Xerostomia and hyposalivation in patients with obstructive sleep apnoea

Abstract

Objective (a) To report the xerostomia prevalence and severity in patients with obstructive sleep apnoea (OSA). (b) To assess the saliva pH in patients with OSA. Design Simultaneous cohort observational clinical study. Setting In Sleep Medicine Centre at Lomonosov Moscow State University from March to June 2019. Participants The study was conducted on 30 patients with OSA aged from 35 to 65 years. Main outcomes measures The diagnosis of sleep apnoea was made after standard polysomnography using the Domino programme. The severity of OSA was indicated using the Apnoea‐Hypopnea Index. Xerostomia was evaluated using Fox's test. Hyposalivation was evaluated by measurement of salivary flow rate. Determination of the saliva pH was carried out with a pH metre. Statistical analysis was performed by one‐way ANOVA and Tukey‐Kramer multi‐comparison test. Results Twenty‐two out of 30 (73.3%) patients were diagnosed with "dry mouth". Hyposalivation was observed in 6 out of 30 (20%). Dry mouth on awakening was observed in 60.0%, 72.7% and 88.9% of patients with mild, moderate and severe OSA, respectively. The average salivary flow rate was 0.28 mL/min, 0.24 mL/min and 0.14 mL/min, respectively. The average pH value in patients with mild, moderate and severe apnoea was 6.40 ± 0.017, 6.15 ± 0.27 and 5.87 ± 0.24, respectively. Conclusions In patient with mild and moderate OSA, the saliva amount and rate are similar (P > .05). With the increase of OSA severity, both these parameters change (P < .001). The acidity of the saliva was correlated with the level of OSA, and it statistically increased with the increment of the OSA severity (P < .05‐P < .001).

Salivary trefoil factor family peptide 3 (TFF3) and flow rate in persons with and without obstructive sleep apnea: A preliminary study

“…The average pH value in patients with mild, moderate, and severe apnea was 6.40 ± 0.017, 6.15 ± 0.27, and 5.87 ± 0.24, respectively. The acidity of the saliva was correlated with the level of OSA, and it is statistically increased with the increment of the OSA severity (Makeeva et al, 2021 ).…”

Perspective chapter: Role of the Oral Healthcare Team in the Management of Obstructive Sleep Apnea

“…They further demonstrated that dry mouth upon awakening is a common symptom with OSA and 22 (73.3%) of the 30 patients evaluated had dry mouth and the prevalence of sleep-related xerostomia is correlated with OSA severity. In the majority of patients, dry mouth was correlated with mouth breathing and not salivary hypofunction and only 20% of the patients exhibited objective signs of hyposalivation [41].…”

The Effect of Aging on Artificial Saliva at Different pH Values on the Color Stability of New Generation Denture Base Materials

“…The alkalinity of saliva also increases with dysfunctions such as certain foodstuffs consumed, enzyme and secretion production of the pancreas, and liver problems. Although the disruptions of the pH balance to which the oral environment is exposed by the foods consumed can be limited by diet, saliva pH changes caused by the medications and diseases used by the patients cannot be prevented [ 6 , 7 ].…”