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Калашникова, В. А.; Dzhikidze, E. K.; Stasilevich, Z K; Chikobava, M. G.

doi:10.1023/a:1021528122942

Cited by 19 publications

(5 citation statements)

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“…While Campylobacter occurs in many wildlife species, clinical signs of gastrointestinal illness or adverse health effects have rarely been observed. Two noctule bats (Nyctalus noctula; Hazeleger et al, 2018), a dozen rhesus monkeys (Macaca mulatta; Kalashnikova et al, 2002), and several vervet monkeys (Chlorocebus pygerythrus; Ngotho et al, 2006) infected with Campylobacter spp. presented with signs of acute gastrointestinal disease.…”

Section: Life Traits and Species Interactions With Conspecifics And S...mentioning

confidence: 99%

Campylobacter in aquatic and terrestrial mammals is driven by life traits: A systematic review and meta-analysis

et al. 2023

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IntroductionCampylobacter spp. infections are responsible for significant diarrheal disease burden across the globe, with prevalence thought to be increasing. Although wild avian species have been studied as reservoirs of Campylobacter spp., our understanding of the role of wild mammalian species in disease transmission and persistence is limited. Host factors influencing infection dynamics in wild mammals have been neglected, particularly life traits, and the role of these factors in zoonotic spillover risk is largely unknown.MethodsHere, we conducted a systematic literature review, identifying mammalian species that had been tested for Campylobacter spp. infections (molecular and culture based). We used logistic regression to evaluate the relationship between the detection of Campylobacter spp. in feces and host life traits (urban association, trophic level, and sociality).ResultsOur analysis suggest that C. jejuni transmission is associated with urban living and trophic level. The probability of carriage was highest in urban-associated species (p = 0.02793) and the most informative model included trophic level. In contrast, C. coli carriage appears to be strongly influenced by sociality (p = 0.0113) with trophic level still being important. Detection of Campylobacter organisms at the genus level, however, was only associated with trophic level (p = 0.0156), highlighting the importance of this trait in exposure dynamics across host and Campylobacter pathogen systems.DiscussionWhile many challenges remain in the detection and characterization of Camploybacter spp., these results suggest that host life traits may have important influence on pathogen exposure and transmission dynamics, providing a useful starting point for more directed surveillance approaches.

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Section: Life Traits and Species Interactions With Conspecifics And S...mentioning

confidence: 99%

Campylobacter in aquatic and terrestrial mammals is driven by life traits: A systematic review and meta-analysis

et al. 2023

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“…A number of studies 20,28,32,38,47,55,57,59 have explored CID in captive macaques, but, to our knowledge, none have specifically characterized and compared the fecal microbiomes of healthy adult and diarrheic animals or of corralled and free-ranging animals by using 16S rRNA gene sequences. The 2 field sites of the Caribbean Primate Research Center offer a unique opportunity to compare macaques in a semiwild state with those in a more traditional large, outdoor-corral facility.…”

Section: Discussionmentioning

confidence: 99%

“…47,55,71 However, identification of Campylobacter in as many as 42% of healthy subjects brings into question whether its presence is as a primary or an opportunistic pathogen. 32,38,59 Campylobacter spp. in diarrheic subjects overall had a much higher level of virulent gene expression than did Campylobacter spp.…”

Section: Discussionmentioning

confidence: 99%

“…The specific changes we found in CID macaques were similar to those previously reported in macaques and other species. 3,23,26,32,38,55 Therefore, the influence of different collection times on the fecal microbiota probably was minimal. A final limitation of our study is that frozen samples were softened in a biosafety cabinet for approximately 2 h before processing.…”

Section: Discussionmentioning

confidence: 99%

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Fecal Bacterial Microbiota of Healthy Free-Ranging, Healthy Corralled, and Chronic Diarrheic Corralled Rhesus Macaques (Macaca mulatta)

Compo¹,

Mieles-Rodriguez

Gómez

2021

comp med

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A clinical challenge to nearly every primate facility in North America is chronic idiopathic diarrhea (CID), the pathogenesis of which has yet to be fully elucidated. However, wild macaques appear resistant to CID, a trend that we observed in the free-ranging population of the Caribbean Primate Research Center. The gastrointestinal microbiota has been shown to have a significant role in the pathogenesis of disease and in maintaining normal health and development of the gut. In humans, chronic diarrhea is associated with alteration of the gut microbiota, which has lower bacterial diversity than does the microbiota of healthy humans. The current study was designed to describe and compare the fecal bacterial microbiota of healthy corralled, CID corralled, and healthy, free-ranging macaques. Fresh fecal samples were collected from healthy corralled (HC; n = 30) and CID (n = 27) rhesus macaques and from healthy macaques from our free-ranging colony (HF; n = 43). We excluded macaques that had received antibiotics during the preceding 60 d (90 d for healthy animals). Bacterial DNA was extracted, and the V4 region of the 16S rRNA gene was sequenced and compared with known databases. The relative abundance of Proteobacteria was higher in CID animals than HC animals, but otherwise few differences were found between these 2 groups. HF macaques were differentially enriched with Christensenellaceae and Helicobacter, which are highly associated with a ‘healthy’ gut in humans, as compared to corralled animals, whereas CID animals were enriched with Proteobacteria, which are associated with dysbiosis in other species. These results indicate that environment has a greater influence than health status on the gut microbiota. Furthermore, the current data provided targets for future studies on potential clinical interventions, such as probiotics and fecal transplants.

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“…From an open colony with near 100% prevalence may not be feasible. 23 In addition, agreement between CROs and pharmaceutical industry processes and procedures must be in place to ensure negative status to avoid repeat treatment of animals for clinical disease and exposure of carriers to non-carriers that may experience severe weight loss and dehydration while on study. Adding to the complexity of managing recurrent diarrhea is the reported high prevalence of antimicrobial resistance in zoonotic bacteria including Shigella and Campylobacter [24][25][26] as well as consideration given to the limitations of laboratory testing, sensitivity and specificity.…”

Section: Usefulness Of Fecal Diagnostic Testing and Histopathology (M...mentioning

confidence: 99%

Non-Human Primate Husbandry and Impact on Non-Human Primates Health: Outcomes From an IQ DruSafe/3RS Industrial Benchmark Survey

et al. 2022

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The presence of health issues (diarrhea, poor body condition) in non-human primates can impact animal welfare, confound toxicity study data, and lead to animal exclusion from studies. A working group cosponsored by DruSafe and 3Rs Translational and Predictive Sciences Leadership Groups of the IQ Consortium conducted a survey to benchmark quarantine, pre-study screening, husbandry, and veterinary care practices and their impact on NHP health. Nineteen companies participated in the survey providing separate responses for studies conducted in-house and at Contract Research Organizations from 3 regions (North America (NA), Europe and Asia) for an aggregate of 33 responses. A majority of responding companies conducted studies at North America CROs (39%) or in-house (36%) using primarily Chinese (33%) or Cambodian (27%) and to a lesser extent Vietnam (18%) or Mauritian (15%) origin NHPs. Forty-Five percent of responses had pre-study health issues (fecal abnormalities, etc.) on ≥ 1 studies with the highest incidence observed in Vietnam origin NHPs (80%). The survey suggested variable pre-screening and quarantine practices across facilities. Husbandry practices including behavioral assessments, environmental enrichment and consistent diets were associated with a lower incidence of health issues. The survey also benchmarked approaches used to diagnose and manage abnormal feces in NHPs and has provided strategies to minimize impact on NHP health. The survey highlighted opportunities for harmonizing screening criteria across industry and for improving tracking and sharing of health screening results, leading to further refinement of NHP veterinary care practices, higher quality studies, and reduced NHP use.

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Cited by 19 publications

References 0 publications

Campylobacter in aquatic and terrestrial mammals is driven by life traits: A systematic review and meta-analysis

Campylobacter in aquatic and terrestrial mammals is driven by life traits: A systematic review and meta-analysis

Fecal Bacterial Microbiota of Healthy Free-Ranging, Healthy Corralled, and Chronic Diarrheic Corralled Rhesus Macaques (Macaca mulatta)

Non-Human Primate Husbandry and Impact on Non-Human Primates Health: Outcomes From an IQ DruSafe/3RS Industrial Benchmark Survey

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