Xylaropyrone, a new γ-pyrone from the endophytic fungus Xylaria feejeensis MU18

ChemInform Abstract: Secondary Metabolites from the Genus Xylaria and Their Bioactivities

“…Compounds 48 and 49 were isolated from the fungus Xylaria sp. Sordaricin (55) was isolated from the endophytic Xylaria sp. Sphaeropsidin C (50) and xylopimarane (51) were isolated from the fungus Xylaria sp.…”

“…Coloration B (139) was obtained from Xylaria intracolorata [49]. Xylaropyrone (159) was isolated from the endophytic Xylaria feejeensis MU 18 [55]. were reported from the endophytic fungus Xylaria sp.…”

“…Xylarenones A and B (9 and 10, resp. Sordaricin (55) displayed the best antifungal activity against C. albicans with an MIC value of 32 mg/ml, but it was much less active than amphotericin B (MIC 0.25 mg/ml) [19]. Phomenone (13) exhibited antifungal activity at a detection limit of 10.0 mg, comparable with the same amount of the standard nystatin [9].…”

Osteoclastogenesis Inhibitory Polyketides from the Sponge‐Associated Fungus Xylaria feejeensis

“…The compound displayed a moderate antiyeast activity against Saccharomyces cerevisiae ATCC 6275. [14] Four kinds of metabolites, namely nonenolide, [15] pestalotin 4'-O-methyl-β-mannopyranoside and polyketide derivatives, [16] integric acid [17] and coriloxine derivatives [18] were reported to have shown potential phytotoxic activity, [18] and inhibitory activities against Pythium ultimum, [15] α-glucosidase [16] and HIV-I integrase. [17] There has been no report of chemical investigation on X. feejeensis associated with marine organisms.…”

Mycoleptione, a new chromone derivative isolated from the endophytic fungus Mycoleptodiscus sp. MU41

“…As some of the biological activity of the plants used for medicinal purposes might be attributed to the microbes inhabiting the plants, particular attention has been paid to the endophytes, and consequently several novel compounds have been obtained. [3][4][5][6] During our preliminary screening to discover structurally novel secondary metabolites of endophytic fungi isolated from Thai medicinal plants, 7 an endophytic fungus, Mycoleptodiscus sp., was isolated from Tinospora crispa. T. crispa has been used as traditional medicine in rural society in Thailand in order to treat fever, cholera, snake bites, rheumatism and fever due to malaria.…”