in patients with type 1 diabetes transplanted with neonatal pig islets

Esquivel-Perez

Rodríguez-Ventura

Dorantes

et al. 2011

Clinical and Experimental Immunology

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SummaryPig xenografts represent an alternative source of organs for transplantation. Immunosuppression can prevent rejection, but involves high risk and cost. New anti-rejection techniques have been developed; however, results have not been successful. Few studies have reported xenoantibody levels in xenotransplanted patients with diabetes and no patients have reported a clinical correlation. We analysed anti-galactose (Gal) and other anti-pig antibody (APA) levels in xenotransplanted patients with type 1 diabetes and the relation to the clinical outcome. Twenty-three patients with type 1 diabetes were transplanted with porcine islets inside a device without immunosuppression. Demographic characteristics, insulin dose and xenoantibody levels at different periods were recorded. Anti-Gal and anti-pig antibodies were measured through indirect enzyme-linked immunosorbent assay (ELISA) and haemolytic anti-pig antibody assay. More than 50% were female; the mean current age, current diabetes duration, diabetes duration at xenotransplantation and time post-transplantation were: 20·8, 11, 5·5 and 5·7 years, respectively. Insulin doses remained with a mean reduction greater than 33% in more than 50% of the patients. The lowest anti-Gal antibody levels were related to the highest insulin dose reductions. This relationship could be explained by the device, Sertoli cells and accommodation process.

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Section: Methodsmentioning

confidence: 99%

Correlation between insulin requirements and anti-galactose antibodies in patients with type 1 diabetes transplanted with neonatal pig islets

Esquivel-Perez

Rodríguez-Ventura

Dorantes

et al. 2011

Clinical and Experimental Immunology

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show abstract

“…The concerns expressed by Drs Sykes and Cozzi have already been raised in other publications and we have responded to them (1,2). In particular, we would like to point out that this trial started in 2000, and therefore we are surprised that the authors would be concerned that at that time we did not follow their own position papers published in 2003 and 2004.…”

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confidence: 90%

Reply to Sykes and Cozzi: ‘Xenotransplantation of porcine neonatal islets of Langerhans and Sertolli cells’

Valdés-González¹

2006

eur j endocrinol

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Prolonged gene expression in primary porcine pancreatic cells using an Epstein–Barr virus-based episomal vector

Min¹,

Oh²,

Yoon³

et al. 2003

Biochemical and Biophysical Research Communications

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Xenotransplantation's benefits outweigh risks

Cited by 8 publications

References 0 publications

Correlation between insulin requirements and anti-galactose antibodies in patients with type 1 diabetes transplanted with neonatal pig islets

Correlation between insulin requirements and anti-galactose antibodies in patients with type 1 diabetes transplanted with neonatal pig islets

Reply to Sykes and Cozzi: ‘Xenotransplantation of porcine neonatal islets of Langerhans and Sertolli cells’

Prolonged gene expression in primary porcine pancreatic cells using an Epstein–Barr virus-based episomal vector

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