2019
DOI: 10.1016/j.biopha.2019.109442
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Xiaoerfupi alleviates the symptoms of functional dyspepsia by regulating the HTR3A and c-FOS

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Cited by 15 publications
(7 citation statements)
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“…We used BATMAN-TCM (http://bionet.ncpsb.org.cn/batmantcm/) (Ji et al, 2019) and the SwissTargetPrediction database (http://www.swisstargetprediction.ch/) (Gfeller et al, 2014) to identify the relevant biological targets of candidate ingredients from ZSS. We also retrieved disease-associated targets from the GeneCards database (https://www.genecards.org/) by using "insomnia" and "sedation and hypnosis" as keywords (Hu et al, 2020).…”
Section: Analysis Of Putative Targetsmentioning
confidence: 99%
“…We used BATMAN-TCM (http://bionet.ncpsb.org.cn/batmantcm/) (Ji et al, 2019) and the SwissTargetPrediction database (http://www.swisstargetprediction.ch/) (Gfeller et al, 2014) to identify the relevant biological targets of candidate ingredients from ZSS. We also retrieved disease-associated targets from the GeneCards database (https://www.genecards.org/) by using "insomnia" and "sedation and hypnosis" as keywords (Hu et al, 2020).…”
Section: Analysis Of Putative Targetsmentioning
confidence: 99%
“…Six constituent herbs in XYS were submitted to BATMAN-TCM (http://bionet.ncpsb.org/batman-tcm) to discover their therapeutic mechanisms. After the ingredients in the herbs were identified, the candidate targets were calculated by the similarity-based target prediction method [38] . Putative targets were predicted because the score cutoff was >30.…”
Section: Methodsmentioning
confidence: 99%
“…In some clinical trials in patients with GID, TCM has demonstrated efficacy ( Wu et al, 2011 ; Chen et al, 2020 ; Xu et al, 2020 ). Xiaoerfupi (XEFP) granule is a TCM that is composed of six medicinal plant-derived natural products ( Ji et al, 2019 ), including Atractylodes macrocephala , Pericarpium citri reticulatae , Poria coss , Codonopsis pilosula , Crataegus pinnatida , and Nelumbo nuclefera . Due to its favourable clinical efficacy and accessibility, XEFP has become a common aqueous decoction for treating GID and alleviating GID symptoms in China.…”
Section: Introductionmentioning
confidence: 99%
“…Due to its favourable clinical efficacy and accessibility, XEFP has become a common aqueous decoction for treating GID and alleviating GID symptoms in China. In a previous work, we performed a pharmacodynamic evaluation ( Ji et al, 2019 ) of XEFP and predicted its potential targets ( Wei et al, 2019 ), but whether XEFP influences the intestinal flora and the affected microbiota and corresponding mechanism have not yet been reported.…”
Section: Introductionmentioning
confidence: 99%