1999
DOI: 10.1074/jbc.274.39.27914
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Y Receptor-mediated Induction of CD63 Transcripts, a Tetraspanin Determined To Be Necessary for Differentiation of the Intestinal Epithelial Cell Line, hBRIE 380i Cells

Abstract: Peptide YY (PYY) and neuropeptide Y (NPY) are peptides that coordinate intestinal activities in response to luminal and neuronal signals. In this study, using the rat hybrid small intestinal epithelial cell line, hBRIE 380i cells, we demonstrated that PYY-and NPY-induced rearrangement of actin filaments may be in part through a Y1␣ and/or a nonneuronal Y2 receptor, which were cloned from both the intestinal mucosa and the hBRIE 380i cells. A number of PYY/NPY-responsive genes were also identified by subtractiv… Show more

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Cited by 15 publications
(14 citation statements)
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“…PYY and NPY Reduce CD63 mRNA Expression in Pre-confluent Cells and Reduce Cell Adherence in a Time-and Dosedependent Fashion-PYY/NPY induce I-FABP and CD63 in post-confluent fully differentiated hBRIE 380i cells (31,32). The expression levels of CD63 affect those of I-FABP.…”
Section: Resultsmentioning
confidence: 99%
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“…PYY and NPY Reduce CD63 mRNA Expression in Pre-confluent Cells and Reduce Cell Adherence in a Time-and Dosedependent Fashion-PYY/NPY induce I-FABP and CD63 in post-confluent fully differentiated hBRIE 380i cells (31,32). The expression levels of CD63 affect those of I-FABP.…”
Section: Resultsmentioning
confidence: 99%
“…Antisense CD63 experiments utilized the plasmid construct described previously (32), which contained the full CD63 open reading frame inserted into the expression vector in the antisense orientation.…”
Section: Methodsmentioning
confidence: 99%
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