Yazumycin, a New Antibiotic Produced by Streptomyces Lavendulae

Akasaki, Katsuyuki; Abe, Hiroshi; Seino, Akio; Shirato, Shiroh

doi:10.7164/antibiotics.21.98

Cited by 16 publications

(8 citation statements)

References 3 publications

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“…We have, therefore, examined in some detail the action of one of these agents, monazomycin. Monazomycin is an antibiotic of proposed empirical formula C6 2 H,, 9 0 2 0 N produced by a Streptomyces (Akasaki et al, 1963). It contains numerous hydroxyl groups, one sugar residue, and one amino group which gives it a single positive charge over the pH range of our experiments (Mitscher et al, 1967).…”

Section: Introductionmentioning

confidence: 93%

Voltage-Dependent Conductance Induced in Thin Lipid Membranes by Monazomycin

Muller

Finkelstein

1972

The Journal of General Physiology

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When present in micromolar amounts on one side of phospholipid bilayer membranes, monazomycin (a positively charged, polyene-like antibiotic) induces dramatic voltage-dependent conductance effects. Voltage clamp records are very similar in shape to those obtained from the potassium conductance system of the squid axon. The steady-state conductance is proportional to the 5th power of the monazomycin concentration and increases exponentially with positive voltage (monazomycin side positive); there is an e-fold change in conductance per 4-6 my. The major current-carrying ions are univalent cations. For a lipid having no net charge, steady-state conductance increases linearly with KC1 (or NaCl) concentration and is unaffected by Ca + + or Mg++. The current-voltage characteristic which is normally monotonic in symmetrical salt solutions is converted by a salt gradient to one with a negative slope-conductance region, although the conductance-voltage characteristic is unaffected. A membrane treated with both monazomycin and the polyene antibiotic nystatin (which alone creates anion-selective channels) displays bistability in the presence of a salt gradient. Thus monazomycin and nystatin channels can exist in parallel. We believe that many monazomycin monomers (within the membrane) cooperate to form a multimolecular conductance channel; the voltage control of conductance arises from the electric field driving monazomycin molecules at the membrane surface into the membrane and thus affecting the number of channels that are formed.

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Section: Introductionmentioning

confidence: 93%

Voltage-Dependent Conductance Induced in Thin Lipid Membranes by Monazomycin

Muller

Finkelstein

1972

The Journal of General Physiology

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“…The original culture of S. lavendulae was isolated from soil by Waksman and Curtis in 1916 [36]. Since Waksman and Woodruff isolated streptothricin from it in 1942 [37], numerous reports explored the secondary metabolites and their further functions of S. lavendulae, including antibacterial, antifungal, antioxidant, cytotoxic, and antiviral activities [38][39][40][41][42][43]. For decades, the research on S. lavendulae that has focused on its fermentation broth.…”

Section: Discussionmentioning

confidence: 99%

Identification of Rhizospheric Actinomycete Streptomyces lavendulae SPS-33 and the Inhibitory Effect of its Volatile Organic Compounds against Ceratocystis fimbriata in Postharvest Sweet Potato (Ipomoea batatas (L.) Lam.)

Cai

et al. 2020

Microorganisms

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Black spot disease, which is caused by the pathogenic fungal Ceratocystis fimbriata, seriously affects the production of sweet potato and its quality during postharvest storage. In this study, the preliminary identification of the rhizosphere actinomycete strain SPS-33, and its antifungal activity of volatiles in vitro and in vivo was investigated. Based on morphological identification and phylogenetic analysis of the 16S rRNA gene sequence, strain SPS-33 was identified as Streptomyces lavendulae. Volatile organic compounds (VOCs) emitted by SPS-33 inhibited mycelial growth and sporulation of C. fimbriata in vitro and also induced a series of observable hyphae morphological changes. In an in vivo pathogenicity assay, exposure to SPS-33 significantly decreased the lesion diameter and water loss rate in sweet potato tuberous roots (TRs) inoculated with C. fimbriata. It increased the antioxidant enzymes’ activities of peroxidase, catalase, and superoxide dismutase as well as decreased malondialdehyde and increased total soluble sugar. In the VOC profile of SPS-33 detected by a headspace solid-phase micro extraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS), heptadecane, tetradecane, and 3-methyl-1-butanol were the most abundant compounds. 2-Methyl-1-butanol, 3-methyl-1-butanol, pyridine, and phenylethyl alcohol showed strong antifungal effects against C. fimbriata. These findings suggest that VOCs from S. lavendulae SPS-33 have the potential for pathogen C. fimbriata control in sweet potato postharvest storage by fumigant action.

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“…Marginolactones consist of a macrolactone backbone and a side chain containing a guanidyl-or amino group (25). The marginolactones desertomycin A and monazomycin are produced by Streptomyces macronensis and Streptomyces mashuensis, respectively (26,27).…”

Section: Azalomycin F and Other Marginolactones Specifically Induce F...mentioning

confidence: 99%

Ubiquitous bacterial polyketides induce cross-kingdom microbial interactions

Krespach

Stroe

Netzker

et al. 2022

Preprint

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Although the interaction of prokaryotic and eukaryotic microorganisms is critical for the functioning of ecosystems, knowledge of the processes driving microbial interactions within communities is in its infancy. We previously reported that the soil bacterium Streptomyces iranensis specifically triggers the production of natural products in the fungus Aspergillus nidulans. Here, we discovered that arginine-derived polyketides serve as the bacterial signals for this induction. Arginine-derived polyketide-producing bacteria occur world wide. These producer bacteria and the fungi that decode and respond to this signal can be co-isolated from the same soil sample. Arginine-derived polyketides impact surrounding microorganisms both directly as well as indirectly, by inducing the production of natural products in fungi that further influence the composition of microbial consortia.One-Sentence SummaryUbiquitous bacterial polyketides are universal components of the chemical network for microbial communication

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Yazumycin, a New Antibiotic Produced by Streptomyces Lavendulae

Cited by 16 publications

References 3 publications

Voltage-Dependent Conductance Induced in Thin Lipid Membranes by Monazomycin

Voltage-Dependent Conductance Induced in Thin Lipid Membranes by Monazomycin

Identification of Rhizospheric Actinomycete Streptomyces lavendulae SPS-33 and the Inhibitory Effect of its Volatile Organic Compounds against Ceratocystis fimbriata in Postharvest Sweet Potato (Ipomoea batatas (L.) Lam.)

Ubiquitous bacterial polyketides induce cross-kingdom microbial interactions

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