XRCC3 Thr241Met Gene Polymorphism and Risk of Colorectal Cancer in Kashmir: a Case Control Study

Nissar, Saniya; Sameer, Aga Syed; Lone, Tufail Ahmad; Chowdri, Nissar A.; Rasool, Roohi

doi:10.7314/apjcp.2014.15.22.9621

Cited by 12 publications

(11 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several recent studies have investigated the association between XRCC3 Thr241Met polymorphism and different types of cancers, but the results are contradictory. Some studies have found that XRCC3 Thr241Met polymorphism is associated with a high risk of cancer, such as glioma, hepatocellular carcinoma, colorectal cancer, breast cancer, head and neck cancer and gastric cancer (Duan et al, 2013;Luo et al, 2013;Kayani et al, 2014;Nissar et al, 2014;Qureshi et al, 2014). Duan and colleagues investigated the role of XRCC3 Thr241Met polymorphism in hepatocellular carcinoma, and reported that the Met/Met and Thr/Met+Met/Met genotypes were significantly associated with hepatocellular carcinoma in a Chinese population (Duan et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Kayani and colleagues investigated the role of XRCC3 Thr241Met gene polymorphism in head and neck cancer and reported that XRCC3 Thr241Met polymorphism was an independent risk factor for head and neck cancer . Nissar and colleagues conducted a study with 120 colorectal cancer and 150 healthy subjects in an Indian population, and reported that Thr/Met and Met/Met Genotypes of XRCC3 Thr241Met were corrected with colorectal cancer (Nissar et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population

Guo¹,

Hc²,

Shi³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Osteosarcoma is one of the most common bone malignancies in adolescents, and hereditary factors may influence its susceptibility. We assessed the association between XRCC3 Thr241Met polymorphism and susceptibility to osteosarcoma in a Chinese population. Between May 2012 and May 2014, a total of 136 osteosarcoma patients and 136 healthy control subjects were included in our study. The XRCC3 Thr241Met polymorphism was analyzed using a polymerase chain reaction restriction fragment length polymorphism assay. By multiple logistic regression analysis, individuals carrying the Met/Met genotype of XRCC3 Thr241Met were at significantly increased risk of osteosarcoma when compared with the Thr/Thr (OR = 2.50, 95%CI = 1.13-5.66). The Thr/Met+Met/Met genotype of XRCC3 Thr241Met was furthermore found to be correlated with an elevated increased risk of osteosarcoma when compared with the Thr/Thr genotype (OR = 1.71, 95%CI = 1.03-2.87), and Met/Met genotype of XRCC3 Thr241Met was associated with an increased risk of osteosarcoma compared to the Thr/ Thr (OR = 3.50, 95%CI = 1. 51-8.79). In conclusion, our study firstly reports 16485 XRCC3 Thr241Met polymorphism and osteosarcoma risk ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 16484-16490 (2015) that XRCC3 Thr241Met gene polymorphism is associated with an elavated risk of osteosarcoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population

Guo¹,

Hc²,

Shi³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…Thus far, little has been known about the potential causes needing further investigation. In addition, some of the studies conducted in Asian countries had a very small sample size and did not have adequate power to detect the possible risk for XRCC3 Thr241Met polymorphism, and the observed significant ORs in these studies may be false associations (Wang et al, 2010;Nissar et al, 2014). Also, most of the studies have shown that the polymorphism of XRCC3 Thr241Met to contribute to the development of CRC across Caucasian ethnicity countries in many previous individual studies (Improta et al, 2008;Krupa et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Association between the XRCC3 Thr241Met Polymorphism and Risk of Colorectal Cancer: a Meta Analysis of 5,193 Cases and 6,645 Controls

Namazi¹,

Abedinzadeh²,

Nourbaksh³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…However, there was no relationship of rs25489, rs25487 and rs13181 with PTC. The mutations in XRCC genes may cause decrease or loss of DNA repair capacity and confer the variation in development of many malignant tumors, and previously, some studies have reported that XRCC1 and XRCC3 gene polymorphisms may modify the risk for some types of cancer, such as gastric cancer [13], glioma [14], breast cancer [15] and colorectal cancer [16]. But to date, less study focused on the association between XRCC gene polymorphisms and PTC risk, especially for Chinese population, and these published literatures could not concluded a consistent result.…”

Section: Discussionmentioning

confidence: 99%

Interaction Between XRCC1 Gene Polymorphisms and Obesity on Susceptibility to Papillary Thyroid Cancer in Chinese Han Population

Zhu¹,

Pan²,

Li³

2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: To investigate the association of several single nucleotide polymorphisms (SNPs) within XRCC gene and additional gene- environment interaction with papillary thyroid cancer (PTC) risk. Methods: Testing for Hardy-Weinberg equilibrium in controls was conducted using SNPstats (online software: http://bioinfo.iconcologia.net/SNPstats). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among 5 SNPs within XRCC gene and obesity. Results: Logistic regression analysis showed that the C allele of rs861539 and T allele of rs1799782 were associated with increased PTC risk Adjusted ORs (95%CI) were 1.65 (1.23-2.12) and 1.61 (1.20-2.04). However There was no relation of rs25489 Rs25487 and rs13181 with PTC. The cross-validation consistency and the testing accuracy for each of the models were determined by GMDR analysis. One two-locus model (rs1799782 and obesity) had a testing accuracy of 62.11% Which was significant at the p < 0.01 level. The D’ value between rs1799782 and rs13181 within ERCC1 gene was more than 0.75 (0.825). So haplotype analysis was just conducted for rs1799782 and rs13181 using the SHEsis online haplotype analysis software. In all samples The haplotype C- A was observed most frequently in two groups With 49.46% and 55.79% in the PTC patients and controls Respectively. The results also indicated that haplotype T- C was significantly associated with increased PTC risk. Conclusion: The C allele of rs861539 and T allele of rs1799782 Interaction between rs1799782 and obesity and haplotype T- C were all associated with increased PTC risk.

show abstract

XRCC3 Thr241Met Gene Polymorphism and Risk of Colorectal Cancer in Kashmir: a Case Control Study

Cited by 12 publications

References 31 publications

Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population

Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population

Association between the XRCC3 Thr241Met Polymorphism and Risk of Colorectal Cancer: a Meta Analysis of 5,193 Cases and 6,645 Controls

Interaction Between XRCC1 Gene Polymorphisms and Obesity on Susceptibility to Papillary Thyroid Cancer in Chinese Han Population

Contact Info

Product

Resources

About