Yangkyuk-Sanhwa-Tang induces changes in serum cytokines and improves outcome in focal stroke patients

Aspects of gene polymorphisms in cerebral infarction: inflammatory cytokines

“…In clinical studies, Jeong et al [113] reported that serum IL-2 levels, but not IFN-g, decreased significantly in the patients with CI compared with controls. In contrast they also reported that a significant increase of TNFa [114], IL-4 [115], IL-6 [115] and immunoglobulin E (IgE) [116] serum levels was observed in the patients with CI (table 1). Recent studies have investigated the effect of Korean medicines on IL-4 and IL-10 production in humans from lipopolysaccharides (LPS) or phytohaemagglutininstimulated peripheral blood mononuclear cells (PBMCs) of CI patients.…”

A review of the neuro- and systemic inflammatory responses in post concussion symptoms: Introduction of the “post-inflammatory brain syndrome” PIBS

“…Reducing inflammation has also been shown to reduce dizziness in some conditions. For example Yangkyuk-SanhwaTang, a Chinese herbal formulation, has been shown to reduce both dizziness and levels of pro-inflammatory cytokines TNF-a and IL-6 in Soyangin cerebral infarction patients (Jeong et al, 2002). Kao et al (2014) found that levels of SIRT1, a downregulator of the NF-jB pro-inflammatory pathway, were reduced in patients with chronic dizziness and that vestibular exercise therapy both increased SIRT1 expression and improved dizziness.…”

Physiome and Sasang Constitutional Medicine

“…It was shown that interleukin (IL)-4 and IL-6 in blood decreased and assisted the recovery of damaged neuronal cells [25,26]. Furthermore, studies related to the regulation of cytokine secretion have been performed [27][28][29][30]. Although these studies have not been productive because of the technological limitations of standard molecular biology, SCM experiments using existing clinical data of Western medicine combined with gene information may reveal relationships worthy of further study.…”