Yellow fever in the diagnostics laboratory

Domingo, Christina; Charrel, Rémi N.; Schmidt‐Chanasit, Jonas; Zeller, H.; Reusken, Chantal

doi:10.1038/s41426-018-0128-8

Cited by 59 publications

(63 citation statements)

References 81 publications

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“…Laboratory diagnosis of Yellow fever is generally accomplished by molecular biology studies such as reverse transcriptionpolymerase chain reaction (RT-PCR), immuno histochemistry/histopathological analysis and serological tests (32,33).…”

Section: Diagnosis Of Yellow Fevermentioning

confidence: 99%

“…Despite the availability of an effective vaccine, the re-emergence of Yellow fever is directly linked with its continuous dissemination in several countries. Brazil, Angola, Democratic Republic of Congo, and Nigeria accounted for thousands of documented cases between 2016 and 2018 (4), which can be interpreted as a probable indicator of what will occur if no action is taken. Therefore, this review highlights the epidemiological features and the current outbreak of Yellow fever in Nigeria.…”

Section: Introductionmentioning

confidence: 99%

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Review Article: Yellow fever in Nigeria: A review of the current situation

Adogo¹,

Ogoh²

2019

Af J Clin Exp Micro

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Several African countries including Nigeria have been battling with public health challenges for decades. Nigeria is currently facing several public health emergencies including cholera, circulating vaccine-derived poliovirus infection, cerebrospinal meningitis, monkey pox, measles, Lassa fever, and Yellow fever outbreaks in some states, as well as a humanitarian crisis in the northeast region of the country. Sporadic outbreaks of Yellow fever have been occurring in the country since September 2017 involving all thirty six states of the Federation, resulting in about 90 deaths (case fatality rate of 2.2%) and 31 deaths among confirmed cases (case fatality rate of 19.0%). Although, there is currently no specific treatment for Yellow fever, vaccination with the Yellow fever vaccine provides life-long protection, and is the most important means of preventing the disease. Despite the availability of an effective vaccine, the re-emergence of Yellow fever is directly correlated with its continuous dissemination in several countries to date. Timely detection of Yellow fever and rapid response through emergency vaccination campaigns are essential for controlling outbreaks. Vector surveillance and control are important components of reducing transmission in epidemic situations. This review attempts to provide update information on the current situation of Yellow fever in Nigeria with highlights on the history, pathogenesis and diagnosis of the disease.

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Section: Diagnosis Of Yellow Fevermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Review Article: Yellow fever in Nigeria: A review of the current situation

Adogo¹,

Ogoh²

2019

Af J Clin Exp Micro

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“…well as the urban mosquito species Aedes aegypti [1,2]. In Africa, the savannah transmission cycle connects the sylvatic and urban cycles of both humans and monkeys, which are infected by Aedes mosquitoes [3].…”

mentioning

confidence: 99%

Yellow fever epizootics in non-human primates, Southeast and Northeast Brazil (2017 and 2018)

et al. 2020

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Background: Yellow fever (YF) is a severe, infectious, but non-communicable arboviral hemorrhagic disease. In the last decades, yellow fever virus (YFV) infections have been prevalent in endemic areas in Brazil, affecting human and non-human primate (NHP) populations. Monitoring of NHP infection started in 1999, and reports of epizootic diseases are considered important indicators of viral transmission, particularly in relation to the sylvatic cycle. This study presents the monitoring of YFV by real-time RT-PCR and the epidemiological findings related to the deaths of NHPs in the southeastern states and in the northeastern state of Bahia, during the outbreak of YF in Brazil during 2017 and 2018. Methods: A total of 4198 samples from 2099 NHPs from southeastern and northeastern Brazilian states were analyzed by real-time reverse transcription polymerase chain reaction (rtRT-PCR). Results: A total of 4198 samples from 2099 NHPs from southeastern and northeastern Brazilian states were collected between 2017 and 2018. The samples were subjected to molecular diagnostics for YFV detection using realtime reverse transcription polymerase chain reaction (rtRT-PCR) techniques. Epizootics were coincident with human YF cases. Furthermore, our results showed that the YF frequency was higher among marmosets (Callithrix sp.) than in previous reports. Viremia in species of the genus Alouatta and Callithrix differed greatly. Discussion: Our results indicate a need for further investigation of the role of Callithrix spp. in the transmission cycles of YFV in Brazil. In particular, YFV transmission was observed in a region where viral circulation has not been recorded for decades and thus vaccination has not been previously recommended. Conclusions: This highlights the need to straighten epizootic surveillance and evaluate the extent of vaccination programmes in Brazil in previously considered "YFV-free" areas of the country.

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“…These outbreaks ended in 2017 with 7334 suspected cases and 393 deaths (Kraemer et al 2017). In 2016, another outbreak occurred in Uganda, and since then, several sporadic yellow fever cases have been reported in Chad, Ghana, the Republic of Congo, Guinea and Nigeria (Domingo et al 2018).…”

Section: Yellow Fevermentioning

confidence: 99%