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Isachenko, A. S.; Isachkova, L. M.; Бузолева, Л. С.; Пустовалов, Е. В.; Somov, G. P.

doi:10.1023/a:1002856003897

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“…A generalization of the results of studies obtained during model experiments made it possible to establish a complex of ultrastructural changes in the FESLF causative agent under different ecological conditions similar to those in a warm-blooded organism and the environment. It was concluded that these changes in bacteria of periodic and soil cultures that ensure their functional usefulness should be considered as an adaptive response of bacterial populations to changing living conditions, which demonstrates the universal, morphological mechanism of their adaptation [30,31]. A long stay of Y. pseudotuberculosis in the soil is provided by phenotypic changes at the ultrastructure level and is expressed in the formation of a capsule and microcapsule, general cover, mucus, intercellular contacts, cytoplasmic outgrowths (prostakes), and accumulation of reserve substances [25,27,32].…”

Section: Morphological Aspects Of the Y Pseudotuberculosis Adaptation To Various Living Conditionsmentioning

confidence: 99%

Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of Yersinia pseudotuberculosis Infection in Russia

Сомова¹,

Antonenko

Тимченко³

et al. 2020

Pathogens

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Pseudotuberculosis in humans until the 1950s was found in different countries of the world as a rare sporadic disease that occurred in the form of acute appendicitis and mesenteric lymphadenitis. In Russia and Japan, the Yersinia pseudotuberculosis (Y. pseudotuberculosis) infection often causes outbreaks of the disease with serious systemic inflammatory symptoms, and this variant of the disease has been known since 1959 as Far Eastern Scarlet-like Fever (FESLF). Russian researchers have proven that the FESLF pathogen is associated with a concrete clonal line of Y. pseudotuberculosis, characterized by a specific plasmid profile (pVM82, pYV 48 MDa), sequence (2ST) and yadA gene allele (1st allele). This review summarized the most important achievements in the study of FESLF since its discovery in the Far East. It has been established that the FESLF causative agent is characterized by a unique phenomenon of psychrophilicity, which consists of its ability to reproduce in the environment with its biologically low and variable temperature (4–12 °C), at which the pathogen multiplies and accumulates while maintaining or increasing its virulence, which ensures the emergence and development of the epidemic process. The key genetic and biochemical mechanisms of Y. pseudotuberculosis adaptation to changing environmental conditions were characterized, and the morphological manifestations of the adaptive variability of these bacteria in different conditions of their habitat were revealed. The main features of the pathogenesis and morphogenesis of FESLF, including those associated with the Y. pseudotuberculosis toxigenicity, were presented. The pathogenetic value of the plasmid PVM82, found only in the FESLF pathogen, was shown.

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Section: Morphological Aspects Of the Y Pseudotuberculosis Adaptation To Various Living Conditionsmentioning

confidence: 99%