Y1R control of sciatic nerve blood flow in the Wistar Kyoto rat

This study used an anaesthetized rat model to directly observe changes in diameter of the vessels supplying the sciatic nerve in response to acetylcholine (10 M), a muscarinic receptor agonist, and atropine (10 M), a muscarinic receptor antagonist. Topical application of acetylcholine resulted in increases in vessel diameter (baseline: 22.0 ± 2.5 μm, acetylcholine: 28.8 ± 3.3 μm), while topical application of atropine resulted in a decrease in diameter (baseline: 26.6 ± 3.2 μm, atropine: 15.5 ± 3.6 μm) of the epineurial vessels. Mean arterial pressure was not affected by either acetylcholine (baseline: 103.8 ± 1.8 mm Hg, acetylcholine: 102.8 ± 3.2 mm Hg) or atropine (baseline: 104.0 ± 1.9 mm Hg, atropine: 105.2 ± 2.2 mm Hg). These data suggest that muscarinic-receptor-mediated responses can affect the diameter of the epineurial vessels at the sciatic nerve. In addition, muscarinic-receptor-mediated responses appear to contribute to baseline diameter of epineurial vessels at the sciatic nerve.

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Y1R control of sciatic nerve blood flow in the Wistar Kyoto rat

Cited by 4 publications

References 36 publications

The Microcirculation of Peripheral Nerves

The Microcirculation of Peripheral Nerves

Evidence of bidirectional flow in the sciatic vasa nervorum

The contribution of muscarinic-receptor-mediated responses to epineurial vascular diameter at the sciatic nerve

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