Yacon (Smallanthus sonchifolius) use as an antioxidant in diabetes

Ferraz, Ana Paula Costa Rodrigues; Garcia, Jéssica Leite; Costa, Marcela de Rezende; Almeida, Carol Cristina Vágula De; Gregolin, Cristina Schimitt; Alves, Pedro Henrique Rizzi; Hasimoto, Fabiana Kurokawa; Berchieri-Ronchi, Carolina Bragiola; Santos, Klinsmann Carolo dos; Corrêa, Camila Renata

doi:10.1016/b978-0-12-815972-9.00036-6

Cited by 4 publications

(8 citation statements)

References 49 publications

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“…DN is acknowledged as the main cause of the end-stage renal disease ( 28 ). The pathogenesis is indicated by mesangial proliferation in the nephron ( 4 ) and involves various pathways, including mitochondrial damage and ROS, and renal fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of yacon leaves extract (Smallanthus sonchifolius (Poepp.) H. Rob) through antifibrosis, anti-inflammatory, and antioxidant mechanisms toward diabetic nephropathy

Widowati¹,

Tjokropranoto²,

Onggowidjaja³

et al. 2023

Research in Pharmaceutical Sciences

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Background and purpose: Diabetic nephropathy (DN) is a chronic kidney failure, which may lead to fatality. Mesangial cell proliferation, renal inflammation, stress oxidative, and fibrosis are involved in DN progression. Yacon leaves ( Smallanthus sonchifolius (Poepp.) H. Rob.) contains large amounts of phenolic compounds and it has the ability to inhibit oxidative stress, inflammation, and fibrosis. Considering the potential of yacon leaves extract (YLE), it may be used for DN treatment. This research aimed to elucidate YLE’s potential as anti-DN through anti-inflammatory, antioxidant, and antifibrosis mechanisms. Experimental approach: Mesangial cells were induced by glucose 20 mM for 5 days and treated with YLE concentrations as much as 5, 10, and 50 µg/mL. TGF-β1, TNF-α, and MDA levels were measured using the ELISA method. SMAD2, SMAD3, SMAD4, and SMAD7 gene expressions were analyzed using the qRT-PCR method. Findings/Results: YLE at 5, 10, and 50 µg/mL could reduce the levels of TGF-β1, TNF-α, and MDA compared with the DN cells model. YLE could reduce gene expressions of SMAD2, SMAD3, and SMAD4 and increase SMAD7 expression. Conclusion and implications: YLE potentially mitigated diabetic nephropathy through antifibrosis, anti-inflammatory, and antioxidant capacities.

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Section: Discussionmentioning

confidence: 99%

Protective effect of yacon leaves extract (Smallanthus sonchifolius (Poepp.) H. Rob) through antifibrosis, anti-inflammatory, and antioxidant mechanisms toward diabetic nephropathy

Widowati¹,

Tjokropranoto²,

Onggowidjaja³

et al. 2023

Research in Pharmaceutical Sciences

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“…Average tuber weight fluctuates from 100 to 500 g, and rarely reaches more than 1 kg [77]. Yacon root tubers have great nutritional potential due to its sweet taste and lower energy content (619-937 kJ/kg of fresh matter) provided by its 70% water composition [78].…”

Section: Phytochemical Profile Of Smallanthus Sonchifolius Tuberous Rmentioning

confidence: 99%

“…S. sonchifolius roots are also rich in fructose, glucose, sucrose, amount of which fluctuates during the growing cycle, and harvest [77,78,80].…”

Section: Phytochemical Profile Of Smallanthus Sonchifolius Tuberous Rmentioning

confidence: 99%

“…Other important biologically active substances in the composition of yacon root tubers are phenolic compounds. The phenols group include chlorogenic acid, protocatechuic acid, p-coumaric acid, ferulic acid, and caffeic acid derivatives [77][78][79]. Phenolic acids have a high antioxidant potential result from the presence of an aromatic ring, a carboxyl group, and one or more hydroxyl and/or methoxyl groups in the molecule [83].…”

Section: Phytochemical Profile Of Smallanthus Sonchifolius Tuberous Rmentioning

confidence: 99%

“…Yacon leaves, next to the root tubers, also have a high potential, both in nutritional purposes and in medical practice. It can be consumed as a tea, also can be used as a material for raw and organic extracts [78].…”

Section: Phytochemical Profile Of Smallanthus Sonchifolius Leavesmentioning

confidence: 99%

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Red Wine and Yacon as a Source of Bioactive Compounds with Antidiabetic and Antioxidant Potential

Nagalievska¹,

Sabadashka²,

Sybirna³

2021

Alternative Medicine - Update

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Phytochemicals derived from different plants are promising therapeutic agents. Herbal compounds can be used under diseases, etiological causes of which are alterations of carbohydrate, protein, and lipid metabolisms, along with increased oxidative stress and chronic low-grade inflammation. Potential sources of biologically active substances may be grape wine, rich in phenolic compounds. Well-studied examples of polyphenols are phenolic acids, catechins, anthocyanins, and flavonoids, etc. Another source of biologically active compounds is yacon (Smallanthus sonchifolius Poepp. & Endl.). The aboveground part of yacon is rich in phenolic compounds and terpenes. Main biologically active substances from tuberous roots of yacon are fructooligosaccharides and phenolic compounds. The section will be devoted to the analysis of hypoglycemic and antioxidant effects, and molecular targets of the complex of biologically active substances derived from red wine and yacon.

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Physico-chemical and sensory characterization of sweet biscuits made with Yacon flour (Smallanthus sonchifolius)

et al. 2021

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Yacon (Smallanthus sonchifolius) use as an antioxidant in diabetes

Cited by 4 publications

References 49 publications

Protective effect of yacon leaves extract (Smallanthus sonchifolius (Poepp.) H. Rob) through antifibrosis, anti-inflammatory, and antioxidant mechanisms toward diabetic nephropathy

Protective effect of yacon leaves extract (Smallanthus sonchifolius (Poepp.) H. Rob) through antifibrosis, anti-inflammatory, and antioxidant mechanisms toward diabetic nephropathy

Red Wine and Yacon as a Source of Bioactive Compounds with Antidiabetic and Antioxidant Potential

Physico-chemical and sensory characterization of sweet biscuits made with Yacon flour (Smallanthus sonchifolius)

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