YgiV promoter mutations cause resistance to cystobactamids and reduced virulence factor expression in Escherichia coli

Risch, Timo; Kolling, Dominik; Mostert, Dietrich; Seedorf, Tim; Heimann, Dominik; Kohnhäuser, Daniel; Deschner, Felix; Fries, Franziska; Solga, Danny; Hilgers, Jil-Sophie; Dastbaz, Jan; Mancini, Stefano; Hirsch, Anna K. H.; Brönstrup, Mark; Kirschning, Andreas; Sieber, Stephan A.; Herrmann, Jennifer; Müller, Rolf

doi:10.1038/s44259-024-00050-7

npj Antimicrob Resist

2024

DOI: 10.1038/s44259-024-00050-7

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YgiV promoter mutations cause resistance to cystobactamids and reduced virulence factor expression in Escherichia coli

Timo Risch,

Dominik Kolling,

Dietrich Mostert

et al.

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Harnessing Gram‐negative bacteria for novel anti‐Gram‐negative antibiotics

Birkelbach,

Seyfert,

Walesch

et al. 2024

Microbial Biotechnology

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Natural products have proven themselves as a valuable resource for antibiotics. However, in view of increasing antimicrobial resistance, there is an urgent need for new, structurally diverse agents that have the potential to overcome resistance and treat Gram‐negative pathogens in particular. Historically, the search for new antibiotics was strongly focussed on the very successful Actinobacteria. On the other hand, other producer strains have been under‐sampled and their potential for the production of bioactive natural products has been underestimated. In this mini‐review, we highlight prominent examples of novel anti‐Gram negative natural products produced by Gram‐negative bacteria that are currently in lead optimisation or preclinical development. Furthermore, we will provide insights into the considerations and strategies behind the discovery of these agents and their putative applications.

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Harnessing Gram‐negative bacteria for novel anti‐Gram‐negative antibiotics

Birkelbach,

Seyfert,

Walesch

et al. 2024

Microbial Biotechnology

View full text Add to dashboard Cite

show abstract

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YgiV promoter mutations cause resistance to cystobactamids and reduced virulence factor expression in Escherichia coli

Cited by 1 publication

References 33 publications

Harnessing Gram‐negative bacteria for novel anti‐Gram‐negative antibiotics

Harnessing Gram‐negative bacteria for novel anti‐Gram‐negative antibiotics

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