Yohimbine Ameliorates Temporomandibular Joint Chondrocyte Inflammation with Suppression of NF-κB Pathway

Ou, Farong; Huang, Yihuan; Sun, Jiadong; Su, Kai; Zeng, Ruifeng; Tang, Dongxiao; Liao, Guiqing

doi:10.1007/s10753-020-01310-0

Cited by 19 publications

(16 citation statements)

References 28 publications

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“…NF-κB signaling can be induced by periostin, a matricellular protein, then the MMPs and inflammatory cytokines can be upregulated NF-κB signaling activation to accelerate the OA pathogenesis [ 72 ]. Genistein played a protective role in condylar cartilage of OA by downregulating expression of NF-κB in rats [ 73 ]; while inflammation of TMJ chondrocytes can be ameliorated by Yohimbine through suppression of NF-κB signaling pathway [ 74 ]. Celecoxib may protect excessive mechanical stress-induced TMJ OA partially through inhibition of NF-κB signaling and suppression of MMP production [ 75 ].…”

Section: Molecular Signaling During Tmj Oa Developmentmentioning

confidence: 99%

Molecular signaling in temporomandibular joint osteoarthritis

et al. 2022

Journal of Orthopaedic Translation

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Section: Molecular Signaling During Tmj Oa Developmentmentioning

confidence: 99%

Molecular signaling in temporomandibular joint osteoarthritis

et al. 2022

Journal of Orthopaedic Translation

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“…Abnormal dental occlusion is one of the potential causes of TMJOA, which includes severe malocclusion and skeletal jaw asymmetry. Thus, the TMJOA models can be built by disordered occlusion, which is the TMJ-specific model-building approach, including orthodontic tooth movement ( Wang Q. Y. et al, 2012 ; Zhang et al, 2013 ), unilateral anterior crossbite ( Wang Y. L. et al, 2014 ; Zhang et al, 2016 ; Liu J. et al, 2020 ), unilateral bite-raise ( Long et al, 2019 ; Ou et al, 2021 ), mandibular movement restriction ( Teramoto et al, 2003 ; Li et al, 2013 ), mandibular advancement ( Yang et al, 2020 ; Li Y. et al, 2021 ), and mandibular lateral deviation ( Zhao et al, 2010 ; Zou et al, 2022 ). Injury to the TMJ can be caused by indirect force to the mandible, which may lead to local pain, dislocation, or fracture, even TMJOA.…”

Section: Classification Of Animal Models In Temporomandibular Joint O...mentioning

confidence: 99%

“…Currently, mechanical loading models are mainly applied to study the mechanism of pathological changes in TMJOA ( Jiao et al, 2009 ; Jiao et al, 2011 ; Ma et al, 2020 ; Ou et al, 2021 ), probably because this kind of model directly mimics the disease process in TMJOA patients caused by disordered occlusion. The pathogenic mechanism of TMJOA in mechanical loading models has been widely discussed.…”

Section: Classification Of Animal Models In Temporomandibular Joint O...mentioning

confidence: 99%

Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection

Zhao

Zhou

et al. 2022

Front. Physiol.

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Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease that can cause severe pain and dysfunction. It has a serious impact on the quality of lives of patients. Since mechanism underlying the pathogenesis of TMJOA is not fully understood, the development of effective tools for early diagnosis and disease-modifying therapies has been hindered. Animal models play a key role in understanding the pathological process of diseases and evaluating new therapeutic interventions. Although some similarities in disease processes between animals and humans are known, no one animal model is sufficient for studying all characteristics of TMJOA, as each model has different translatability to human clinical conditions. For the past 4 decades, TMJOA animal models have been studied by numerous researchers and can be broadly divided into induced, naturally occurring, and genetically modified models. The induced models can be divided into invasive models (intra-articular injection and surgical induction) or non-invasive models (mechanical loading, high-fat diet, and sleep deprivation). Different types of animal models simulate different pathological expressions of TMJOA and have their unique characteristics. Currently, mice, rats, and rabbits are commonly used in the study of TMJOA. This review sought to provide a general description of current experimental models of TMJOA and assist researchers in selecting the most appropriate models for different kinds of research.

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“…Ou et al. [ 11 ] reported anti-inflammatory properties of yohimbine that suppress the NF-κB pathway. Yohimbine reduced the IL-1β or noradrenaline-induced IL-6 upregulation and ameliorated cartilage destruction in condylar processes by suppressing the NF-κB pathway in vitro and in vivo .…”

Section: Introductionmentioning

confidence: 99%

A literature perspective on the pharmacological applications of yohimbine

et al. 2022

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Introduction: Phytochemicals have garnered much attention because they are useful in managing several human diseases. Yohimbine is one such phytochemical with significant pharmacological potential and could be exploited for research by medicinal chemists. It is an indole alkaloid obtained from various natural/synthetic sources. Aims and Results: The research on yohimbine started early, and its use as a stimulant and aphrodisiac by humans has been reported for a long time. The pharmacological activity of yohimbine is mediated by the combined action of the central and peripheral nervous systems. It selectively blocks the pre and postsynaptic α 2 -adrenergic receptors and has a moderate affinity for α 1 and α 2 subtypes. Yohimbine also binds to other behaviourally relevant monoaminergic receptors in the following order: α-2 NE > 5HT-1A>, 5HT-1B > 1-D > D3 > D2 receptors. Conclusion: The current review highlights some significant findings that contribute to developing yohimbine-based drugs. It also highlights the therapeutic potential of yohimbine against selected human diseases. However, further research is recommended on the pharmacokinetics, molecular mechanisms, and drug safety requirements using well-designed randomized clinical trials to produce yohimbine as a pharmaceutical agent for human use. Key Messages Yohimbine is a natural indole alkaloid with significant pharmacological potential. Humans have used it as a stimulant and aphrodisiac from a relatively early time. It blocks the pre- and postsynaptic α2-adrenergic receptors that could be exploited for managing erectile dysfunction, myocardial dysfunction, inflammatory disorders, and cancer.

show abstract

Yohimbine Ameliorates Temporomandibular Joint Chondrocyte Inflammation with Suppression of NF-κB Pathway

Cited by 19 publications

References 28 publications

Molecular signaling in temporomandibular joint osteoarthritis

Molecular signaling in temporomandibular joint osteoarthritis

Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection

A literature perspective on the pharmacological applications of yohimbine

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