Abstract--Patients with asthma will experience a decrease in pulmonary function due to airway obstruction. Yoga Pranayama is a practice of meditation, self-hypnosis with positive suggestions and breathing exercise for patients with asthma that can cause optimal ventilation. This study was to explain the effect of Yoga Pranayama to pulmonary function improvement of patients with asthma in Puskesmas IV Denpasar Selatan. The study was using a quasiexperimental design with two group pre-post test design. The population was patient with asthma in Puskesmas IV Denpasar Selatan with a total sample of 12 patients, consisted of 6 patients for intervention group dan six patients for the control group. The independent variable was Yoga Pranayama. The dependent variables were Peak Expiratory Flow Rate (PEF) and Oxygen Saturation (SaO2). Instruments were peak flow meter and pulse oximetry. Results showed that there was a significant difference in PEF (p=0.00), but there was no significant effect on the value of SaO2 (p=0.10). Yoga Pranayama can increase tidal volume. As a result the value of PEF increased. Future study may use spirometry and blood gas analyze for specific measuring the PEF and SaO2.