XRCC1 gene polymorphisms and esophageal squamous cell carcinoma risk in Chinese population: A meta‐analysis of case–control studies

Abstract

Two non-synonymous polymorphisms Arg194Trp and Arg399Gln in the DNA-base excision repair gene X-ray repair cross-complementing group 1 (XRCC1) have been implicated in risk for esophageal cancer. However, the results from different studies remain controversial. The present meta-analysis of literatures was performed to clarify these associations in Chinese population. A comprehensive literature search was conducted to identify all case-control studies of XRCC1 polymorphisms Arg194Trp and Arg399Gln and risk for esophageal squamous cell carcinoma (ESCC). A total of 9 eligible studies, including 1,538 ESCC cases and 2,472 controls, were identified to the meta-analysis. The odds ratio (OR) for the variant homozygous genotype Trp/Trp of the Arg194Trp polymorphism, compared with the wild-type homozygote Arg/Arg, was 1.59 (p 5 0.0007), with 95% confidence interval (95% CI) 1.22-2.09, for ESCC risk without between-study heterogeneity. However, there was no statistically significant associations of ESCC risk in the dominant model Arg/Trp1Trp/Trp (OR 0.97; 95% CI 0.84-1.12; p 5 0.69) and heterozygous genotype Arg/Trp (OR 0.90; 95% CI 0.77-1.04; p 5 0.16) when comparing with wild-type genotype Arg/Arg. For Arg399Gln, there was no effect in dominant modeling (Arg/Gln1Gln/Gln vs. Arg/Arg: OR 0.92; 95% CI 0.80-1.06; p 5 0.25), and the variant Gln/Gln homozygote was not associated with ESCC risk (OR 1.29; 95% CI 0.79-2.10; p 5 0.31), either. In conclusion, Arg194Trp genetic polymorphism may be associated with an increased risk for developing ESCC and a study with the larger sample size is needed to further evaluate gene-environment interaction on XRCC1 polymorphisms and ESCC risk. ' 2009 UICC

Meta-analysis demonstrates association of XRCC1 genetic polymorphism Arg399Gln with esophageal cancer risk in the Chinese population

“…Our analysis also demonstrated that the XRCC1 Gln399 allele elevated risk of ESCC in Chinese, which is inconsistent with the study of Dai et al (2009). The different results may be due to the studies performed in the last 3 years and included in our meta-analysis.…”

Effects of JWA, XRCC1 and BRCA1 mRNA expression on molecular staging for personalized therapy in patients with advanced esophageal squamous cell carcinoma

“…The DNA repair protein XRCC1 interacted with enzymatic components which include PARP-1, DNA polymerase β, APE1, PNK, PCNA and DNA ligase III in BER pathway [14-19]. Single nucleotide polymorphisms (SNPs) of XRCC1 gene acted as a risk factor might be a valuable genetic marker for chemotherapy in various cancers containing esophageal cancer [20-22]. Our group has demonstrated the possibility of JWA participating in tailored therapy of tumor for its novel function as regulator of XRCC1.…”

CYP1A1 Genetic Polymorphisms and Risk for Esophageal Cancer: a Case-control Study in Central China

“…Recently, many investigators have reported association between CYP1A1 polymorphisms and cancers (Dai et al, 2009;Atinkaya et al, 2012;Lopez-Cima et al, 2012;Sergentanis et al, 2012;Ding et al, 2013), especially for two main functional polymorphic sites of CYP1A1 gene (MspI and Ile/Val) and cancer susceptibility. Previous studies (Kawajiri et al, 1990;Nakachi et al, 1991;Hayashi et al, 1992;Xu et al, 1996) have suggested that variant allele of CYP1A1 MspI polymorphisms is associated with malignancies, particularly lung cancer.…”