YAP in development and disease: Navigating the regulatory landscape from retina to brain

Zhao, Yaqin; Sun, Bin; Fu, Xuefei; Zuo, Zhuan; Qin, Huan; Yao, Kai

doi:10.1016/j.biopha.2024.116703

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.116703

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YAP in development and disease: Navigating the regulatory landscape from retina to brain

Yaqin Zhao,

Bin Sun,

Xuefei Fu

et al.

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2024

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Cited by 3 publications

References 249 publications

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Anesthetic effects on electrophysiological responses across the visual pathway

Zhang,

Xu,

Liu

et al. 2024

Sci Rep

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Anesthetics are widely used in electrophysiological tests to assess retinal and visual system functions to avoid experimental errors caused by movement and stress in experimental animals. To determine the most suitable anesthetic for visual electrophysiological tests, excluding ketamine and chloral hydrate due to regulatory and side effect concerns, this study investigated the effects of ethyl carbamate (EC), avertin (AR), and pentobarbital sodium (PS) on visual signal conduction in the retina and primary visual cortex. Assessments included flash electroretinogram (FERG), pattern electroretinogram (PERG), pattern visual evoked potentials (PVEP), and flash visual evoked potentials (FVEP), FERG and FVEP were used to evaluate the responses of the retina and visual cortex to flash stimuli, respectively, while PERG and PVEP assessed responses to pattern stimuli. The research showed that AR demonstrates the least disruption to the visual signal pathway, as evidenced by consistently high characteristic peaks in the AR group across various tests. In contrast, mice given EC exhibited the lowest peak values in both FERG and FVEP, while subjects anesthetized with PS showed suppressed oscillatory potentials and PERG responses. Notably, substantial PVEP characteristic peaks were observed only in mice anesthetized with AR. Consequently, among the three anesthetics tested, AR is the most suitable for visual electrophysiological studies.

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Anesthetic effects on electrophysiological responses across the visual pathway

Zhang,

Xu,

Liu

et al. 2024

Sci Rep

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From bench to bedside: cutting-edge applications of base editing and prime editing in precision medicine

Xu,

Zhang,

Qin

et al. 2024

J Transl Med

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CRISPR-based gene editing technology theoretically allows for precise manipulation of any genetic target within living cells, achieving the desired sequence modifications. This revolutionary advancement has fundamentally transformed the field of biomedicine, offering immense clinical potential for treating and correcting genetic disorders. In the treatment of most genetic diseases, precise genome editing that avoids the generation of mixed editing byproducts is considered the ideal approach. This article reviews the current progress of base editors and prime editors, elaborating on specific examples of their applications in the therapeutic field, and highlights opportunities for improvement. Furthermore, we discuss the specific performance of these technologies in terms of safety and efficacy in clinical applications, and analyze the latest advancements and potential directions that could influence the future development of genome editing technologies. Our goal is to outline the clinical relevance of this rapidly evolving scientific field and preview a roadmap for successful DNA base editing therapies for the treatment of hereditary or idiopathic diseases.

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Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease

Xu,

Fu,

Qin

et al. 2024

Front. Cell. Neurosci.

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DNA methylation plays a crucial role in development, aging, degeneration of various tissues and dedifferentiated cells. This review explores the multifaceted impact of DNA methylation on the retina and brain during development and pathological processes. First, we investigate the role of DNA methylation in retinal development, and then focus on retinal diseases, detailing the changes in DNA methylation patterns in diseases such as diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma. Since the retina is considered an extension of the brain, its unique structure allows it to exhibit similar immune response mechanisms to the brain. We further extend our exploration from the retina to the brain, examining the role of DNA methylation in brain development and its associated diseases, such as Alzheimer’s disease (AD) and Huntington’s disease (HD) to better understand the mechanistic links between retinal and brain diseases, and explore the possibility of communication between the visual system and the central nervous system (CNS) from an epigenetic perspective. Additionally, we discuss neurodevelopmental brain diseases, including schizophrenia (SZ), autism spectrum disorder (ASD), and intellectual disability (ID), focus on how DNA methylation affects neuronal development, synaptic plasticity, and cognitive function, providing insights into the molecular mechanisms underlying neurodevelopmental disorders.

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YAP in development and disease: Navigating the regulatory landscape from retina to brain

Cited by 3 publications

References 249 publications

Anesthetic effects on electrophysiological responses across the visual pathway

Anesthetic effects on electrophysiological responses across the visual pathway

From bench to bedside: cutting-edge applications of base editing and prime editing in precision medicine

Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease

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