XpII.2 Translocation Renal Carcinoma With Placental Metastasis: A Case Report

Bovio, Ian; Allan, Robert W.; Oliai, Bahram R.; Hampton, Troy; Rush, Demaretta S.

doi:10.1177/1066896908331231

Cited by 14 publications

(13 citation statements)

References 14 publications

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“…To the best of our knowledge, the case herein presented is the first report of Xp11.2 translocation RCC occurring during pregnancy. Bovio et al [ 23 ] recently reported the case of a 20-year-old pregnant female with placental, bone and retroperitoneal lymph node metastases two years after radical nephrectomy for Xp11.2 translocation RCC, but no evidence of fetal metastasis. Hence, the initial diagnosis of Xp11.2 translocation RCC occurred prior to her pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, the initial diagnosis of Xp11.2 translocation RCC occurred prior to her pregnancy. Bovio et al [ 23 ] stated that given the need for systemic therapy and risk of harm to the fetus, a Cesarean section was performed at 33 weeks gestation. However, they did not specify whether subsequent systemic therapy was given, what specific type of systemic therapy was given (if any), the fate of the bone and retroperitoneal lymph node metastases, and the final patient outcome (whether she was alive with no evidence of disease, was alive with progressive disease, or died of disease).…”

Section: Discussionmentioning

confidence: 99%

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Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature

Armah

Parwani

Surti

et al. 2009

Diagnostic Pathology

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The recently recognized renal cell carcinomas (RCCs) associated with Xp11.2 translocations (TFE3 transcription factor gene fusions) are rare tumors predominantly reported in children. They comprise at least one-third of pediatric RCCs and only few adult cases have been reported. Here, we present a case of Xp11.2 translocation RCC in 26-year-old pregnant female. Her routine antenatal ultrasonography accidentally found a complex cystic right renal mass. Further radiologic studies revealed unilocular cyst with multiple mural nodules at inferior pole of right kidney, which was suspicious for RCC. She underwent right radical nephrectomy at 15 weeks gestation. Macroscopically, the cystic tumor was well encapsulated with multiple friable mural nodules on its inner surface. Microscopically, the tumor consisted of clear and eosinophilic/oncocytic voluminous cells arranged in papillary, trabecular, and nested/alveolar patterns. Occasional hyaline nodules and numerous psammoma bodies were present.Immunohistochemically, the tumor showed strong nuclear positivity for TFE3. Epithelial membrane antigen, CD10, and E-cadherin were strongly positive. Cytokeratin AE1/AE3, cytokeratin CAM-5.2, calveolin, and parvalbumin were moderately positive. Cytokeratin 7, renal cell carcinoma antigen, and colloidal iron were focally weakly positive. BerEP4 and carbonic anhydrase IX were negative. Cytogenetically, the tumor harbored a novel variant translocation involving chromosomes X and 19, t(X;19)(p11.2;q13.1). Interphase FISH analysis performed on cultured and uncultured tumor cells using a dual-color break-apart DNA probe within the BCL3 gene on 19q13.3 was negative for the BCL3 gene rearrangement. She received no adjuvant therapy, delivered a normal term baby five months later, and is alive without evidence of disease 27 months after diagnosis and surgery. Unlike most recently reported Xp11.2 translocation RCCs in adult patients with aggressive clinical course, this adult case occurring during pregnancy with a novel translocation involving chromosome 19 followed an indolent clinical course.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature

Armah

Parwani

Surti

et al. 2009

Diagnostic Pathology

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“… 2 Genetic abnormalities have also been detected in development of RCC, especially Xp 11.2 translocation, which is the most common mutation. 4 …”

Section: Discussionmentioning

confidence: 99%

“…The characteristics of patients who were diagnosed with RCC during the antenatal period, and the surgical and pregnancy outcomes from 2004 to the present day are shown in Table 1 . 4 , 6 – 21 …”

Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma diagnosed during pregnancy: a case report and literature review

et al. 2018

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Diagnosing cancer during pregnancy is uncommon. Although pregnancies with concomitant malignancies have been reported, urological tumours are possibly the most rarely identified tumours during pregnancy. Renal cell carcinoma appears to be the most common urological malignancy during pregnancy. In this case report, we discuss successful management of a patient who was diagnosed with renal cell carcinoma during the antenatal period.

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“…Several case reports and reviews are also available concerning the challenges associated with kidney cancers diagnosed in pregnant women [ 15 – 22 ]. However, there is only limited knowledge about the behavior of metastatic renal cell carcinoma during pregnancy so far [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

A case study on the potential angiogenic effect of human chorionic gonadotropin hormone in rapid progression and spontaneous regression of metastatic renal cell carcinoma during pregnancy and after surgical abortion

et al. 2015

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BackgroundTreatment possibilities of metastatic renal cell carcinoma (mRCC) have recently changed dramatically prolonging the overall survival of the patients. This kind of development brings new challenges for the care of mRCC.Case presentationA 22 year-old female patient with translocation type mRCC, who previously had been treated for nearly 5 years, became pregnant during the treatment break period. Follow-up examinations revealed a dramatic clinical and radiological progression of mRCC in a few weeks therefore the pregnancy was terminated. A few days after surgical abortion, CT examination showed a significant spontaneous regression of the pulmonary metastases, and the volume of the largest manifestation decreased from ca. 30 to 3.5 cm3 in a week. To understand the possible mechanism of this spectacular regression, estrogen, progesterone and luteinizing hormone receptors (ER, PGR and LHR, respectively) immuno-histochemistry assays were performed on the original surgery samples. Immuno-histochemistry showed negative ER, PGR and positive LHR status suggesting the possible angiogenic effect of human chorionic gonadotropin hormone (hCG) in the background.ConclusionWe hypothesize that pregnancy may play a causal role in the progression of mRCC via the excess amount of hCG, however, more data are necessary to validate the present notions and the predictive role of LHR overexpression.

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XpII.2 Translocation Renal Carcinoma With Placental Metastasis: A Case Report

Cited by 14 publications

References 14 publications

Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature

Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature

Renal cell carcinoma diagnosed during pregnancy: a case report and literature review

A case study on the potential angiogenic effect of human chorionic gonadotropin hormone in rapid progression and spontaneous regression of metastatic renal cell carcinoma during pregnancy and after surgical abortion

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