XXI. An Essay on the use of Nitrate of Silver, in the cure of Inflammations, Wounds, and Ulcers.

Higginbottom, John

doi:10.1097/00000441-183108170-00021

Cited by 2 publications

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“…Historically, silver nitrate has been used extensively for a variety of conditions, and the first description of its clinical application was described in 1829 by Higginbottom for the treatment of ulcers and granulations 1 . Fortunately, the use of silver nitrate as a cure for involuntary spermatorrhoea, described by Thompson in the first volume of the Lancet in 1852, is not one of the current indications (Fig.…”

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Silver nitrate: histological effects of cautery on epithelial surfaces with varying contact times

et al. 2003

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Silver nitrate is used extensively in rhinological practice for the treatment of recurrent epistaxis. There are currently no recommendations in the literature regarding the optimum application time of this chemical for effective treatment. We assessed the histological effects of silver nitrate on mucosal tissue at varying contact times and made recommendations based on our findings. Silver nitrate was applied at predetermined contact times to tonsillar mucosa, immediately before tonsillectomy in subjects undergoing routine surgery. The cauterized areas were subsequently analysed histologically. The depth of tissue penetration by the silver nitrate was measured. The means for 5, 10 and 20 s were 0.44, 0.30 and 0.38, respectively, P = 0.3. Overall, there was no deeper penetration of the tissues with contact times over 5 s. We conclude that it is not necessary to apply silver nitrate for greater than 5 s to achieve maximal tissue penetration.

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Silver nitrate: histological effects of cautery on epithelial surfaces with varying contact times

et al. 2003

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“…Silver nitrate has been used in surgical practice for centuries. It was first described in 1829 by Higginbottom for the management of inflammatory wounds and ulcers 1 . Silver nitrate is an inorganic compound and when exposed to water, it ionises into free silver ions, which acts on tissues and blood vessels causing coagulation necrosis and thrombus formation 2 .…”

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The erroneous appearance of silver nitrate on computerised tomography imaging in patients with severe otitis externa; a case series

Javed

Hashmi

Qayyum

2022

Clinical Otolaryngology

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Silver nitrate has been used in surgical practice for centuries. It was first described in 1829 by Higginbottom for the management of inflammatory wounds and ulcers. 1 Silver nitrate is an inorganic compound and when exposed to water, it ionises into free silver ions, which acts on tissues and blood vessels causing coagulation necrosis and thrombus formation. 2 Its antiseptic action is now described as being primarily related to apoptosis leading to cell death. 2 Because of these antiseptic and wound healing properties, it is commonly used as a topical agent for cauterising bleeding points; especially over mucosal surfaces, burning granulations and even cauterising the non-healing ulcers for acceleration of the healing process. 3 Granulations in necrotizing otitis externa (OE) are very common and are considered to be one of the diagnostic criteria. 4 These lesions are often managed by applying silver nitrate especially after taking biopsies due to its dual effect. 5 Silver nitrate not only provides haemostasis but further inhibits fibroblast proliferation resulting in rapid resolution of the granulation tissues. 3

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XXI. An Essay on the use of Nitrate of Silver, in the cure of Inflammations, Wounds, and Ulcers.

Cited by 2 publications

References 0 publications

Silver nitrate: histological effects of cautery on epithelial surfaces with varying contact times

Silver nitrate: histological effects of cautery on epithelial surfaces with varying contact times

The erroneous appearance of silver nitrate on computerised tomography imaging in patients with severe otitis externa; a case series

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