Yersinia enterocolitica infection—An unrecognized cause of acute and chronic neurological disease? A 10-year follow-up study on 458 hospitalized patients

Saebø, A; Nyland, H.; Lassen, J

doi:10.1016/0306-9877(93)90249-p

Cited by 7 publications

(1 citation statement)

References 20 publications

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“…Pigs infected with the wild-type strain developed clear histological changes in the lungs as catarrhal pneumonia, lymphohistiocytic nodules in the liver, splenitis in the spleen, catarrhal enteritis in the intestines and meningoencephalitis in the brain. Meningitis and encephalitis were observed by Saebo et al (1993) in Y. enterocoliticainfected patients suffering from an acute or chronic neurological illness; the patients also displayed a positive anti-Yersinia antibody response. Our previous work indicated the dissemination of Y. enterocolitica serotype O:3 in lung macrophages (Nikolova et al, 1997).…”

Section: Discussionmentioning

confidence: 98%

Experimental pig yersiniosis to assess attenuation ofYersinia enterocoliticaO:8 mutant strains

Najdenski

Golkocheva

Kussovski

et al. 2006

FEMS Immunology &Amp; Medical Microbiology

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An experimental oral pig model was used to assess the pathogenic and immunogenic potential of Yersinia enterocolitica serotype O:8 wild-type strain 8081-L2 and its lipopolysaccharide (LPS) mutant derivatives: a spontaneous rough mutant 8081-R2, strain 8081-DwzzGB expressing O-antigen with uncontrolled chain lengths, and strain 8081-wbcEGB expressing semirough LPS with only one O-unit. Microbiological and immunological parameters of the infected pigs were followed from day 7 to 60 postinfection. The wild-type and all LPS mutant strains persisted in the lymphoid tissue of tonsils and small intestines, causing asymptomatic infection without any pathological changes. Although the pig is known as a reservoir of Yersiniae, a precise analysis of pathogenic and immunogenic parameters based on different in vitro tests (hematological response, killing ability of leukocytes and blood sera, antibody response, hydrogen peroxide production by macrophages, classical and alternative pathways of complement activation), revealed significant attenuation in the pathogenicity of the LPS mutant strains but not the loss of immunogenic potential. In comparison with the other strains, strain 8081-DwzzGB demonstrated more continuous leucocytosis with monocytosis, higher invasive potential, significant activation of hydrogen peroxide production by macrophages and an effective immunoglobulin G immune response accompanied by relevant histological immunomorphological rearrangements.

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Section: Discussionmentioning

confidence: 98%

Experimental pig yersiniosis to assess attenuation ofYersinia enterocoliticaO:8 mutant strains

Najdenski

Golkocheva

Kussovski

et al. 2006

FEMS Immunology &Amp; Medical Microbiology

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Spondylodiscitis of the lumbar spine in a non-immunocompromised host caused by Yersinia enterocolitica O:9

Ellenrieder

Zautner

Podbielski

et al. 2009

Arch Orthop Trauma Surg

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Here presented is an extremely rare case of a spinal osteomyelitis (L5-S1) with epidural empyema in a non-immunocompromised 62-year-old man caused by Yersinia enterocolitica O:9. The infection occurred acutely and required immediate surgical treatment. Y. enterocolitica was cultured from the empyema fluid, wound swabs of the intervertebral disc L5-S1 and stool cultures. Following the surgical decompression and antibiotic treatment, the patient recovered completely, without neurological deficits. A review of the literature revealed only sparse cases of spondylodiscitis due to other Y. enterocolitica serogroups. To our knowledge, we report here the first case of a spondylodiscitis of the lumbar spine caused by Y. enterocolitica serovar O:9 in a non-immunocompromised patient.

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Antibodies against homologous microbial caseinolytic proteases P characterise primary biliary cirrhosis

Bogdanos

Baum

Sharma

et al. 2002

Journal of Hepatology

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Yersinia enterocolitica infection—An unrecognized cause of acute and chronic neurological disease? A 10-year follow-up study on 458 hospitalized patients

Cited by 7 publications

References 20 publications

Experimental pig yersiniosis to assess attenuation ofYersinia enterocoliticaO:8 mutant strains

Experimental pig yersiniosis to assess attenuation ofYersinia enterocoliticaO:8 mutant strains

Spondylodiscitis of the lumbar spine in a non-immunocompromised host caused by Yersinia enterocolitica O:9

Antibodies against homologous microbial caseinolytic proteases P characterise primary biliary cirrhosis

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