Yiqi Yangyin and Huatan Quyu granule can improve skeletal muscle energy metabolism in a type 2 diabetic rat model by promoting the AMPK/SIRT/PGC-1α signalling pathway

Wei, Huang; Liu, Jinna; Zhao, Jing; Wang, Bangzhong; Liu, Biyuan; Xie, Ming

doi:10.1016/j.jtcms.2018.03.004

Cited by 5 publications

(3 citation statements)

References 45 publications

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“…Creatine kinase, an intracellular enzyme, is chiefly found in the cytoplasm and mitochondria of the myocardium, skeletal muscle, and brain (Eleazu et al, 2021; Huang et al, 2018). The enzyme catalyzes the addition of phosphate group to creatine to form creatine phosphate which serves as a source of energy in the muscle during muscle contraction (Aboonabi et al, 2014; Huang et al, 2018). We did not find any change in creatine kinase activity, in the skeletal muscle of the disease with respect to the control.…”

Section: Discussionmentioning

confidence: 99%

Tert‐butylhydroquinone abrogates fructose‐induced insulin resistance in rats via mitigation of oxidant stress, NFkB‐mediated inflammation in the liver but not the skeletal muscle of high fructose drinking rats

Eleazu¹,

Obeten²,

Ozor³

et al. 2022

Journal of Food Biochemistry

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The effect of 21% fructose drinking water (FDW) (w/v) on some parameters of metabolic syndrome, hepatic, and skeletal muscular histology of rats was studied using standard techniques. Twenty male albino rats were divided into four groups of 5 rats each in this in vivo study. Group I received distilled water, group 2 received FDW, group 3 received FDW and metformin (300 mg/kg body weight daily, orally), group 4 received FDW and 1% tert‐butylhydroquinone feed. FDW changed the serum leptin, triacylglycerol, very low‐density lipoprotein, and C‐reactive protein levels of the rats, inducing hypertriglyceridemia, oxidative stress, and inflammation in their liver (but not the skeletal muscle) and insulin resistance which were modulated with metformin and tBHQ as corroborated by liver and muscle histology. The study reveals the potentials of metformin and tBHQ in mitigating hepatic and skeletal muscular morphological changes arising from exposure to high fructose drinks. Practical applications There has been an increase in the global consumption of fructose (either as a sweetner in beverages or soft and carbonated drinks) in the last few decades and this has been positively correlated with the global increase in metabolic complications. Regular intake of fructose contributes to the pathogenesis of lipid disorders, oxidant stress, and chronic inflammation, which are linked with the metabolic syndrome components (MetS) (obesity, insulin resistance, and cardiovascular diseases) as well as increased morbidity and mortality. Given that the approaches that have been applied to treat the MetS have not been able to totally arrest it, currenty study which showed that tBHQ abrogated fructose‐induced insulin resistance, dyslipidemia, hepatic, and skeletal muscular pathology in the rats places tBHQ in the spotlight as a nutraceutical that could be of relevance in mitigating high dietary fructose‐induced hepatic and skeletal muscular pathology.

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Section: Discussionmentioning

confidence: 99%

Tert‐butylhydroquinone abrogates fructose‐induced insulin resistance in rats via mitigation of oxidant stress, NFkB‐mediated inflammation in the liver but not the skeletal muscle of high fructose drinking rats

Eleazu¹,

Obeten²,

Ozor³

et al. 2022

Journal of Food Biochemistry

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“…CK is an intracellular enzyme that is mainly present in the cytoplasm and mitochondria of the skeletal muscle, myocardium, and brain. (Akuru & Tebekeme, 2017;Huang et al, 2018). The enzyme is directly related to cellular energy metabolism, muscle contraction, and ATP regeneration (Aboonabi et al, 2014;Huang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…(Akuru & Tebekeme, 2017;Huang et al, 2018). The enzyme is directly related to cellular energy metabolism, muscle contraction, and ATP regeneration (Aboonabi et al, 2014;Huang et al, 2018). In fact, during muscular injury, CK is released from the cellular cytosol of the muscle cells into the systemic circulation and as such, it is the most widely used enzyme for the evaluation of muscular injury (Aboonabi et al, 2014;Akuru & Tebekeme, 2017;Huang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Effect of bee bread on some biochemical parameters and skeletal muscle histology of high‐fat diet‐induced obese Sprague‐Dawley rats

et al. 2021

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Obesity is a disorder of body weight regulatory systems that is characterized by an accumulation of excess body fat due to hyperplasia and hypertrophy of adipocytes (Eleazu et al., 2019; Ferrier, 2014). Several factors have been implicated in the etiology of obesity including genetic and environmental factors, stress, disequilibrium in energy intake and expenditure, increased energy from gut/intestinal

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Studies on the mechanism of energy metabolism via AMPK/PGC‐1α signaling pathway induced by compatibility of Ligusticum chuanxiong Hort and Gastrodia

Yang

Lin

et al. 2022

Phytotherapy Research

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AMP‐activated protein kinase (AMPK) regulates overall energy consumption and energy intake through cytokines. Ligusticum striatum DC (CX) combined with Gastrodia elata Blume (TM) has been used for migraine treatment for millennia. When used alone in clinical practice, CX causes symptoms of thirst, irritability, and yellow urine and has influenced the levels of cytokines such as AMP that activate the AMPK pathway of energy metabolism. However, relationships between this compatibility prescription, integral biological energy metabolism, and the AMPK pathway remain unclear. Studies were performed by treating normal rats with physiological saline, CX extract, CX coupled TM extract, and TM extracts separately for 4 weeks. Food intake, water intake, urine output, stool output, and body weight were monitored once a week by the metabolic cage method. Values of FBG, BUN, TP, TC and TG in blood samples were detected approaching the whole blood automatic detector from 1 to 4 weeks. Na+‐K+‐ATPase, Ca2+‐Mg2+‐ATPase, cAMP, and cGMP activity were determined by the enzyme‐linked immunosorbent assay (ELISA); the biological samples that were obtained at 1, 2, 3, and 4 weeks after drug administration were tested by GC‐TOF‐MS. Then real‐time PCR and Western Blot were applied to detect changes in expression of some substances involved in energy metabolism. The results demonstrated that administering CX alone increased energy input, mobility, and respiratory exchange ratio, accelerated energy consumption, and caused inflammatory infiltration in the liver. CX coupled with TM led to lower energy metabolism and liver damage in comparison with CX used alone. Moreover, CX‐treated rats harbored higher levels of differential metabolites (including pyrophosphate, oxaloacetic acid, and galactinol). Glycerophospholipid metabolism and the citrate cycle are closely related to the differential metabolites above. In addition, CX‐induced unbalanced energy metabolism depends on cAMP activation mediated by the AMPK/PGC‐1α pathway in rats. Our findings suggest that CX‐induced energy metabolism imbalance was corrected after coupling with TM by mediating the AMPK/PGC‐1α pathway.

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Yiqi Yangyin and Huatan Quyu granule can improve skeletal muscle energy metabolism in a type 2 diabetic rat model by promoting the AMPK/SIRT/PGC-1α signalling pathway

Cited by 5 publications

References 45 publications

Tert‐butylhydroquinone abrogates fructose‐induced insulin resistance in rats via mitigation of oxidant stress, NFkB‐mediated inflammation in the liver but not the skeletal muscle of high fructose drinking rats

Tert‐butylhydroquinone abrogates fructose‐induced insulin resistance in rats via mitigation of oxidant stress, NFkB‐mediated inflammation in the liver but not the skeletal muscle of high fructose drinking rats

Effect of bee bread on some biochemical parameters and skeletal muscle histology of high‐fat diet‐induced obese Sprague‐Dawley rats

Studies on the mechanism of energy metabolism via AMPK/PGC‐1α signaling pathway induced by compatibility of Ligusticum chuanxiong Hort and Gastrodia

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