“…ERCP brush cytology is still probably the most commonly used ERCP sampling technique [10], as it is easy and convenient to perform, but its sensitivity for malignant bile duct strictures ranges from 30 % to 69 % ± far less than ideal, although a few studies have reported higher sensitivities, particularly for detecting cholangiocarcinoma [11 ± 21]. Several studies suggest that ERCP-FNA is no better than other cytological techniques [22,23], although there have been some encouraging reports of higher sensitivity rates for cancer detection using forceps biopsy at ERCP [13,24,25]. It is reasonably evident that using more than one sampling method will improve the diagnostic yield of ERCP tissue collection ± as shown, for example, in an elegant prospective study evaluating the use of so-called ªtriple-tissueº sampling with brush cytology, FNA, and forceps biopsy [26].…”