YAP1-TEAD1 mediates the perineural invasion of prostate cancer cells induced by cancer-associated fibroblasts

Shen, Tianyu; Li, Yang; Wang, Dekun; Su, Yu; Li, Gang; Shang, Zhiqun; Niu, Yuanjie; Tan, Xiaoyue

doi:10.1016/j.bbadis.2022.166540

Cited by 13 publications

(6 citation statements)

References 42 publications

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“…In a study conducted by Shen et al, YAP1 expression level was upregulated when co-culturing CAFs and PDAC cells. Furthermore, this study confirmed that CAFs can enhance perineural invasion in PDAC by activating the YAP1/TEAD1/NGF pathway [ 140 ]. CAFs also exert an influence on CRC.…”

Section: The Cross-talk Between the Nervous System And Tme In Gi Tumo...supporting

confidence: 67%

The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention

Lyu,

Xie,

Chen

et al. 2023

Oncogene

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Gastrointestinal (GI) cancer is a formidable malignancy with significant morbidity and mortality rates. Recent studies have shed light on the complex interplay between the nervous system and the GI system, influencing various aspects of GI tumorigenesis, such as the malignance of cancer cells, the conformation of tumor microenvironment (TME), and the resistance to chemotherapies. The discussion in this review first focused on exploring the intricate details of the biological function of the nervous system in the development of the GI tract and the progression of tumors within it. Meanwhile, the cancer cell-originated feedback regulation on the nervous system is revealed to play a crucial role in the growth and development of nerve cells within tumor tissues. This interaction is vital for understanding the complex relationship between the nervous system and GI oncogenesis. Additionally, the study identified various components within the TME that possess a significant influence on the occurrence and progression of GI cancer, including microbiota, immune cells, and fibroblasts. Moreover, we highlighted the transformation relationship between non-neuronal cells and neuronal cells during GI cancer progression, inspiring the development of strategies for nervous system-guided anti-tumor drugs. By further elucidating the deep mechanism of various neuroregulatory signals and neuronal intervention, we underlined the potential of these targeted drugs translating into effective therapies for GI cancer treatment. In summary, this review provides an overview of the mechanisms of neuromodulation and explores potential therapeutic opportunities, providing insights into the understanding and management of GI cancers.

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Section: The Cross-talk Between the Nervous System And Tme In Gi Tumo...supporting

confidence: 67%

The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention

Lyu,

Xie,

Chen

et al. 2023

Oncogene

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“…In prostate cancer, the YAP1/TEAD complex mediates the occurrence of PNI by activating the transcription of the nerve growth factor NGF ( 14 ). In pancreatic cancer, the overexpression of YAP1 may promote invasiveness, epithelial-mesenchymal transition (EMT), and resistance to gemcitabine.…”

Section: Discussionmentioning

confidence: 99%

“…In gastric cancer, acetylcholine activates the Yes-associated protein (YAP) via the M3 muscarinic receptor (M3R) signaling pathway, thereby regulating the Wnt/β-Catenin signaling pathway and promoting cancer cell proliferation ( 13 ). YAP1 has the ability to bind with TEAD and recruit nerves by activating the transcription of the neural growth factor NGF, and research indicates a significant correlation between the occurrence of PNI in prostate cancer and the expression level of YAP1 in tumor tissues ( 14 ). In mouse models of gastric cancer, surgical or pharmacological denervation (by cutting or injecting botulinum toxin A) significantly slowed tumor progression and inhibited Wnt signaling and tumor stem cell expansion ( 15 ).…”

Section: Neural Promotion Of Tumor Cell Proliferationmentioning

confidence: 99%

Periampullary cancer and neurological interactions: current understanding and future research directions

Wang,

Liu,

Tian

et al. 2024

Front. Oncol.

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Periampullary cancer is a malignant tumor occurring around the ampullary region of the liver and pancreas, encompassing a variety of tissue types and sharing numerous biological characteristics, including interactions with the nervous system. The nervous system plays a crucial role in regulating organ development, maintaining physiological equilibrium, and ensuring life process plasticity, a role that is equally pivotal in oncology. Investigations into nerve-tumor interactions have unveiled their key part in controlling cancer progression, inhibiting anti-tumor immune responses, facilitating invasion and metastasis, and triggering neuropathic pain. Despite many mechanisms by which nerve fibers contribute to cancer advancement still being incompletely understood, the growing emphasis on the significance of nerves within the tumor microenvironment in recent years has set the stage for the development of groundbreaking therapies. This includes combining current neuroactive medications with established therapeutic protocols. This review centers on the mechanisms of Periampullary cancer’s interactions with nerves, the influence of various types of nerve innervation on cancer evolution, and outlines the horizons for ongoing and forthcoming research.

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“…Some studies have demonstrated the Hippo-TEAD pathway modulates cell proliferation and function in both nonmalignant mature differentiated and malignant cells 35 . A preliminary investigation has revealed that TEAD1 binds to the NGF promotor and that YAP1/TEAD1 increases its transcription, resulting in improved cell invasion 36 . However, only few studies have investigated these ceRNAs.…”

Section: Discussionmentioning

confidence: 99%

The Analysis of ceRNA Networks and Tumor Microenvironment in Endometrial Cancer

Huang,

Yang,

et al. 2024

J. Cancer

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Background: Endometrial carcinoma is a life-threatening and aggressive tumor that affects women worldwide. ceRNAs and carcinoma-infiltrating immunocytes can be associated with tumor formation and progression. Therefore, investigating the unique mechanisms underlying endometrial carcinoma is crucial. Methods: Prognostic nomograms were constructed based on the differentially expressed genes between normal and tumor tissues. Twenty types of tumor immune infiltrating cells in uterine corpus endometrial carcinoma (UCEC) were examined using CIBERSORT. To identify the potential signaling pathways, the associations among essential ceRNA network genes and important immunocytes were investigated using the co-expression assay. Results: Differential analysis identified 3636 mRNAs, 249 miRNAs, and 252 lncRNAs unique to UCEC. The ceRNA network was constructed using the interplays between 19 lncRNA-miRNA pairs and 434 miRNA-mRNA pairs. Furthermore, CIBERSORT and ceRNA integration analysis revealed that immune cells, including dendritic cells and natural killer cells, and associated ceRNAs such as LRP8, HDGF, PPARGC1B, and TEAD1 can appropriately predict prognosis. A receiver operating characteristic curve was constructed to predict patient outcomes. Conclusions: Using a nomogram, we predicted the outcomes of patients with UCEC Furthermore, we revealed its significance in improving clinical management.

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YAP1-TEAD1 mediates the perineural invasion of prostate cancer cells induced by cancer-associated fibroblasts

Cited by 13 publications

References 42 publications

The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention

The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention

Periampullary cancer and neurological interactions: current understanding and future research directions

The Analysis of ceRNA Networks and Tumor Microenvironment in Endometrial Cancer

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